Search Results - "Khallaf, Rasha A."

Preparation and Optimization of In Situ Gel Loaded with Rosuvastatin-Ellagic Acid Nanotransfersomes to Enhance the Anti-Proliferative Activity by Hosny, Khaled M, Rizg, Waleed Y, Khallaf, Rasha A

“…The objective of this study was to develop an optimized sustained-release nanotransfersomes (NTS) based in situ gel formulation of rosuvastatin (RO) combined…”
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Coconut Oil Nanoemulsion Loaded with a Statin Hypolipidemic Drug for Management of Burns: Formulation and In Vivo Evaluation by Hosny, Khaled M., Alhakamy, Nabil A., Sindi, Amal M., Khallaf, Rasha A.

“…Burn wound healing is a complex process that involves the repair of injured tissues and the control of infection to diminish the scar formation, pain, and…”
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A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization by Salem, Heba F., El-Menshawe, Shahira F., Khallaf, Rasha A., Rabea, Yasmine K.

“…Poor bioavailability of drugs via oral route is the greatest challenge facing drug formulation. To overcome this obstacle, transdermal route was commonly used…”
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Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis by Abdulaal, Wesam H., Hosny, Khaled M., Alhakamy, Nabil A., Bakhaidar, Rana B., Almuhanna, Yasir, Sabei, Fahad Y., Alissa, Mohammed, Majrashi, Mohammed, Alamoudi, Jawaher Abdullah, Hazzazi, Mohannad S., Jafer, Ayman, Khallaf, Rasha A.

“…Low bone mass, degeneration of bone tissue, and disruption of bone microarchitecture are all symptoms of the disease osteoporosis, which can decrease bone…”
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Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain by Hosny, Khaled M., Sindi, Amal M., Alkhalidi, Hala M., Kurakula, Mallesh, Hassan, Amira H., Bakhaidar, Rana B., Abualsunun, Walaa A., Almehmady, Alshaimaa M., Khames, Ahmed, Rizg, Waleed Y., Khallaf, Rasha A., Alruwaili, Nabil K., Alhakamy, Nabil A.

“…The majority of newly developed drugs need to be incorporated with delivery systems to maximize their effect and minimize side effects. Nanoemulsions (NEs) are…”
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Intratracheally Inhalable Nifedipine-Loaded Chitosan-PLGA Nanocomposites as a Promising Nanoplatform for Lung Targeting: Snowballed Protection via Regulation of TGF-β/β-Catenin Pathway in Bleomycin-Induced Pulmonary Fibrosis by Elkomy, Mohammed H, Khallaf, Rasha A, Mahmoud, Mohamed O, Hussein, Raghda R S, El-Kalaawy, Asmaa M, Abdel-Razik, Abdel-Razik H, Aboud, Heba M

“…Pulmonary fibrosis is a serious ailment that may progress to lung remodeling and demolition, where the key participants in its incidence are fibroblasts…”
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Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota by Hosny, Khaled M., Khallaf, Rasha A., Asfour, Hani Z., Rizg, Waleed Y., Alhakamy, Nabil A., Sindi, Amal M., Alkhalidi, Hala M., Abualsunun, Walaa A., Bakhaidar, Rana B., Almehmady, Alshaimaa M., Abdulaal, Wesam H., Bakhrebah, Muhammed A., Alsuabeyl, Mohammed S., K. Kammoun, Ahmed, Alghaith, Adel F., Alshehri, Sultan

“…Oral health is a key contributor to a person’s overall health and well-being. Oral microbiota can pose a serious threat to oral health. Thus, the present study…”
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Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia by Rizg, Waleed Y, Hosny, Khaled M, Elgebaly, Samar S, Alamoudi, Abdulmohsin J, Felimban, Raed I, Tayeb, Hossam H, Alharbi, Majed, Bukhary, Haitham A, Abualsunun, Walaa A, Almehmady, Alshaimaa M, Khallaf, Rasha A

“…Alopecia areata is a scarless, localized hair loss disorder that is typically treated with topical formulations that ultimately only further irritate the…”
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5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment by Khallaf, Rasha A, Salem, Heba F, Abdelbary, Ahmed

“…The effective treatment of skin carcinoma is warranted for targeting the chemotherapeutic agents into tumor cells and avoiding unwanted systemic absorption…”
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Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation by Khallaf, Rasha A., Aboud, Heba M., Sayed, Ossama M.

“…Olanzapine (OL) is an atypical antipsychotic drug which suffers from an extensive hepatic metabolism and poor bioavailability. In addition, it has low brain…”
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Implementing losartan potassium-laden pegylated nanocubic vesicles as a novel nanoplatform to alleviate cisplatin-induced nephrotoxicity via blocking apoptosis and activating the wnt/β-catenin/TCF-4 pathway by Salem, Heba F., Nafady, Mohamed M., Khallaf, Rasha A., Abdel-Sattar, Asmaa Ramadan, Abdel-Sattar, Hend Hassan, Eissa, Essam M.

“…Losartan potassium-laden pegylated nanocubic vesicles (LP-NCVs-PEG) have an intriguing kidney-targeted nanoplatform for acute renal injury via blocking…”
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Assembly of In-Situ Gel Containing Nano-Spanlastics of an Angiotensin II Inhibitor as a Novel Epitome for Hypertension Management: Factorial Design Optimization, In-vitro Gauging, Pharmacokinetics, and Pharmacodynamics Appraisal by Salem, Heba F., Nafady, Mohamed M., Eissa, Essam M., Abdel-Sattar, Hend Hassan, Khallaf, Rasha A.

“…More than 1 billion people worldwide suffer from hypertension; therefore, hypertension management has been categorized as a global health priority. Losartan…”
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Optimization and Appraisal of Chitosan-Grafted PLGA Nanoparticles for Boosting Pharmacokinetic and Pharmacodynamic Effect of Duloxetine HCl Using Box-Benkhen Design by Salem, Heba F, Ali, Adel A, Rabea, Yasmine K, Abo El-Ela, Fatma I, Khallaf, Rasha A

“…Duloxetine HCl (DXH) is a psychiatric medicine employed for treating major depressive disorder. Nonetheless, its low water solubility, high first-pass…”
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Rosuvastatin calcium-based novel nanocubic vesicles capped with silver nanoparticles-loaded hydrogel for wound healing management: optimization employing Box-Behnken design: in vitro and in vivo assessment by Salem, Heba F., Nafady, Mohamed Mahmoud, Ewees, Mohamed Gamal EL-Din, Hassan, Hend, Khallaf, Rasha A.

“…Chronic wounds are a serious problem that could cause severe morbidity and even death. The ability of statins including rosuvastatin calcium (RVS) to enhance…”
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Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase by Hussein, Rasha M., Kandeil, Mohamed A., Mohammed, Norhan A., Khallaf, Rasha A.

“…Curcumin (Cur) is a natural compound that exhibited therapeutic effects against various liver injuries however Cur showed poor water solubility and…”
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Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush by Hosny, Khaled M., Aldawsari, Hibah M., Bahmdan, Rahaf H, Sindi, Amal M., Kurakula, Mallesh, Alrobaian, Majed M., Aldryhim, Ahmed Y., Alkhalidi, Hala M, Bahmdan, Hiba Hisham, Khallaf, Rasha A., El Sisi, Amani M.

“…Miconazole nitrate (MZ) is a BCS class II antifungal poorly water-soluble drug with limited dissolution properties and gastrointestinal side effects…”
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Mucoadhesive niosomal in situ gel for ocular tissue targeting: in vitro and in vivo evaluation of lomefloxacin hydrochloride by Abdelbary, Ahmed, Salem, Heba F., Khallaf, Rasha A., Ali, Ahmed M. A.

“…Eradication of ophthalmic infections depends on increasing transcorneal permeation and localizing antibiotics at ocular surface. This study aimed at…”
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Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal by Salem, Heba F., Ali, Adel A., Rabea, Yasmine K., El-Ela, Fatma I. Abo, Khallaf, Rasha A.

“…Duloxetine HCl (DXH) is a reuptake inhibitor of serotonin and norepinephrine used to treat the major depressive disorder. Following its extensive hepatic…”
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Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation by Abou-Taleb, Heba A, Khallaf, Rasha A, Abdel-Aleem, Jelan A

“…One of the greatest challenges drug formulation is facing is poor bioavailability via oral route. In this regard, nasal drug delivery has been commonly used as…”
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Formulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota by Hosny, Khaled, Asfour, Hani, Rizg, Waleed, Alhakamy, Nabil A, Sindi, Amal, Alkhalidi, Hala, Abualsunun, Walaa, Bakhaidar, Rana, Almehmady, Alshaimaa M, Akeel, Sara, Ali, Sarah, Alghaith, Adel, Alshehri, Sultan, Khallaf, Rasha

“…Introduction: Natural oil-based nanoemulsions (NEs) have been widely investigated in many diseases that affect the oral cavity. NEs are delivery systems that…”
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