Search Results - "Khames, Ahmed"

Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique by Khames, Ahmed

“…BCS class II drugs usually suffer inadequate bioavailability as dissolution step is the absorption rate limiting step. In this work, the effect of solubility…”
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Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability by Khames, Ahmed

“…Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and is prone to extensive liver degradation, it suffers from poor…”
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Ultrasound -guided erector spinae plane block (ESPB) versus intravenous opioids based analgesia in patients with rib fractures by Elmansy, Soha, Abdelkhalek, Mohammed, Farouk, Sherif, Shoukry, Randa, Khames, Ahmed

“…There has been a great interest in the erector spinae plane block (ESPB) to control pain in patients who are presented with rib fractures. ESPB has been shown…”
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Computational Identification of Druggable Bioactive Compounds from Catharanthus roseus and Avicennia marina against Colorectal Cancer by Targeting Thymidylate Synthase by Islam, Md Rashedul, Awal, Md Abdul, Khames, Ahmed, Abourehab, Mohammad A S, Samad, Abdus, Hassan, Walid M I, Alam, Rahat, Osman, Osman I, Nur, Suza Mohammad, Molla, Mohammad Habibur Rahman, Abdulrahman, Abdulrasheed O, Rajia, Sultana, Ahammad, Foysal, Hasan, Md Nazmul, Qadri, Ishtiaq, Kim, Bonglee

“…Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics of the…”
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Analysis and numerical solution of novel fractional model for dengue by Ahmad, Shakoor, Javeed, Shumaila, Ahmad, Hijaz, Khushi, Jamila, Elagan, S.K., Khames, Ahmed

“…Infectious diseases are the major source of increasing death rate during recent years. Among the infectious diseases, dengue fever is disseminated in more than…”
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Berberine Encapsulated Lecithin–Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes by Panda, Dibya Sundar, Eid, Hussein M., Elkomy, Mohammed H., Khames, Ahmed, Hassan, Randa M., Abo El-Ela, Fatma I., Yassin, Heba A.

“…The aim of this research is to formulate a lecithin–chitosan based nanoparticulate system loaded with berberine (BER-LC-CTS-NPs) that could be integrated into…”
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Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors by Hussein, Abdel Haleem M, Khames, Ahmed A, El-Adasy, Abu-Bakr A, Atalla, Ahmed A, Abdel-Rady, Mohamed, Hassan, Mohamed I. A, Nemr, Mohamed T. M, Elshaier, Yaseen A. A. M

“…A new series of 2-aminothiazole derivatives was designed and prepared as phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors. The screening…”
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Synthesis of chitosan-stabilized copper nanoparticles (CS-Cu NPs): Its catalytic activity for C-N and C-O cross-coupling reactions and treatment of bladder cancer by Hongfeng, Zhou, El-Kott, Attalla, Ezzat Ahmed, Ahmed, Khames, Ahmed

“…Herein, we report the synthesis of copper nanoparticles at ambient conditions using biopolymer, chitosan, as a protecting and stabilizing agent and hydrazine…”
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Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors by Venkidath, Anusree, Oh, Jong Min, Dev, Sanal, Amin, Elham, Rasheed, Shebina P., Vengamthodi, Ajeesh, Gambacorta, Nicola, Khames, Ahmed, Abdelgawad, Mohamed A., George, Ginson, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo

“…A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5), and evaluated for their inhibitory profiles of monoamine oxidases (MAOs)…”
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Decorated Cu NPs on Lignin coated magnetic nanoparticles: Its performance in the reduction of nitroarenes and investigation of its anticancer activity in A549 lung cancer cells by Huang, Yongjie, Kang, Yan, El-kott, Attalla, Ahmed, Ahmed Ezzat, Khames, Ahmed, Zein, Mohamed Abdellatif

“…This work describes an eco-friendly approach for in situ immobilization of Cu nanoparticles on the surface of lignin modified Fe3O4 nanoparticles, without…”
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Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity by Hussein, Abdel Haleem M, Khames, Ahmed A, El-Adasy, Abu-Bakr A, Atalla, Ahmed A, Abdel-Rady, Mohamed, Hassan, Mohamed I A, Abou-Salim, Mahrous A, Elshaier, Yaseen A M M, Barakat, Assem

“…The elaboration of new small molecules that target phosphodiesterase enzymes (PDEs), especially those of type 5 (PDE5), is an interesting and emerging topic…”
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Development of Halogenated Pyrazolines as Selective Monoamine Oxidase-B Inhibitors: Deciphering via Molecular Dynamics Approach by Nair, Aathira Sujathan, Oh, Jong-Min, Koyiparambath, Vishal Payyalot, Kumar, Sunil, Sudevan, Sachithra Thazhathuveedu, Soremekun, Opeyemi, Soliman, Mahmoud E., Khames, Ahmed, Abdelgawad, Mohamed A., Pappachen, Leena K., Mathew, Bijo, Kim, Hoon

“…Halogens have been reported to play a major role in the inhibition of monoamine oxidase (MAO), relating to diverse cognitive functions of the central nervous…”
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Calendula officinalis-based green synthesis of titanium nanoparticle: Fabrication, characterization, and evaluation of human colorectal carcinoma by Wei, Xiaojuan, Liu, Yang, El-kott, Attalla, Ahmed, Ahmed Ezzat, Khames, Ahmed

“…Calendula officinalis is a flowering plant with various applications in traditional medicine. The herbal products of the plant are also used in pharmaceuticals…”
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Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase‑B and Butyrylcholinesterase Inhibitors by Rehuman, Nisha Abdul, Oh, Jong Min, Nath, Lekshmi R, Khames, Ahmed, Abdelgawad, Mohamed A, Gambacorta, Nicola, Nicolotti, Orazio, Jat, Rakesh Kumar, Kim, Hoon, Mathew, Bijo

“…A series of halogenated coumarin–chalcones were synthesized, characterized, and their inhibitory activities against monoamine oxidases (MAOs),…”
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Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection by Abourehab, Mohammed A S, Khames, Ahmed, Genedy, Samar, Mostafa, Shahin, Khaleel, Mohammad A, Omar, Mahmoud M, El Sisi, Amani M

“…Nicergoline (NIC) is a semisynthetic ergot alkaloid derivative applied for treatment of dementia and other cerebrovascular disorders. The efficacy of sesame…”
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Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders by Vishal, Vishal Payyalot, Oh, Jong Min, Khames, Ahmed, Abdelgawad, Mohamed A., Nair, Aathira Sujathan, Nath, Lekshmi R., Gambacorta, Nicola, Ciriaco, Fulvio, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo

“…Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their…”
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Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology by Elsayed, Mahmoud M A, Aboelez, Moustafa O, Elsadek, Bakheet E M, Sarhan, Hatem A, Khaled, Khaled Ali, Belal, Amany, Khames, Ahmed, Hassan, Yasser A, Abdel-Rheem, Amany A, Elkaeed, Eslam B, Raafat, Mohamed, Elsadek, Mahmoud Elkot Mostafa

“…Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort…”
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Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections by Fatima, Iman, Rasul, Akhtar, Shah, Shahid, Saadullah, Malik, Islam, Nayyer, Khames, Ahmed, Salawi, Ahmad, Ahmed, Muhammad Masood, Almoshari, Yosif, Abbas, Ghulam, Abourehab, Mohammed A S, Mehmood Khan, Sajid, Chauhdary, Zunera, Alshamrani, Meshal, Namazi, Nader Ibrahim, Naguib, Demiana M

“…The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional…”
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Development and Characterization of Eudragit ® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity by Inam, Sana, Irfan, Muhammad, Lali, Noor Ul Ain, Khalid Syed, Haroon, Asghar, Sajid, Khan, Ikram Ullah, Khan, Salah-Ud-Din, Iqbal, Muhammad Shahid, Zaheer, Imran, Khames, Ahmed, Abou-Taleb, Heba A, Abourehab, Mohammad A S

“…Poor solubility is the major challenge involved in the formulation development of new chemical entities (NCEs), as more than 40% of NCEs are practically…”
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Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain by Hosny, Khaled M., Sindi, Amal M., Alkhalidi, Hala M., Kurakula, Mallesh, Hassan, Amira H., Bakhaidar, Rana B., Abualsunun, Walaa A., Almehmady, Alshaimaa M., Khames, Ahmed, Rizg, Waleed Y., Khallaf, Rasha A., Alruwaili, Nabil K., Alhakamy, Nabil A.

“…The majority of newly developed drugs need to be incorporated with delivery systems to maximize their effect and minimize side effects. Nanoemulsions (NEs) are…”
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