Search Results - "Khairallah, E A"

Selective Protein Covalent Binding and Target Organ Toxicity by Cohen, Steven D., Pumford, Neil R., Khairallah, Edward A., Boekelheide, Kim, Pohl, Lance R., Amouzadeh, H.R., Hinson, Jack A.

“…Protein covalent binding by xenobiotic metabolites has long been associated with target organ toxicity but mechanistic involvement of such binding has not been…”
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Selective Protein Arylation and Acetaminophen-Induced Hepatotoxicity by Cohen, Steven D., Khairallah, Edward A.

“…More than 20 years have passed since the early reports of acute hepatotoxicity with APAP overdose. During that period investigative research to discover the…”
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Identification of the Mouse Liver 44-kDa Acetaminophen-Binding Protein as a Subunit of Glutamine Synthetase by Bulera, S.J., Birge, R.B., Cohen, S.D., Khairallah, E.A.

“…Identification of proteins that covalently bind acetaminophen (APAP) is essential for a clearer understanding of the hepatotoxicity that results after an APAP…”
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Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase by Landin, Judith S., Cohen, Steven D., Khairallah, Edward A.

“…The covalent binding of acetaminophen (APAP) to mitochondrial proteins has been postulated to alter the function of the organelle and contribute to the…”
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Inhibition of Protein Phosphatase Activity and Changes in Protein Phosphorylation Following Acetaminophen Exposure in Cultured Mouse Hepatocytes by Bruno, M.K., Khairallah, E.A., Cohen, S.D.

“…Protein phosphorylation was determined in cultured mouse hepatocytes exposed to an hepatotoxic concentration of acetaminophen (APAP) for selected times up to…”
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Acetaminophen inhibits NF-κB activation by interfering with the oxidant signal in murine hepa 1-6 cells by HAMID BOULARES, A, GIARDINA, C, INAN, M. S, KHAIRALLAH, E. A, COHEN, S. D

“…A toxic dose of acetaminophen (APAP) reduces the activity of NF- Kappa B in mouse liver. NF- Kappa B inactivation may be important for APAP toxicity, as this…”
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Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen : An inhibition of c-myc expression, NF-κB activation, and Raf-1 kinase activity by BOULARES, H. A, GIARDINA, C, NAVARRO, C. L, KHAIRALLAH, E. A, COHEN, S. D

“…Acetaminophen (APAP) is a widely used analgesic and antipyretic that can lead to severe liver damage when taken at excessive doses. APAP toxicity results when…”
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Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity by Manautou, J E, Hoivik, D J, Tveit, A, Hart, S G, Khairallah, E A, Cohen, S D

“…Peroxisome proliferators have been shown to diminish acetaminophen (APAP) hepatotoxicity (Biochem. Pharmacol. 43, 1395, 1992). To investigate the mechanistic…”
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Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice by Meyers, L L, Beierschmitt, W P, Khairallah, E A, Cohen, S D

“…Morphological changes are observed in mitochondria early in the course of acetaminophen (APAP) hepatotoxicity. In order to determine if functional deficits…”
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Acetaminophen-arylated proteins are detected in hepatic subcellular fractions and numerous extra-hepatic tissues in CD-1 and C57B1/6J mice by Bulera, S.J., Cohenb, S.D., Khairallah, E.A.

“…To identify acetaminophen (APAP)-bound proteins in addition to the major 44 and 58 kDa APAP-binding proteins (Bartolone et al., 1992, Toxicol. Appl. Pharmacol…”
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Sequestration of cytoplasmic enzymes in an autophagic vacuole-lysosomal system induced by injection of leupeptin by Kominami, E, Hashida, S, Khairallah, E A, Katunuma, N

“…Administration of leupeptin to rats induces the accumulation of numerous autophagic vacuoles in the liver. Furuno et al. (Furuno, K., Ishikawa, T., and Kato,…”
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Protection by Clofibrate against Acetaminophen Hepatotoxicity in Male CD-1 Mice Is Associated with an Early Increase in Biliary Concentration of Acetaminophen–Glutathione Adducts by Manautou, José E., Tveit, Ann, Hoivik, Debie J., Khairallah, Edward A., Cohen, Steven D.

“…Repeated treatment with clofibrate (CFB) significantly increased hepatic glutathione (GSH) content and also diminished acetaminophen's (APAP) selective protein…”
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Gender-Related Differences in Susceptibility to Acetaminophen-Induced Protein Arylation and Nephrotoxicity in the CD-1 Mouse by Hoivik, D.J., Manautou, J.E., Tveit, A., Hart, S.G.E., Khairallah, E.A., Cohen, S.D.

“…Acetaminophen (APAP) is a commonly used analgesic and antipyretic agent which, in high doses, causes liver and kidney necrosis in man and animals. Damage in…”
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Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins by Bartolone, J B, Birge, R B, Sparks, K, Cohen, S D, Khairallah, E A

“…A sensitive immunoassay for detecting acetaminophen (APAP) bound to proteins was developed using an affinity purified antibody directed against the…”
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Immunochemical detection of acetaminophen-bound liver proteins by Bartolone, J B, Sparks, K, Cohen, S D, Khairallah, E A

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Selective acetaminophen metabolite binding to hepatic and extrahepatic proteins: an in vivo and in vitro analysis by Bartolone, J B, Beierschmitt, W P, Birge, R B, Hart, S G, Wyand, S, Cohen, S D, Khairallah, E A

“…Acetaminophen (APAP) administration (600 mg/kg, po) to fasted male CD-1 mice resulted in cellular damage to liver, lung, and kidney. An affinity purified…”
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Antidotal effectiveness of N-acetylcysteine in reversing acetaminophen-induced hepatotoxicity. Enhancement of the proteolysis of arylated proteins by Bruno, M K, Cohen, S D, Khairallah, E A

“…The post-arylative mechanisms by which N-acetylcysteine (NAC) reduces the severity of the hepatotoxicity induced by acetaminophen (APAP) were investigated in…”
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Genes encoding the acetaminophen and selenium binding proteins map to mouse chromosome 3 by Navarro, C L, Cohen, S D, Khairallah, E A

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Evidence against deacetylation and for cytochrome P450-mediated activation in acetaminophen-induced nephrotoxicity in the CD-1 mouse by Emeigh Hart, S G, Beierschmitt, W P, Bartolone, J B, Wyand, D S, Khairallah, E A, Cohen, S D

“…Acetaminophen (APAP) administration (600 mg/kg, po) results in proximal tubular necrosis in 18-hr fasted, 3-month-old male CD-1 mice. This study was undertaken…”
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Selective alterations in the patterns of newly synthesized proteins by acetaminophen and its dimethylated analogues in primary cultures of mouse hepatocytes by Bruno, M K, Cohen, S D, Khairallah, E A

“…Alterations in protein synthesis following exposure to and recovery from hepatotoxic doses of acetaminophen (APAP) and its analogues, 3,5-dimethyl…”
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