Search Results - "Khalil, Insaf F."

Occurrence of the Southeast Asian/South American SVMNT Haplotype of the Chloroquine-Resistance Transporter Gene in Plasmodium falciparum in Tanzania by Alifrangis, Michael, Dalgaard, Michael B., Lusingu, John P., Vestergaard, Lasse S., Staalsoe, Trine, Jensen, Anja T. R., Enevold, Anders, Rønn, Anita M., Khalil, Insaf F., Warhurst, David C., Lemnge, Martha M., Theander, Thor G., Bygbjerg, Ib C.

“…Two main haplotypes, CVIET and SVMNT, of the Plasmodium falciparum chloroquine-resistance transporter gene (Pfcrt) are linked to 4-aminoquinoline resistance…”
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Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations by Khalil, Insaf F, Alifrangis, Michael, Recke, Camilla, Hoegberg, Lotte C, Ronn, Anita, Bygbjerg, Ib C, Koch, Claus

“…In Central and South America and Eastern and Southern Africa, Plasmodium vivax infections accounts for 71-81% and 5% of malaria cases, respectively. In these…”
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Independent Introduction of Two Lactase-Persistence Alleles into Human Populations Reflects Different History of Adaptation to Milk Culture by Enattah, Nabil Sabri, Jensen, Tine G.K., Nielsen, Mette, Lewinski, Rikke, Kuokkanen, Mikko, Rasinpera, Heli, El-Shanti, Hatem, Seo, Jeong Kee, Alifrangis, Michael, Khalil, Insaf F., Natah, Abdrazak, Ali, Ahmed, Natah, Sirajedin, Comas, David, Mehdi, S. Qasim, Groop, Leif, Vestergaard, Else Marie, Imtiaz, Faiqa, Rashed, Mohamed S., Meyer, Brian, Troelsen, Jesper, Peltonen, Leena

“…The T −13910 variant located in the enhancer element of the lactase ( LCT) gene correlates perfectly with lactase persistence (LP) in Eurasian populations…”
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The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics by A-Elbasit, Ishraga E, Alifrangis, Michael, Khalil, Insaf F, Bygbjerg, Ib C, Masuadi, Emad M, Elbashir, Mustafa I, Giha, Hayder A

“…The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The…”
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A fixed-dose 24-hour regimen of artesunate plus sulfamethoxypyrazine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan by Adam, Ishag, Magzoub, Mamoun, Osman, Maha E, Khalil, Insaf F, Alifrangis, Michael, Elmardi, Khalid A

“…Artemisinin-based combination therapy is increasingly being adopted as first-line antimalarial therapy. The choice of appropriate therapy depends on efficacy,…”
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Short Report : Five-Year Surveillance of Molecular Markers of Plasmodium falciparum Antimalarial Drug Resistance in Korogwe District, Tanzania: Accumulation of the 581G Mutation in the P. falciparum Dihydropteroate Synthase Gene by ALIFRANGIS, Michael, LUSINGU, John P, MMBANDO, Bruno, DALGAARD, Michael B, VESTERGAARD, Lasse S, ISHENGOMA, Deus, KHALIL, Insaf F, THEANDER, Thor G, LEMNGE, Martha M, BYGBJERG, Ib C

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Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection by Khalil, Insaf F., Abildrup, Ulla, Alifrangis, Lene H., Maiga, Deogratius, Alifrangis, Michael, Hoegberg, Lotte, Vestergaard, Lasse S., Persson, Ola Per-Eric, Nyagonde, Nyagonde, Lemnge, Martha M., Theander, Thor G., Bygbjerg, Ib C.

“…Artemether-lumefantrine (ARM-LUM) has in recent years become the first-line treatment for uncomplicated malaria in many Sub-Saharan African countries. Vigorous…”
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A simple, high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum chloroquine resistance transporter genes using polymerase chain reaction- and enzyme-linked immunosorbent assay-based technology by Alifrangis, Michael, Enosse, Sonia, Pearce, Richard, Drakeley, Chris, Roper, Cally, Khalil, Insaf F, Nkya, Watoky Mmm, Rønn, Anita M, Theander, Thor G, Bygbjerg, Ib C

“…Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum dihydrofolate reductase (dhfr), and dihydropteroate synthetase (dhps), and chloroquine…”
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The efficacy of sulfadoxine–pyrimethamine alone and in combination with chloroquine for malaria treatment in rural Eastern Sudan: the interrelation between resistance, age and gametocytogenesis by A‐Elbasit, Ishraga E., Elbashir, Mustafa I., Khalil, Insaf F., Alifrangis, Michael, Giha, Hayder A.

“…Summary Objective  To compare the efficacy of sulfadoxine–pyremethamine (SP) + chloroquine (CQ) combination treatment against falciparum malaria with SP…”
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Falciparum malaria in the north of Laos: the occurrence and implications of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene haplotype SVMNT by Dittrich, Sabine, Alifrangis, Michael, Stohrer, Jörg M, Thongpaseuth, Vonthalom, Vanisaveth, Viengxay, Phetsouvanh, Rattanaxay, Phompida, Samlane, Khalil, Insaf F, Jelinek, Tomas

“…Summary Objective  The Pfcrt‐gene encodes a transmembrane protein located in the Plasmodium falciparum digestive vacuole. Chloroquine resistant (CQR) strains…”
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Prediction of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: a comparative study between sites of differing endemicity by Alifrangis, Michael, Enosse, Sonja, Khalil, Insaf F, Tarimo, Donath S, Lemnge, Martha M, Thompson, Richardo, Bygbjerg, Ib C, Rønn, Anita M

“…Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) is due to mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase…”
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Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets by Alifrangis, Michael, Lemnge, Martha M, Rønn, Anita M, Segeja, Method D, Magesa, Stephen M, Khalil, Insaf F, Bygbjerg, Ib C

“…In Magoda and Mpapayu villages in Tanzania, we have previously found comparable high prevalence of Plasmodium falciparum resistance to…”
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Five-Year Surveillance of Molecular Markers of Plasmodium falciparum Antimalarial Drug Resistance in Korogwe District, Tanzania: Accumulation of the 581G Mutation in the P. falciparum Dihydropteroate Synthase Gene by Alifrangis, Michael, Lusingu, John P, Mmbando, Bruno, Dalgaard, Michael B, Vestergaard, Lasse S, Ishengoma, Deus, Khalil, Insaf F, Theander, Thor G, Lemnge, Martha M, Bygbjerg, Ib C

“…In January 2007, Tanzania replaced sulfadoxine-pyrimethamine (SP) with artemether-lumefantrine for treatment of uncomplicated malaria. This study examined the…”
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Response of Plasmodium falciparum to cotrimoxazole therapy: relationship with plasma drug concentrations and dihydrofolate reductase and dihydropteroate synthase genotypes by Khalil, Insaf F, Rønn, Anita M, Alifrangis, Michael, Gabar, Hytham A, Jelinek, Thomas, Satti, Gwiria M H, Bygbjerg, Ib C

“…We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate…”
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Effects of sewage disposal into the White Nile on the plankton community by ABDELLATIF, E. M, ALI, O. M, KHALIL, I. F, NYONJE, B. M

“…Twenty water samples and 30 plankton samples were taken from the sewage disposal site (El Lambab, south of Khartoum) and from 250 m upstream and downstream of…”
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Occurrence of the southeast asian/ south american SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium fakiparum in tanzania by ALIFRANGIS, Michael, DALGAARD, Michael B, LEMNGE, Martha M, THEANDER, Thor G, BYGBJERG, Ib C, LUSINGU, John P, VESTERGAARD, Lasse S, STAALSOE, Trine, JENSEN, Anja T. R, ENEVOLD, Anders, RENN, Anita M, KHALIL, Insaf F, WARHURST, David C

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