Search Results - "Khalil, Raouf A"

Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease by Liu, Zhongwei, Khalil, Raouf A.

“…[Display omitted] Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function. Identifying the mechanisms of VSM contraction…”
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Inflammatory cytokines in vascular dysfunction and vascular disease by Sprague, Alexander H., Khalil, Raouf A.

“…The vascular inflammatory response involves complex interaction between inflammatory cells (neutrophils, lymphocytes, monocytes, macrophages), endothelial…”
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Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins by Kucukguven, Arda, Khalil, Raouf A

“…Varicose veins (VVs) are a common venous disease of the lower extremity characterized by incompetent valves, venous reflux, and dilated and tortuous veins. If…”
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Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment by Raffetto, Joseph D, Ligi, Daniela, Maniscalco, Rosanna, Khalil, Raouf A, Mannello, Ferdinando

“…Venous leg ulcers (VLUs) are one of the most common ulcers of the lower extremity. VLU affects many individuals worldwide, could pose a significant…”
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Vascular endothelin receptor type B: Structure, function and dysregulation in vascular disease by Mazzuca, Marc Q., Khalil, Raouf A.

“…Endothelin-1 (ET-1) is a major regulator of vascular function, acting via both endothelin receptor type A (ETAR) and type B (ETBR). Although the role of ETAR…”
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Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease by Benjamin, Mina M, Khalil, Raouf A

“…Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various components of the extracellular matrix (ECM). MMPs could also regulate the…”
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Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy by Zhu, Minglin, Ren, Zongli, Possomato-Vieira, José S, Khalil, Raouf A

“…Preeclampsia (PE) is a pregnancy-related hypertensive disorder (HTN-Preg) with unclear mechanism. An imbalance between antiangiogenic soluble fms-like tyrosine…”
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Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia by Yu, Wentao, Gao, Wei, Rong, Dan, Wu, Zhixian, Khalil, Raouf A.

“…Preeclampsia is a pregnancy‐related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are…”
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Gender, sex hormones, and vascular tone by Orshal, Julia M, Khalil, Raouf A

“…The greater incidence of hypertension and coronary artery disease in men and postmenopausal women compared with premenopausal women has been related, in part,…”
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Sex Difference in Cardiovascular Risk by Regnault, Véronique, PhD, Thomas, Frédérique, PhD, Safar, Michel E., MD, Osborne-Pellegrin, Mary, PhD, Khalil, Raouf A., MD, Pannier, Bruno, MD, Lacolley, Patrick, MD

“…Objectives The study was to explore whether the brachial/carotid pulse pressure (B/C-PP) ratio selectively predicts the sex difference in age-related…”
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Sex Hormones as Potential Modulators of Vascular Function in Hypertension by Khalil, Raouf A

“…The greater incidence of hypertension in men and postmenopausal women compared with premenopausal women has suggested gender differences in vascular function…”
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EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone by Dang, Yiping, Li, Wei, Tran, Victoria, Khalil, Raouf A.

“…Pregnancy is associated with uteroplacental and vascular remodeling in order to adapt for the growing fetus and the hemodynamic changes in the maternal…”
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Biochemical and Biological Attributes of Matrix Metalloproteinases by Cui, Ning, Hu, Min, Khalil, Raouf A

“…Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are involved in the degradation of various proteins in the extracellular…”
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Cellular mediators of renal vascular dysfunction in hypertension by Ponnuchamy, Bharathy, Khalil, Raouf A

“…The renal vasculature plays a major role in the regulation of renal blood flow and the ability of the kidney to control the plasma volume and blood pressure…”
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Vascular effects of estrogenic menopausal hormone therapy by Reslan, Ossama M, Khalil, Raouf A

“…Cardiovascular disease (CVD) is more common in men and postmenopausal women (Post-MW) than premenopausal women (Pre-MW). Despite recent advances in preventive…”
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Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat by Mazzuca, Marc Q, Mata, Karina M, Li, Wei, Rangan, Sridhar S, Khalil, Raouf A

“…Estrogen interacts with estrogen receptors (ERs) to induce vasodilation, but the ER subtype and post-ER relaxation pathways are unclear. We tested if ER…”
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Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension by Salamanca, Daisy A., Khalil, Raouf A.

“…Vascular contraction is an important determinant of the peripheral vascular resistance and blood pressure. The mechanisms underlying vascular smooth muscle…”
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Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia by Chen, Juanjuan, Khalil, Raouf A

“…Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing…”
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Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension by Khalil, Raouf A

“…Endothelin (ET) is one of the most investigated molecules in vascular biology. Since its discovery two decades ago, several ET isoforms, receptors, signaling…”
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Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease by Masood, Durr-e-Nayab, Roach, Emir C, Beauregard, Katie G, Khalil, Raouf A

“…Epidemiological studies have shown that cardiovascular disease (CVD) is less common in pre-menopausal women (Pre-MW) compared to men of the same age or…”
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