(18)F-DOPA PET/CT and MRI: description of 12 histologically-verified pheochromocytomas

To describe the (18)F-fluorodihydro-xyphenylalanine ((18)F-DOPA), positron emission tomography (PET) and magnetic resonance imaging (MRI) appearance of pheochromocytomas, with a focus on the presence or absence of typical MRI features. Eleven patients with histologically-verified pheochromocytoma [s...

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Bibliographic Details
Published in:	Anticancer research Vol. 34; no. 2; pp. 791 - 795
Main Authors:	Magnaldi, Silvia, Mayerhoefer, Marius E, Khameneh, Ashkan, Schuetz, Matthias, Javor, Domagoj, Mitterhauser, Markus, Dudczak, Robert, Hacker, Marcus, Karanikas, Georgios
Format:	Journal Article
Language:	English
Published:	Greece 01-02-2014
Subjects:	Adrenal Gland Neoplasms - diagnostic imaging Adrenal Gland Neoplasms - pathology Adult Aged Dihydroxyphenylalanine - analogs & derivatives Female Fluorine Radioisotopes Humans Magnetic Resonance Imaging - methods Male Middle Aged Multimodal Imaging - methods Pheochromocytoma - diagnostic imaging Pheochromocytoma - pathology Positron-Emission Tomography - methods Radiopharmaceuticals Retrospective Studies Tomography, X-Ray Computed - methods CT Pheochromocytoma MRI 18F-DOPA PET
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Summary:	To describe the (18)F-fluorodihydro-xyphenylalanine ((18)F-DOPA), positron emission tomography (PET) and magnetic resonance imaging (MRI) appearance of pheochromocytomas, with a focus on the presence or absence of typical MRI features. Eleven patients with histologically-verified pheochromocytoma [sporadic (n=9), multiple endocrine neoplasia (MEN) 2A syndrome (n=2)] were enrolled retrospectively. All patients underwent an MRI examination of the upper abdomen. Nine out of 11 patients underwent (18)F-DOPA PET/CT, and the remaining two patients underwent independent PET and computed tomography (CT) examinations. (18)F-DOPA-PET/CT examinations were considered positive when an increased tracer accumulation in the adrenal region, as shown on CT images, was observed. When an adrenal mass was detected on MRI, the T1 and T2 signal intensity and contrast enhancement pattern were recorded. Based on MR characteristics, the lesions were divided into typical and atypical. Ten out of 11 patients had one lesion, while one patient had two lesions. All pheochromocytomas were detected by both PET/CT and MRI. On (18)F-DOPA scans, all lesions showed an increased tracer accumulation, with a mean maximum standardized uptake value (SUVmax) of 13.7±5.75. Eight out of 12 pheochromocytomas exhibited typical MRI features, with intermediate signal intensity on T1-weighted images in-phase, absence of signal drop on T1-weighted images out-of-phase, high signal intensity on T2-weighted images, and clear contrast enhancement in the arterial phase. The remaining four lesions exhibited atypical MRI features, namely absence of one of the listed criteria. In the assessment of pheochromocytoma, the combination of (18)F-DOPA PET with MRI is superior to MRI-alone. (18)F-DOPA PET/MRI may yield a higher diagnostic confidence for the detection of pheochromocytoma than (18)F-DOPA PET/CT.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1791-7530