Comparison of the incidence and severity of delirium and biochemical factors after coronary artery bypass grafting with dexmedetomidine: A randomized double-blind placebo-controlled clinical trial study

Comparison of the incidence and severity of delirium and biochemical factors after coronary artery bypass grafting with dexmedetomidine: A randomized double-blind placebo-controlled clinical trial study

One of the most common postoperative problems, such as open heart surgery, is delirium, which is responsible for increased mortality and morbidity. Therefore, it is necessary to find a way to cure this disease. The purpose of this study was to assess the effect of dexmedetomidine administration on t...

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Bibliographic Details
Published in:ARYA atherosclerosis Vol. 15; no. 1; pp. 14 - 21
Main Authors: Massoumi, Gholamreza, Mansouri, Mojtaba, Khamesipour, Shima
Format: Journal Article
Language:English
Published: Iran Isfahan Cardiovascular Research Center 01-01-2019
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
Vesnu Publications
Subjects:
Blood pressure
Clinical trials
Coronary Artery Bypass Grafting
Coronary vessels
Critical care
Data collection
Delirium
Dexmedetomidine
Diabetes
Disease prevention
Drug dosages
Family medical history
Heart surgery
Hospitals
Intensive care
Laboratories
Morbidity
Mortality
Narcotics
Original
Studies
Variance analysis
Veins & arteries
Iran
Delirium
Coronary Artery Bypass Grafting
Dexmedetomidine
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Summary:One of the most common postoperative problems, such as open heart surgery, is delirium, which is responsible for increased mortality and morbidity. Therefore, it is necessary to find a way to cure this disease. The purpose of this study was to assess the effect of dexmedetomidine administration on the prevention of delirium after coronary artery bypass grafting (CABG) surgery. This randomized double-blind placebo-controlled clinical trial was performed on 88 patients (44 in the intervention group and 44 in the control group) undertaking CABG surgery. The intervention group was subcutaneously treated with doses of 1 μg/kg of dexmedetomidine for 10 minutes, and 0.2-0.7 μg/kg in hour infusion was applied. The control group underwent normal saline infusion as a placebo. Chi-square and analysis of variance (ANOVA) tests were used to compare the data. Administration of dexmedetomidine in intervention group significantly decreased delirium (P = 0.040) and delirium intensity (P = 0.001). Moreover, patients treated with dexmedetomidine had more stability in laboratory variables and vital signs, and also the duration of hospitalization in these patients was significantly lower than control group (P = 0.002). Considering the efficacy of dexmedetomidine on preventing the incidence and severity of delirium and reducing mortality and morbidity, it is recommended that another study with the larger sample size, with different doses and different prescribing methods be conducted to better understand the effect of this drug and achieve a safe dose with maximum efficacy.
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ISSN:1735-3955
2251-6638
DOI:10.22122/arya.v15i1.1748