Search Results - "Khalili, Jahan S"

Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior by Li, Suyan, Kumar T, Peeyush, Joshee, Sampada, Kirschstein, Timo, Subburaju, Sivan, Khalili, Jahan S, Kloepper, Jonas, Du, Chuang, Elkhal, Abdallah, Szabó, Gábor, Jain, Rakesh K, Köhling, Rüdiger, Vasudevan, Anju

“…The cerebral cortex is essential for integration and processing of information that is required for most behaviors. The exquisitely precise laminar…”
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Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma by KHALILI, Jahan S, SHUJUAN LIU, MIN ZHANG, JOSEPH, Richard W, BERNATCHEZ, Chantale, EKMEKCIOGLU, Suhendan, GRIMM, Elizabeth, RADVANYI, Laszlo G, DAVIS, Richard E, DAVIES, Michael A, WARGO, Jennifer A, HWU, Patrick, RODRIGUEZ-CRUZ, Tania G, LIZEE, Gregory, WHITTINGTON, Mayra, WARDELL, Seth, CHENGWEN LIU, MINYING ZHANG, COOPER, Zachary A, FREDERICK, Dennie T, YUFENG LI

“…In this study, we assessed the specific role of BRAF(V600E) signaling in modulating the expression of immune regulatory genes in melanoma, in addition to…”
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Combination Small Molecule MEK and PI3K Inhibition Enhances Uveal Melanoma Cell Death in a Mutant GNAQ- and GNA11-Dependent Manner by KHALILI, Jahan S, XIAOXING YU, JI WANG, HAYES, Brendan C, DAVIES, Michael A, LIZEE, Gregory, ESMAELI, Bita, WOODMAN, Scott E

“…Activating Q209L/P mutations in GNAQ or GNA11 (GNAQ/11) are present in approximately 80% of uveal melanomas. Mutant GNAQ/11 are not currently therapeutically…”
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Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID‐19 by Khalili, Jahan S., Zhu, Hai, Mak, Nga Sze Amanda, Yan, Yongqi, Zhu, Yi

“…Confronting the challenge of the outbreak of COVID‐19 should sharpen our focus on global drug access as a key issue in antiviral therapy testing. The testing…”
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Natural splice variant of MHC class I cytoplasmic tail enhances dendritic cell-induced CD8+ T-cell responses and boosts anti-tumor immunity by Rodríguez-Cruz, Tania G, Liu, Shujuan, Khalili, Jahan S, Whittington, Mayra, Zhang, Minying, Overwijk, Willem, Lizée, Gregory

“…Dendritic cell (DC)-mediated presentation of MHC class I (MHC-I)/peptide complexes is a crucial first step in the priming of CTL responses, and the cytoplasmic…”
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Human forebrain endothelial cell therapy for psychiatric disorders by Datta, Debkanya, Subburaju, Sivan, Kaye, Sarah, Baruah, Jugajyoti, Choi, Yong Kee, Nian, Yeqi, Khalili, Jahan S., Chung, Sangmi, Elkhal, Abdallah, Vasudevan, Anju

“…Abnormalities of or reductions in GABAergic interneurons are implicated in the pathology of severe neuropsychiatric disorders, for which effective treatments…”
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ACE2-Fc fusion protein overcomes viral escape by potently neutralizing SARS-CoV-2 variants of concern by Tsai, Tsung-I, Khalili, Jahan S., Gilchrist, Mark, Waight, Andrew B., Cohen, Daniella, Zhuo, Shi, Zhang, Yong, Ding, Muran, Zhu, Hai, Mak, Amanda Nga-Sze, Zhu, Yi, Goulet, Dennis R.

“…COVID-19, an infectious disease caused by the SARS-CoV-2 virus, emerged globally in early 2020 and has remained a serious public health issue. To date,…”
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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity by Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, Hwu, Patrick

“…Although immunotherapy has achieved impressive durable clinical responses, many cancers respond only temporarily or not at all to immunotherapy. To find novel,…”
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B-Raf Regulation of Integrin α4β1-mediated Resistance to Shear Stress through Changes in Cell Spreading and Cytoskeletal Association in T Cells by Brown, Wells S., Khalili, Jahan S., Rodriguez-Cruz, Tania G., Lizee, Greg, McIntyre, Bradley W.

“…The regulation of integrin-mediated adhesion is of vital importance to adaptive and innate immunity. Integrins are versatile proteins and mediate T cell…”
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In silico prediction of tumor antigens derived from functional missense mutations of the cancer gene census by Khalili, Jahan S., Hanson, Russell W., Szallasi, Zoltan

“…Antigen-specific immune responses against peptides derived from missense gene mutations have been identified in multiple cancers. The application of…”
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SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity by Park, Jungsun, Talukder, Amjad H, Lim, Seon A, Kim, Kwanghee, Pan, Ke, Melendez, Brenda, Bradley, Sherille D, Jackson, Kyle R, Khalili, Jahan S, Wang, Junmei, Creasy, Caitlin, Pan, Bih-Fang, Woodman, Scott E, Bernatchez, Chantale, Hawke, David, Hwu, Patrick, Lee, Kyung-Mi, Roszik, Jason, Lizée, Gregory, Yee, Cassian

“…Cytotoxic T lymphocyte (CTL)-based immunotherapies have had remarkable success at generating objective clinical responses in patients with advanced metastatic…”
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Forging a link between oncogenic signaling and immunosuppression in melanoma by Khalili, Jahan S., Hwu, Patrick, Lizée, Gregory

“…Immunosuppressive tumor microenvironments limit the efficacy of T cell-based immunotherapy. We have recently demonstrated that the inhibition of BRAF V600E…”
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BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma by Bradley, Sherille D, Chen, Zeming, Melendez, Brenda, Talukder, Amjad, Khalili, Jahan S, Rodriguez-Cruz, Tania, Liu, Shujuan, Whittington, Mayra, Deng, Wanleng, Li, Fenge, Bernatchez, Chantale, Radvanyi, Laszlo G, Davies, Michael A, Hwu, Patrick, Lizée, Gregory

“…Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma,…”
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GNC-038, a tetra-specific antibody, in patients with R/R non-Hodgkin lymphoma or acute lymphoblastic leukemia: A phase 1 study design and rationale by Wang, Jianxiang, Qi, Junyuan, Li, Wenyu, Zhai, Zhimin, Li, Ping, Zou, Wen, Ding, Muran, Yang, Xue, Wang, Rong, Guo, Wanjing, Xiao, Sa, Khalili, Jahan S., Zhu, Hai, Olivo, Martin Sebastian, Zhu, Yi

“…TPS2668 Background: Bispecific T cell engagers can mediate single antigen-specific cell cytolysis, but cannot preempt clonal relapse, or modify the…”
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Natural Splice Variant of MHC Class I Cytoplasmic Tail Enhances Dendritic Cell-Induced CD8.sup.+ T-Cell Responses and Boosts Anti-Tumor Immunity by Rodríguez-Cruz, Tania G, Liu, Shujuan, Khalili, Jahan S, Whittington, Mayra, Zhang, Minying, Overwijk, Willem, Lizée, Gregory

“…Dendritic cell (DC)-mediated presentation of MHC class I (MHC-I)/peptide complexes is a crucial first step in the priming of CTL responses, and the cytoplasmic…”
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Regulatory and Naïve T Cells in Unmanipulated Donor Grafts Are Not Associated with Acute Graft Vs Host Disease in Matched Sibling Transplants for AML by Khalili, Jahan S., Saliba, Rima M, John, Lisa St, Alousi, Amin, Wieder, Eric D., De Lima, Marcos, Champlin, Richard, Molldrem, Jeffrey J., Shpall, E.J., McMannis, John, Komanduri, Krishna V.

“…Acute graft-versus-host disease (aGVHD) occurs in approximately 20–50% of matched-related stem cell transplants (HCT). The presence of increased frequencies of…”
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Regulatory and Naïve T Cells in Unmanipulated Donor Grafts Are Not Associated with Acute Graft Vs Host Disease in Matched Sibling Transplants for AML by Khalili, Jahan S., Saliba, Rima M, John, Lisa St, Alousi, Amin, Wieder, Eric D., De Lima, Marcos, Champlin, Richard, Molldrem, Jeffrey J., Shpall, E. J., McMannis, John, Komanduri, Krishna V.

“…Abstract Acute graft-versus-host disease (aGVHD) occurs in approximately 20–50% of matched-related stem cell transplants (HCT). The presence of increased…”
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In silico prediction of tumor antigens derived from functional missense mutations of the cancer gene census by Zoltan Szallasi, Jahan S. Khalili, Russell W. Hanson

“…Antigen-specific immune responses against peptides derived from missense gene mutations have been identified in multiple cancers. The application of…”
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