Search Results - "Khalsa, Jasneet Kaur"
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Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types
Published in Nature communications (06-08-2020)“…Immunotherapy has emerged as a promising approach to treat cancer, however, its efficacy in highly malignant brain-tumors, glioblastomas (GBM), is limited…”
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Tumor Resection Recruits Effector T Cells and Boosts Therapeutic Efficacy of Encapsulated Stem Cells Expressing IFNβ in Glioblastomas
Published in Clinical cancer research (15-11-2017)“…Despite tumor resection being the first-line clinical care for glioblastoma (GBM) patients, nearly all preclinical immune therapy models intend to treat…”
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Immune Profiling of Syngeneic Murine and Patient GBMs for Effective Translation of Immunotherapies
Published in Cells (Basel, Switzerland) (25-02-2021)“…Immunotherapy for brain tumors remains elusive, unlike many other cancer types for which it is one of the most promising therapeutic options. Recent studies…”
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Salmonella Engages Host MicroRNAs To Modulate SUMOylation: a New Arsenal for Intracellular Survival
Published in Molecular and cellular biology (01-09-2015)“…Posttranslational modifications (PTMs) can alter many fundamental properties of a protein. One or combinations of them have been known to regulate the dynamics…”
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Modulation of Naive CD8 T Cell Response Features by Ligand Density, Affinity, and Continued Signaling via Internalized TCRs
Published in The Journal of immunology (1950) (01-03-2017)“…T cell response magnitudes increase with increasing antigenic dosage. However, it is unclear whether ligand density only modulates the proportions of…”
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Amyloid form of ovalbumin evokes native antigen-specific immune response in the host: prospective immuno-prophylactic potential
Published in The Journal of biological chemistry (13-02-2015)“…Amyloids are highly organized protein aggregates that arise from inappropriately folded versions of proteins or polypeptides under both physiological as well…”
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Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID‐19 related cytokine storm
Published in Stem cells (Dayton, Ohio) (01-06-2021)“…The coronavirus disease 2019 (COVID‐19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent…”
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A role for cell‐autocrine interleukin‐2 in regulatory T‐cell homeostasis
Published in Immunology (01-07-2020)“…Summary Activated T‐cells make both interleukin‐2 (IL2) and its high‐affinity receptor component CD25. Regulatory CD4 T‐cells (Treg cells) do not make IL2, and…”
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Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples
Published in Blood (03-08-2023)“…•Clonal evolution on venetoclax selects for 8p deletion, which leads to increased venetoclax resistance in vitro.•Elevated Erk signaling and constitutively…”
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Functionally significant metabolic differences between B and T lymphocyte lineages
Published in Immunology (01-10-2019)“…Summary Activation of B and T lymphocytes leads to major remodelling of the metabolic landscape of the cells enabling their post‐activation functions. However,…”
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Amyloid Form of Ovalbumin Evokes Native Antigen-specific Immune Response in the Host
Published in The Journal of biological chemistry (13-02-2015)“…Amyloids are highly organized protein aggregates that arise from inappropriately folded versions of proteins or polypeptides under both physiological as well…”
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A role for apoptosis-inducing factor in T cell development
Published in The Journal of experimental medicine (27-08-2012)“…Apoptosis-inducing factor (Aif) is a mitochondrial flavoprotein that regulates cell metabolism and survival in many tissues. We report that aif-hypomorphic…”
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