Search Results - "Khalifa, Rym"
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Neutralizing Nanobodies against Venoms from Naja haje Species Captured in North Africa
Published in Toxins (14-09-2024)“…Snakebite envenoming (SBE) remains a severely neglected public health issue, particularly affecting tropical and subtropical regions, with Africa experiencing…”
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Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels
Published in The Journal of biological chemistry (05-04-1996)“…Sodium channels posses receptor sites for many neurotoxins, of which several groups were shown to inhibit sodium current inactivation. Receptor sites that bind…”
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The effect of oxysterols on nerve impulses
Published in Biochimie (01-10-2018)“…The propagation of nerve impulses in myelinated nerve fibers depends on a number of factors involving the myelin and neural axons. In several neurodegenerative…”
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Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes
Published in Chemistry and physics of lipids (01-10-2017)“…•7-ketocholesterol and 24S-hydroxycholesterol induce apoptosis on 158N murine oligodendrocytes.•C24:0 induces necrosis on 158N murine…”
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Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0)
Published in Biochimie (01-10-2018)“…Little is known about K+ regulation playing major roles in the propagation of nerve impulses, as well as in apoptosis and inflammasome activation involved in…”
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A Recombinant Insect‐Specific α‐Toxin of Buthus occitanus tunetanus Scorpion Confers Protection Against Homologous Mammal Toxins
Published in European Journal of Biochemistry (15-06-1996)“…We have constructed a cDNA library from venom glands of the scorpion Buthus occitanus tunetanus and cloned a DNA sequence that encodes an α‐toxin. This clone…”
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Action of Babycurus-toxin 1 from the East African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon
Published in Toxicon (Oxford) (01-07-1997)“…A toxin named babycurus-toxin 1 (mol. wt 8191), from telson extracts of the scorpion Babycurus centrurimorphus, was found to depolarize the cockroach giant…”
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Kbot1, a three disulfide bridges toxin from Buthus occitanus tunetanus venom highly active on both SK and Kv channels
Published in Peptides (New York, N.Y. : 1980) (01-04-2004)“…On attempts to identify toxins showing original profile of activity among K + channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium…”
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α-Scorpion Toxins Binding on Rat Brain and Insect Sodium Channels Reveal Divergent Allosteric Modulations by Brevetoxin and Veratridine (∗)
Published in The Journal of biological chemistry (23-06-1995)“…At least six topologically separated neurotoxin receptor sites have been identified on sodium channels that reveal strong allosteric interactions among them…”
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In vitro folding and functional analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli
Published in Protein expression and purification (01-06-1997)“…The selective toxicity of depressant scorpion neurotoxins to insects is useful in studying insect sodium channel gating and has an applied potential. In order…”
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In VitroFolding and Functional Analysis of an Anti-insect Selective Scorpion Depressant Neurotoxin Produced inEscherichia coli
Published in Protein expression and purification (01-06-1997)“…The selective toxicity of depressant scorpion neurotoxins to insects is useful in studying insect sodium channel gating and has an applied potential. In order…”
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Scorpion Toxins Binding on Rat Brain and Insect Sodium Channels Reveal Divergent Allosteric Modulations by Brevetoxin and Veratridine
Published in The Journal of biological chemistry (23-06-1995)“…At least six topologically separated neurotoxin receptor sites have been identified on sodium channels that reveal strong allosteric interactions among them…”
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