Search Results - "Khalil, Eltahir A."

Leishmania blood parasite dynamics during and after treatment of visceral leishmaniasis in Eastern Africa: A pharmacokinetic-pharmacodynamic model by Verrest, Luka, Monnerat, Séverine, Musa, Ahmed M, Mbui, Jane, Khalil, Eltahir A G, Olobo, Joseph, Wasunna, Monique, Chu, Wan-Yu, Huitema, Alwin D R, Schallig, Henk D F H, Alves, Fabiana, Dorlo, Thomas P C

“…With the current treatment options for visceral leishmaniasis (VL), recrudescence of the parasite is seen in a proportion of patients. Understanding parasite…”
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First generation leishmaniasis vaccines: A review of field efficacy trials by Noazin, Sassan, Modabber, Farrokh, Khamesipour, Ali, Smith, Peter G, Moulton, Lawrence H, Nasseri, Kiumarss, Sharifi, Iraj, Khalil, Eltahir A.G, Bernal, Ivan Dario Velez, Antunes, Carlos M.F, Kieny, Marie Paule, Tanner, Marcel

“…Abstract First generation candidate vaccines against leishmaniasis, prepared using inactivated whole parasites as their main ingredient, were considered as…”
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Safety and efficacy of single dose versus multiple doses of AmBisome for treatment of visceral leishmaniasis in eastern Africa: a randomised trial by Khalil, Eltahir A G, Weldegebreal, Teklu, Younis, Brima M, Omollo, Raymond, Musa, Ahmed M, Hailu, Workagegnehu, Abuzaid, Abuzaid A, Dorlo, Thomas P C, Hurissa, Zewdu, Yifru, Sisay, Haleke, William, Smith, Peter G, Ellis, Sally, Balasegaram, Manica, EL-Hassan, Ahmed M, Schoone, Gerard J, Wasunna, Monique, Kimutai, Robert, Edwards, Tansy, Hailu, Asrat

“…Anti-leishmanial drug regimens that include a single dose AmBisome could be suitable for eastern African patients with symptomatic visceral leishmaniasis (VL)…”
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Survey of causative agents for acute respiratory infections among patients in Khartoum-State, Sudan, 2010-2011 by Enan, Khalid A, Nabeshima, Takeshi, Kubo, Toru, Buerano, Corazon C, El Hussein, Abdel Rahim M, Elkhidir, Isam M, Khalil, Eltahir A G, Morita, Kouichi

“…This study was carried out to determine causative agents of acute respiratory illness of patients in Khartoum State, Sudan. Four hundred patients experiencing…”
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Safety and efficacy of miltefosine alone and in combination with sodium stibogluconate and liposomal amphotericin B for the treatment of primary visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial by Omollo, Raymond, Alexander, Neal, Edwards, Tansy, Khalil, Eltahir A G, Younis, Brima M, Abuzaid, Abuzaid A, Wasunna, Monique, Njoroge, Njenga, Kinoti, Dedan, Kirigi, George, Dorlo, Thomas P C, Ellis, Sally, Balasegaram, Manica, Musa, Ahmed M

“…Treatment options for visceral leishmaniasis (VL) in East Africa are far from satisfactory due to cost, toxicity, prolonged treatment duration or emergence of…”
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Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis by Kip, Anke E, Wasunna, Monique, Alves, Fabiana, Schellens, Jan H M, Beijnen, Jos H, Musa, Ahmed M, Khalil, Eltahir A G, Dorlo, Thomas P C

“…The parasite resides and replicates within host macrophages during visceral leishmaniasis (VL). This study aimed to evaluate neopterin, a marker of macrophage…”
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Ovarian Cancer: Tumor-Specific Urinary Micro-Peptides Profiling as Potential Biomarkers for Early Diagnosis by Murgan, Sulafa S, Abd Elaziz, Faisal J, Nasr, Abubakr M A, Elfaki, Mona E E, Khalil, Eltahir A G

“…Ovarian cancer is the second major lethal gynecologic malignancy in developing countries. This study aimed to characterize urinary micro-peptides as potential…”
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Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan by Miller, E Nancy, Fadl, Manal, Mohamed, Hiba S, Elzein, Abier, Jamieson, Sarra E, Cordell, Heather J, Peacock, Christopher S, Fakiola, Michaela, Raju, Madhuri, Khalil, Eltahir A, Elhassan, Ahmed, Musa, Ahmed M, Ibrahim, Muntaser E, Blackwell, Jenefer M

“…Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan…”
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Paromomycin and Miltefosine Combination as an Alternative to Treat Patients With Visceral Leishmaniasis in Eastern Africa: A Randomized, Controlled, Multicountry Trial by Musa, Ahmed M, Mbui, Jane, Mohammed, Rezika, Olobo, Joseph, Ritmeijer, Koert, Alcoba, Gabriel, Muthoni Ouattara, Gina, Egondi, Thaddaeus, Nakanwagi, Prossy, Omollo, Truphosa, Wasunna, Monique, Verrest, Luka, Dorlo, Thomas P C, Musa Younis, Brima, Nour, Ali, Taha Ahmed Elmukashfi, Elmukashfi, Ismail Omer Haroun, Ahmed, Khalil, Eltahir A G, Njenga, Simon, Fikre, Helina, Mekonnen, Tigist, Mersha, Dagnew, Sisay, Kasaye, Sagaki, Patrick, Alvar, Jorge, Solomos, Alexandra, Alves, Fabiana

“…Abstract Background This study aimed to determine whether paromomycin plus miltefosine (PM/MF) is noninferior to sodium stibogluconate plus paromomycin…”
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Safety and immunogenicity of ChAd63-KH vaccine in post-kala-azar dermal leishmaniasis patients in Sudan by Younis, Brima M., Osman, Mohamed, Khalil, Eltahir A.G., Santoro, Francesco, Furini, Simone, Wiggins, Rebecca, Keding, Ada, Carraro, Monica, Musa, Anas E.A., Abdarahaman, Mujahid A.A., Mandefield, Laura, Bland, Martin, Aebischer, Toni, Gabe, Rhian, Layton, Alison M., Lacey, Charles J.N., Kaye, Paul M., Musa, Ahmed M.

“…Post-kala-azar dermal leishmaniasis (PKDL) is a chronic, stigmatizing skin condition occurring frequently after apparent clinical cure from visceral…”
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Blood Parasite Load as an Early Marker to Predict Treatment Response in Visceral Leishmaniasis in Eastern Africa by Verrest, Luka, Kip, Anke E, Musa, Ahmed M, Schoone, Gerard J, Schallig, Henk D F H, Mbui, Jane, Khalil, Eltahir A G, Younis, Brima M, Olobo, Joseph, Were, Lilian, Kimutai, Robert, Monnerat, Séverine, Cruz, Isra, Wasunna, Monique, Alves, Fabiana, Dorlo, Thomas P C

“…Abstract Background To expedite the development of new oral treatment regimens for visceral leishmaniasis (VL), there is a need for early markers to evaluate…”
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Aflatoxin M1 in breast milk of nursing Sudanese mothers by Elzupir, Amin O, Abas, Abdel rouf A, Fadul, M. Hemmat, Modwi, Abueliz K, Ali, Nima M. I, Jadian, Afaf F. F, Ahmed, Nuha Abd A, Adam, Smah Y. A, Ahmed, Nousiba A. M, Khairy, Arwa A. A, Khalil, Eltahir A. G

“…The presence of aflatoxin M1 (AFM1) in the breast milk of nursing Sudanese mothers was investigated using AOAC official method 980.21 as the extraction method…”
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Single-dose liposomal amphotericin B (AmBisome®) for the treatment of visceral leishmaniasis in East Africa: study protocol for a randomized controlled trial by Edwards, Tansy, Omollo, Raymond, Khalil, Eltahir A G, Yifru, Sisay, Musa, Brima, Musa, Ahmed, Wasunna, Monique, Smith, Peter G, Royce, Catherine, Ellis, Sally, Balasegaram, Manica, Hailu, Asrat

“…AmBisome® is an efficacious, safe anti-leishmanial treatment. There is growing interest in its use, either as a single dose or in combination treatments. In…”
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Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients by Verrest, Luka, Wasunna, Monique, Kokwaro, Gilbert, Aman, Rashid, Musa, Ahmed M., Khalil, Eltahir A. G., Mudawi, Mahmoud, Younis, Brima M., Hailu, Asrat, Hurissa, Zewdu, Hailu, Workagegnehu, Tesfaye, Samson, Makonnen, Eyasu, Mekonnen, Yalemtsehay, Huitema, Alwin D. R., Beijnen, Jos H., Kshirsagar, Smita A., Chakravarty, Jaya, Rai, Madhukar, Sundar, Shyam, Alves, Fabiana, Dorlo, Thomas P. C.

“…Introduction Intramuscular paromomycin monotherapy to treat visceral leishmaniasis (VL) has been shown to be effective for Indian patients, while a similar…”
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Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study by Dorlo, Thomas P C, Kip, Anke E, Younis, Brima M, Ellis, Sally J, Alves, Fabiana, Beijnen, Jos H, Njenga, Simon, Kirigi, George, Hailu, Asrat, Olobo, Joseph, Musa, Ahmed M, Balasegaram, Manica, Wasunna, Monique, Karlsson, Mats O, Khalil, Eltahir A G

“…Low efficacy of miltefosine in the treatment of visceral leishmaniasis was recently observed in Eastern Africa. To describe the pharmacokinetics and establish…”
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Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme by Kimutai, Robert, Musa, Ahmed M., Njoroge, Simon, Omollo, Raymond, Alves, Fabiana, Hailu, Asrat, Khalil, Eltahir A. G., Diro, Ermias, Soipei, Peninah, Musa, Brima, Salman, Khalid, Ritmeijer, Koert, Chappuis, Francois, Rashid, Juma, Mohammed, Rezika, Jameneh, Asfaw, Makonnen, Eyasu, Olobo, Joseph, Okello, Lawrence, Sagaki, Patrick, Strub, Nathalie, Ellis, Sally, Alvar, Jorge, Balasegaram, Manica, Alirol, Emilie, Wasunna, Monique

“…Introduction In 2010, WHO recommended a new first-line treatment for visceral leishmaniasis (VL) in Eastern Africa. The new treatment, a combination of…”
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Smear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan by Andres, Sönke, Lonnroth, Knut, Richter, Elvira, Niemann, Stefan, Kranzer, Katharina, Homolka, Susanne, Abdalla, Mohamed A., Mohamed-Noor, Saad E., Bakheit, Mohammed A. M., Wieler, Lothar H., Schaible, Ulrich E., Khidir, Selma Abdelmoneim, Shuaib, Yassir Adam, Hillemann, Doris

“…Background. In Sudan, tuberculosis diagnosis largely relies on clinical symptoms and smear microscopy as in many other low- and middle-income countries. The…”
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Visceral leishmaniasis-hepatitis B/C coinfections: a rising necessity to triage patients for treatment by A, Abubakr O, M, Mohamed M, A, Hatim A, Elamin, Mohamed Y, Younis, Brima M, E, Mona E, Musa, Ahmed M, Elhassan, Ahmed M, G, Eltahir A

“…Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In Sudan, VL is caused by L donovani. Most drugs used to treat VL,…”
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The economic burden of visceral leishmaniasis in Sudan: an assessment of provider and household costs by Meheus, Filip, Abuzaid, Abuzaid A, Baltussen, Rob, Younis, Brima M, Balasegaram, Manica, Khalil, Eltahir A G, Boelaert, Marleen, Musa, Ahmed M

“…Visceral leishmaniasis (VL) is a neglected parasitic disease that is fatal if left untreated and is endemic in eastern Sudan. We estimated the direct and…”
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The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis by Wasunna, Monique, Musa, Ahmed, Hailu, Asrat, Khalil, Eltahir A. G., Olobo, Joseph, Juma, Rashid, Wells, Susan, Alvar, Jorge, Balasegaram, Manica

“…Visceral leishmaniasis is a neglected tropical disease endemic in East Africa where improved patient-adapted treatments are needed. The Leishmaniasis East…”
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