Factors affecting antimicrobial activity of Synechococcus leopoliensis

An antimicrobial agent is produced by the cyanobacterium Synechococcus leopoliensis which was found to be active against the Gram-positive bacterium Staphylococcus aureus. The effects of temperature, pH, incubation period, some media and different nitrogen and carbon sources on both growth and antim...

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Bibliographic Details
Published in:	Microbiological research Vol. 159; no. 4; pp. 395 - 402
Main Authors:	Noaman, Nadia H., Fattah, Abdel, Khaleafa, M., Zaky, Seham H.
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-01-2004 Elsevier Science Ltd
Subjects:	Acetic Acid - metabolism Alanine - metabolism Anti-Bacterial Agents - analysis Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - pharmacology Antibiotic production Arabinose - metabolism Biomass Citric Acid - metabolism Culture Media - chemistry Galactose - metabolism Leucine - metabolism Methionine - metabolism Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Synechococcus Synechococcus - growth & development Synechococcus - metabolism Synechococcus leopoliensis Temperature Antibiotic production Synechococcus
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Summary:	An antimicrobial agent is produced by the cyanobacterium Synechococcus leopoliensis which was found to be active against the Gram-positive bacterium Staphylococcus aureus. The effects of temperature, pH, incubation period, some media and different nitrogen and carbon sources on both growth and antimicrobial activity were investigated. Temperature 35 °C and pH 8 were the best for growth and antimicrobial agent production and 14 and 15 days of incubation were found to be the best for maximum growth and antimicrobial activity, respectively, in the medium BG-11. No antimicrobial activity could be detected by the use of G medium, moderate activity was recorded with Chu 10 medium, while high activity was reported in BG-11 medium. Leucine was the best nitrogen source for antimicrobial activity, while maximum antimicrobial activity was introduced by using the carbon sources, citrate and acetate. Very high antimicrobial activity could be detected by using the carbon source galactose in combination with the nitrogen source alanine or by using arabinose with methionine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0944-5013 1618-0623
DOI:	10.1016/j.micres.2004.09.001