Search Results - "Khan, Arif A."

Hepatitis E virus genotype 1f outbreak in Bangladesh, 2018 by Baki, Abdullah A., Haque, Warda, Giti, Susane, Khan, Arif A., Rahman, Mohammad M., Jubaida, Nishat, Rahman, Mustafizur

“…Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic…”
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MicroRNA-17∼92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections by Khan, Arif A., Penny, Laura A., Yuzefpolskiy, Yevgeniy, Sarkar, Surojit, Kalia, Vandana

“…The precise microRNAs and their target cellular processes involved in generation of durable T-cell immunity remain undefined. Here we show a dynamic regulation…”
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CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8+ TEM and CD8+ TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease by Srivastava, Ruchi, Khan, Arif A, Chilukuri, Sravya, Syed, Sabrina A, Tran, Tien T, Furness, Julie, Bahraoui, Elmostafa, BenMohamed, Lbachir

“…Herpes simplex virus 1 (HSV-1) establishes latency within the sensory neurons of the trigeminal ganglia (TG). HSV-specific memory CD8+ T cells play a critical…”
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CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8 + T EM and CD8 + T RM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease by Srivastava, Ruchi, Khan, Arif A, Chilukuri, Sravya, Syed, Sabrina A, Tran, Tien T, Furness, Julie, Bahraoui, Elmostafa, BenMohamed, Lbachir

“…Herpes simplex virus 1 (HSV-1) establishes latency within the sensory neurons of the trigeminal ganglia (TG). HSV-specific memory CD8 T cells play a critical…”
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CXCL17 Chemokine-Dependent Mobilization of CXCR8 + CD8 + Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes by Srivastava, Ruchi, Hernández-Ruiz, Marcela, Khan, Arif A, Fouladi, Mona A, Kim, Grace J, Ly, Vincent T, Yamada, Taikun, Lam, Cynthia, Sarain, Sheilouise A B, Boldbaatar, Undariya, Zlotnik, Albert, Bahraoui, Elmostafa, BenMohamed, Lbachir

“…Circulating conventional memory CD8 T cells (i.e., the CD8 effector memory T [T ] cell and CD8 central memory T [T ] cell subsets) and the noncirculating CD8…”
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Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107 + CD8 + T Cells That Infiltrate the Corneas and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge by Khan, Arif A, Srivastava, Ruchi, Vahed, Hawa, Roy, Soumyabrata, Walia, Sager S, Kim, Grace J, Fouladi, Mona A, Yamada, Taikun, Ly, Vincent T, Lam, Cynthia, Lou, Anthony, Nguyen, Vivianna, Boldbaatar, Undariya, Geertsema, Roger, Fraser, Nigel W, BenMohamed, Lbachir

“…Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea, causing potentially blinding herpetic disease. A clinical herpes vaccine…”
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A Herpes Simplex Virus Type 1 Human Asymptomatic CD8+ T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a "Humanized" HLA Transgenic Rabbit Model by Srivastava, Ruchi, Khan, Arif A, Huang, Jiawei, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…A clinical vaccine that protects from ocular herpes simplex virus type 1 (HSV-1) infection and disease still is lacking. In the present study, preclinical…”
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Bolstering the Number and Function of HSV-1-Specific CD8 + Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease by Khan, Arif A, Srivastava, Ruchi, Chentoufi, Aziz A, Kritzer, Elizabeth, Chilukuri, Sravya, Garg, Sumit, Yu, David C, Vahed, Hawa, Huang, Lei, Syed, Sabrina A, Furness, Julie N, Tran, Tien T, Anthony, Nesburn B, McLaren, Christine E, Sidney, John, Sette, Alessandro, Noelle, Randolph J, BenMohamed, Lbachir

“…HSV type 1 (HSV-1) is a prevalent human pathogen that infects >3.72 billion individuals worldwide and can cause potentially blinding recurrent corneal herpetic…”
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The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits by Srivastava, Ruchi, Dervillez, Xavier, Khan, Arif A, Chentoufi, Aziz A, Chilukuri, Sravya, Shukr, Nora, Fazli, Yasmin, Ong, Nicolas N, Afifi, Rasha E, Osorio, Nelson, Geertsema, Roger, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…Persistent pathogens, such as herpes simplex virus 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and destroyed by the…”
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Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy by Nalbandian, Angèle, Khan, Arif A., Srivastava, Ruchi, Llewellyn, Katrina J., Tan, Baichang, Shukr, Nora, Fazli, Yasmin, Kimonis, Virginia E., BenMohamed, Lbachir

“…Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response…”
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Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation by BenMohamed, Lbachir, Osorio, Nelson, Srivastava, Ruchi, Khan, Arif A., Simpson, Jennifer L., Wechsler, Steven L.

“…Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection…”
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HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8+ T cells from seropositive asymptomatic individuals and protect humanized HLA-A02:01 transgenic mice against ocular herpes by Srivastava, Ruchi, Khan, Arif A, Spencer, Doran, Vahed, Hawa, Lopes, Patricia P, Thai, Nhi Thi Uyen, Wang, Christine, Pham, Thanh T, Huang, Jiawei, Scarfone, Vanessa M, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…The HSV type 1 tegument virion phosphoprotein (VP) 11/12 (VP11/12) is a major Ag targeted by CD8(+) T cells from HSV-seropositive individuals. However, whether…”
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Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells by Khan, Arif A, Srivastava, Ruchi, Chentoufi, Aziz A, Geertsema, Roger, Thai, Nhi Thi Uyen, Dasgupta, Gargi, Osorio, Nelson, Kalantari, Mina, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…Most blinding ocular herpetic disease is due to reactivation of herpes simplex virus 1 (HSV-1) from latency rather than to primary acute infection. No herpes…”
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Asymptomatic HLA-A02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes by Dervillez, Xavier, Qureshi, Huma, Chentoufi, Aziz A, Khan, Arif A, Kritzer, Elizabeth, Yu, David C, Diaz, Oscar R, Gottimukkala, Chetan, Kalantari, Mina, Villacres, Maria C, Scarfone, Vanessa M, McKinney, Denise M, Sidney, John, Sette, Alessandro, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…Evidence from C57BL/6 mice suggests that CD8(+) T cells, specific to the immunodominant HSV-1 glycoprotein B (gB) H-2(b)-restricted epitope (gB498-505),…”
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Phenotypic and functional characterization of herpes simplex virus glycoprotein B epitope-specific effector and memory CD8+ T cells from symptomatic and asymptomatic individuals with ocular herpes by Khan, Arif A, Srivastava, Ruchi, Spencer, Doran, Garg, Sumit, Fremgen, Daniel, Vahed, Hawa, Lopes, Patricia P, Pham, Thanh T, Hewett, Charlie, Kuang, Jasmine, Ong, Nicolas, Huang, Lei, Scarfone, Vanessa M, Nesburn, Anthony B, Wechsler, Steven L, BenMohamed, Lbachir

“…Herpes simplex virus 1 (HSV-1) glycoprotein B (gB)-specific CD8(+) T cells protect mice from herpes infection and disease. However, whether and which HSV-1…”
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Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice by BenMohamed, Lbachir, Osorio, Nelson, Khan, Arif A., Srivastava, Ruchi, Huang, Lei, Krochmal, John J., Garcia, Jairo M., Simpson, Jennifer L., Wechsler, Steven L.

“…Purpose: Blinding ocular herpetic disease in humans is due to spontaneous reactivation of herpes simplex virus type 1 (HSV-1) from latency, rather than to…”
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Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A02:01 Transgenic Mice against Ocular Herpesvirus Infection by Srivastava, Ruchi, Khan, Arif A, Garg, Sumit, Syed, Sabrina A, Furness, Julie N, Vahed, Hawa, Pham, Tiffany, Yu, Howard T, Nesburn, Anthony B, BenMohamed, Lbachir

“…Herpes simplex virus 1 (HSV-1) infection is widespread among humans. The HSV-1 virion protein 13/14 (VP13/14), also known as UL47, is a tegument antigen…”
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Balloon assessment of patent foramen ovale morphology and the modification of tunnels using a balloon detunnelisation technique by Spence, Mark S., Khan, Arif A., Mullen, Michael J.

“…Objectives: (1) To define patent foramen ovale (PFO) morphology using balloon assessment and identify those with long tunnel type morphology. (2) To describe a…”
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Effect of endovascular stenting of aortic coarctation on biventricular function in adults by Lam, Yat-Yin, Kaya, Mehmet G, Li, Wei, Mahadevan, Vaikom S, Khan, Arif A, Henein, Michael Y, Mullen, Michael

“…Objective:To investigate the effect of endovascular stenting of aortic coarctation on biventricular function in adults during intermediate-term…”
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The Herpes Simplex Virus LAT Gene is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained Within The Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits by Benmohamed, Lbachir, Srivastava, Ruchi, Khan, Arif A

“…Persistent pathogens, such as herpes simplex virus type 1 (HSV-1), have evolved a variety of immune evasion strategies to avoid being detected and destroyed by…”
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