Search Results - "Khaja, Faisal Tarique"
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Structure-function studies reveal ComEA contains an oligomerization domain essential for transformation in gram-positive bacteria
Published in Nature communications (13-12-2022)“…An essential step in bacterial transformation is the uptake of DNA into the periplasm, across the thick peptidoglycan cell wall of Gram-positive bacteria, or…”
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Identification and characterization of Helicobacter pylori O‐acetylserine‐dependent cystathionine β‐synthase, a distinct member of the PLP‐II family
Published in Molecular microbiology (01-08-2019)“…Summary O‐acetylserine sulfhydrylase (OASS) and cystathionine β‐synthase (CBS) are members of the PLP‐II family, and involved in L‐cysteine production. OASS…”
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A mutation in the ribosomal protein uS12 reveals novel functions of its universally conserved PNSA loop
Published in Molecular microbiology (01-06-2021)“…The ribosomal protein uS12 is conserved across all domains of life. Recently, a heterozygous spontaneous mutation in human uS12 (corresponding to R49K mutation…”
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Inhibiting Pyridoxal Kinase of Entamoeba histolytica Is Lethal for This Pathogen
Published in Frontiers in cellular and infection microbiology (16-04-2021)“…Pyridoxal 5'-phosphate (PLP) functions as a cofactor for hundreds of different enzymes that are crucial to the survival of microorganisms. PLP-dependent…”
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Structure-Function Studies of the Bacillus subtilis Ric Proteins Identify the Fe-S Cluster-Ligating Residues and Their Roles in Development and RNA Processing
Published in mBio (17-09-2019)“…In , the RicA (YmcA), RicF (YlbF), and RicT (YaaT) proteins accelerate the phosphorylation of the transcription factor Spo0A, contributing to genetic…”
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Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica
Published in Acta crystallographica. Section D, Biological crystallography. (01-11-2014)“…Inositol polyphosphate 1‐phosphatase from Entamoeba histolytica (EhIPPase) is an Mg2+‐dependent and Li+‐sensitive enzyme that catalyzes the hydrolysis of…”
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Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3′-phosphoadenosine 5′-phosphate and inositol 1,4-bisphosphate
Published in Acta crystallographica. Section D, Biological crystallography. (01-07-2014)“…The enzyme 3′‐phosphoadenosine 5′‐phosphatase‐1 (PAP phosphatase‐1) is a member of the Li+‐sensitive Mg2+‐dependent phosphatase superfamily, or inositol…”
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Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes
Published in Structure (London) (02-05-2024)“…Plants being sessile organisms exhibit unique features in ribosomes, which might aid in rapid gene expression and regulation in response to varying…”
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Characterization and functional insights into the Entamoeba histolytica pyridoxal kinase, an enzyme essential for its survival
Published in Journal of structural biology (01-12-2020)“…[Display omitted] •E. histolytica has only pyridoxal kinase (EhPLK) enzyme of salvage pathway to synthesize pyridoxal 5′-phosphate.•It lacks pyridoxine…”
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Structural insight into β-Clamp and its interaction with DNA Ligase in Helicobacter pylori
Published in Scientific reports (08-08-2016)“…Helicobacter pylori, a gram-negative and microaerophilic bacterium, is the major cause of chronic gastritis, gastric ulcers and gastric cancer. Owing to its…”
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Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain
Published in Archives of biochemistry and biophysics (01-12-2013)“…•Sub-micellar SDS concentration rapidly induces fibrillization of SB at pH 2.0.•Bis-ANS is about 3-fold more potent inhibitor of SB fibrillation than…”
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Structural insight into [beta]-Clamp and its interaction with DNA Ligase in Helicobacter pylori
Published in Scientific reports (01-08-2016)“…Helicobacter pylori, a gram-negative and microaerophilic bacterium, is the major cause of chronic gastritis, gastric ulcers and gastric cancer. Owing to its…”
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