Evaluation of serum presepsin, procalcitonin, copeptin, and high-sensitivity C-reactive protein for differentiating bacterial infection from disease activity in Egyptian patients with systemic lupus erythematosus

Evaluation of serum presepsin, procalcitonin, copeptin, and high-sensitivity C-reactive protein for differentiating bacterial infection from disease activity in Egyptian patients with systemic lupus erythematosus

Objectives Several biological markers have been studied for the differentiation of infection from disease activity in systemic lupus erythematosus (SLE) patients with discrepant results. We aimed to evaluate the role of serum presepsin, hs-CRP, procalcitonin (PCT), and copeptin (CPP) in differentiat...

Full description

Saved in:
Bibliographic Details
Published in:Clinical rheumatology Vol. 40; no. 5; pp. 1861 - 1869
Main Authors: AlJarhi, Ula M., Sadek, Khaled Marzouk, Darwish, Enas M., Elmessiery, Riem M., Salem, Khaled, Khalil, Sanaa A., Seif El Nasr, Sayed M., Kamel, Mahmoud F., Hesham, Dina, Fayed, Ahmed
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01-05-2021
Springer Nature B.V
Subjects:
Bacteria
Bacterial infections
Bacterial Infections - diagnosis
Biomarkers
C-reactive protein
C-Reactive Protein - analysis
Calcitonin
Cross-Sectional Studies
Egypt
Glycopeptides
Humans
Infections
Inflammation
Lipopolysaccharide Receptors
Lupus
Lupus Erythematosus, Systemic - diagnosis
Medicine
Medicine & Public Health
Original Article
Peptide Fragments
Procalcitonin
Rheumatology
Serum levels
Systemic lupus erythematosus
Egypt
Hs-CRP
Presepsin
Lupus activity
Procalcitonin
Copeptin
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Several biological markers have been studied for the differentiation of infection from disease activity in systemic lupus erythematosus (SLE) patients with discrepant results. We aimed to evaluate the role of serum presepsin, hs-CRP, procalcitonin (PCT), and copeptin (CPP) in differentiating bacterial infections from disease activity in SLE patients. Methods This study is a cross-sectional observational study in which 94 Egyptian patients were recruited from June 2017 to January 2018. Our patients were divided into two groups: group (1) included 48 patients with active SLE hospitalized with any sort of lupus activity and group (2) included 46 patients with active SLE admitted with a proven bacterial infection. Hs-CRP, presepsin, PCT, and CPP were measured using enzyme-linked immune sorbent assay technique. Results Hs-CRP, presepsin, PCT, and CPP were highly significantly higher among group (2) patients compared to group (1) patients ( p  < 0.001). Serum presepsin expressed higher specificity than hs-CRP (87.5% vs 60.4%) but the same sensitivity (80.4%) in the detection of bacterial infection in SLE patients. Serum PCT expressed higher specificity than hs-CRP (100% vs 60.4%) but lower sensitivity (73.9% vs 80.4%). Serum CPP expressed higher specificity than hs-CRP (65.9% vs 60.4%) but lower sensitivity (65.9% vs 80.4%). Conclusion Our study suggests that increased serum levels of hs-CRP, presepsin and PCT levels are useful in differentiating bacterial infections from disease activity in SLE patients. Serum CPP could be used as an adjunct with more specific inflammatory biomarkers in making better diagnostic judgments. Key Points: • The increased serum levels of hs-CRP, presepsin and PCT levels are useful in differentiating bacterial infections from disease activity in SLE patients. • Serum Presepsin expressed higher specificity than hs-CRP but the same sensitivity in the detection of bacterial infection in SLE patients. • Serum CPP expressed higher specificity than hs-CRP but lower sensitivity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
content type line 23
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-020-05471-z