Search Results - "Khairia M. Youssef"

Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3 H)-quinazolinone analogs by Al-Rashood, Sarah T., Aboldahab, Ihsan A., Nagi, Mahmoud N., Abouzeid, Laila A., Abdel-Aziz, Alaa A.M., Abdel-hamide, Sami G., Youssef, Khairia M., Al-Obaid, Abdulrahman M., El-Subbagh, Hussein I.

“…In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure…”
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Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents by Fawzy, Iten M, Youssef, Khairia M, Lasheen, Deena S, Ismail, Nasser SM, Abouzid, Khaled AM

“…Imatinib possesses various mechanisms for combating cancer, making the development of imatinib analogs an attractive target for cancer research. Two series of…”
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Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays by Abdelshaheed, Menna M, El Subbagh, Hussein I, Tantawy, Mohamed A, Attia, Reem T, Youssef, Khairia M, Fawzy, Iten M

“…Pyridine is a nitrogen bearing heterocyclic scaffold that shows a wide range of biological activities. The pyridine nucleus has become an interesting target…”
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Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents by Ghith, Amna, Youssef, Khairia M., Ismail, Nasser S.M., Abouzid, Khaled A.M.

“…[Display omitted] •25 compounds were screened against VEGFR-2 kinase enzyme.•Selected compounds were assessed in vitro against full NCI 60 cell lines.•10a…”
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New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity by El‐Gazzar, Yomna I., Ghaiad, Heba R., El Kerdawy, Ahmed M., George, Riham F., Georgey, Hanan H., Youssef, Khairia M., El‐Subbagh, Hussein I.

“…New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and…”
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PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells by Al-Hujaily, Ensaf M., Mohamed, Ameera Gaafar, Al-Sharif, Ibtehaj, Youssef, Khairia M., Manogaran, Pulicat S., Al-Otaibi, Basem, Al-Haza’a, Amal, Al-Jammaz, Ibrahim, Al-Hussein, Khaled, Aboussekhra, Abdelilah

“…We have investigated here the anti-breast cancer properties of two novel curcumin analogues, EAC and PAC. Apoptosis was assessed by the annexin V/propidium…”
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Newly Designed and Synthesized Curcumin Analogs with in vitro Cytotoxicity and Tubulin Polymerization Activity by Fawzy, Iten M., Youssef, Khairia M., Ismail, Nasser S. M., Gullbo, Joachim, Abouzid, Khaled A. M.

“…Novel curcumin analogs with 4‐piperidone ring were designed, synthesized, and evaluated for their cytotoxic activities against five different cancer cell…”
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Synthesis of Curcumin Analogues as Potential Antioxidant, Cancer Chemopreventive Agents by Youssef, Khairia M., El-Sherbeny, Magda A., El-Shafie, Faiza S., Farag, Hassan A., Al-Deeb, Omar A., Awadalla, Sit Albanat A.

“…New series of 3, 5‐bis(substituted benzylidene)‐4‐piperidones, 2, 7‐bis(substituted benzylidene)cycloheptanones, 1, 5‐bis(substituted phenyl)‐1,…”
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Synthesis and Antitumor Activity of Some Curcumin Analogs by Youssef, Khairia M., El-Sherbeny, Magda A.

“…In this study, four new curcurmin analogs (compounds 1, 2, 17 and 18) were synthesized. 17 [3,5‐bis(4‐hydroxy‐3‐methoxy‐5‐methylcinnamyl)N‐methylpiperidone]…”
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Synthesis and In Vitro Antioxidant Activity of some New Fused Pyridine Analogs by Al-Omar, Mohamed A., Youssef, Khairia M., El-Sherbeny, Magda A., Awadalla, Sit. Albanat A., El-Subbagh, Hussein I.

“…A new series of pyrano[3,2‐c]pyridines, pyrazolo[4,3‐c]pyridines, and pyrido[4,3‐d]pyrimidines were synthesized and screened for their in vitro antioxidant…”
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Design and synthesis of potential ribonucleotide reductase enzyme (RNR) inhibitors as antileukemic and/or antiviral 2′-deoxymethylene nucleosides by Khairia M. Youssef, Eric J. Lien

“…In order to improve the antitumor and/or antiviral activities of existing nucleoside analogs, eight new compounds (9a,b, 14a,b, 15a,b and 16a,b) were designed…”
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Chemopreventive effects of curcumin analogs in DMH-Induced colon cancer in albino rats model by Khairia M. Youssef, Azza M. Ezzo, Moushira I. El-Sayed, Amal A. Hazzaa, Azza H. EL-Medany, Maha Arafa

“…Synthesis and preclinical safety evaluation in mice and rats of Curcumin (1) and curcumin analogs (2, 3) were done. Besides, the chemopreventive effects in…”
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Design, synthesis and biological evaluation of Novel Curcumin Analogs with anticipated anticancer activity by Iten M. Fawzy, Khairia M. Youssef, Nasser S.M. Ismail, J. Gullbo, Khaled A.M. Abouzid

“…Context: Extensive research conducted within past years revealed that curcumin is a highly pleiotropic molecule that interacts with a diverse range of…”
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Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and and breast cancer biological assays by Abdelshaheed, Menna M, El Subbagh, Hussein I, Tantawy, Mohamed A, Attia, Reem T, Youssef, Khairia M, Fawzy, Iten M

“…Pyridine is a nitrogen bearing heterocyclic scaffold that shows a wide range of biological activities. The pyridine nucleus has become an interesting target…”
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QSAR of Novel Hydroxyphenylureas as Antioxidant Agents by Deeb, Omar, Youssef, Khairia M., Hemmateenejad, Bahram

“…A set of descriptors consisting of quantum, chemical, and topological descriptors has been used for modeling the activity of novel hydroxyphenylureas to…”
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Synthesis of curcumin and ethylcurcumin bioconjugates as potential antitumor agents by Al-Wabli, Reem I., AboulWafa, Omaima M., Youssef, Khairia M.

“…Some new curcumin and ethylcurcumin bioconjugates with various functionalities supported on the curcumin skeleton were synthesized and evaluated for antitumor…”
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PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells by Hujaily, Ensaf M. Al, Mohamed, Ameera Gaafar, Sharif, Ibtehaj Al, Youssef, Khairia M, Manogaran, Pulicat S, Otaibi, Basem Al, Hazaa, Amal Al, Jammaz, Ibrahim Al, Hussein, Khaled Al, Aboussekhra, Abdelilah

“…We have investigated here the anti-breast cancer properties of two novel curcumin analogues, EAC and PAC. Apoptosis was assessed by the annexin V/propidium…”
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Synthesis, antiplatelet aggregation activity, and molecular modeling study of novel substituted-piperazine analogues by Youssef, Khairia M., Al-Omar, Mohamed A., El-Subbagh, Hussein I., Abou-zeid, Laila A., Abdel-Gader, Abdel-Galil M., Haress, Nadia G., Al-Tuwaijri, Ali S.

“…New carbamoylpyridine and carbamoylpiperidine analogues containing nipecotic acid scaffold were designed, synthesized, and evaluated for their platelet…”
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N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study by Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh

“…Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were…”
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ANTIPYRETIC, ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF CERTAIN γ-OXOBUTANOIC ACID DERIVATIVES by Abouzid, Khaled A., Youssef, Khairia M., Ahmed, Amany A. E., Hussain Al-Zuhair, Hanaa

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