Search Results - "Khaled Qanud"
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Organ- and function-specific anatomical organization of vagal fibers supports fascicular vagus nerve stimulation
Published in Brain stimulation (01-03-2023)“…Vagal fibers travel inside fascicles and form branches to innervate organs and regulate organ functions. Existing vagus nerve stimulation (VNS) therapies…”
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Editorial: Cardiovascular neuromodulation: mechanisms and therapies
Published in Frontiers in cardiovascular medicine (23-05-2023)Get full text
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Identification of a coronary vascular progenitor cell in the human heart
Published in Proceedings of the National Academy of Sciences - PNAS (15-09-2009)“…Primitive cells capable of generating small resistance arterioles and capillary structures in the injured myocardium have been identified repeatedly. However,…”
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Pulmonary arterial hypertension: the case for a bioelectronic treatment
Published in Bioelectronic medicine (10-12-2019)“…Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology,…”
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Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs
Published in Physiological genomics (14-03-2007)“…1 Department of Physiology, New York Medical College, Valhalla, New York 2 Sector of Medicine, Scuola Superiore Sant' Anna, Pisa, Italy Our aim was to…”
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RETRACTED: Identification of a coronary vascular progenitor cell in the human heart
Published in Proceedings of the National Academy of Sciences - PNAS (15-09-2009)“…Primitive cells capable of generating small resistance arterioles and capillary structures in the injured myocardium have been identified repeatedly. However,…”
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Hemodynamic effects of Enalapril and B‐type natriuretic peptide on the progression of pacing induced cardiac myopathy in conscious dogs
Published in The FASEB journal (01-04-2016)“…Abstract only…”
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Abstract 17013: Voltage Resolution of Standard Bipolar and Omnipolar Ventricular Electrograms
Published in Circulation (New York, N.Y.) (17-11-2020)“…IntroductionStandard bipolar voltage (BiV) mapping is dependent on bipole axis orientation compared to the direction of the activation wavefront. In contrast,…”
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Hyperglycemia induces defective Ca2+ homeostasis in cardiomyocytes
Published in American journal of physiology. Heart and circulatory physiology (01-01-2017)“…Diabetes and other metabolic conditions characterized by elevated blood glucose constitute important risk factors for cardiovascular disease. Hyperglycemia…”
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Notch signaling modulates the electrical behavior of cardiomyocytes
Published in American journal of physiology. Heart and circulatory physiology (01-01-2018)“…Notch receptor signaling is active during cardiac development and silenced in myocytes after birth. Conversely, outward K Kv currents progressively appear in…”
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Intramyocardial VEGF-B 167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy
Published in Circulation research (25-06-2010)“…Rationale : Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is…”
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Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Published in Nature biomedical engineering (01-06-2022)“…Peripheral neurons that sense glucose relay signals of glucose availability to integrative clusters of neurons in the brain. However, the roles of such…”
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Intramyocardial VEGF-B167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated Cardiomyopathy
Published in Circulation research (25-06-2010)“…RATIONALE:Vascular endothelial growth factor (VEGF)-B selectively binds VEGF receptor (VEGFR)-1, a receptor that does not mediate angiogenesis, and is emerging…”
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Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart
Published in American journal of physiology. Heart and circulatory physiology (01-03-2014)“…In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes…”
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Myocyte repolarization modulates myocardial function in aging dogs
Published in American journal of physiology. Heart and circulatory physiology (01-04-2016)“…Studies of myocardial aging are complex and the mechanisms involved in the deterioration of ventricular performance and decreased functional reserve of the old…”
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Acetylation mediates Cx43 reduction caused by electrical stimulation
Published in Journal of molecular and cellular cardiology (01-10-2015)“…Abstract Communication between cardiomyocytes depends upon gap junctions (GJ). Previous studies have demonstrated that electrical stimulation induces GJ…”
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Impact of High‐Fructose Consumption on the Canine Cardiovascular System
Published in The FASEB journal (01-04-2012)“…Abstract only Many studies have shown the correlation between fructose consumption (FC) and detrimental effects on the cardiovascular system. We hypothesized…”
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Abstract 13799: Electrical Pacing Inhibits Gap Junction-Mediated Cardiac Cell -Cell Communication by Promoting Cx43-Acetylation
Published in Circulation (New York, N.Y.) (25-11-2014)“…Abstract only Background: Communication among cardiomyocytes depends upon Gap Junction (GJ) protein expression and conductance. Previous studies demonstrated…”
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Acute vagal stimulation attenuates cardiac metabolic response to β‐adrenergic stress
Published in The Journal of physiology (01-12-2012)“…Key points • Whereas the effects of catecholamines on myocardial metabolism are well characterized, the potential role of the parasympathetic system is…”
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Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure
Published in The Journal of pharmacology and experimental therapeutics (01-04-2007)“…Severe heart failure (HF) is characterized by profound alterations in cardiac metabolic phenotype, with down-regulation of the free fatty acid (FFA) oxidative…”
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