Search Results - "Khair, Lyne"

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages by Yan, Jinglian, Tie, Guodong, Wang, Shouying, Tutto, Amanda, DeMarco, Natale, Khair, Lyne, Fazzio, Thomas G., Messina, Louis M.

“…People with type 2 diabetes mellitus (T2DM) have a 25-fold higher risk of limb loss than non-diabetics due in large part to impaired wound healing. Here, we…”
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Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells by Tie, Guodong, Yan, Jinglian, Khair, Lyne, Messina, Julia A, Deng, April, Kang, Joonsoo, Fazzio, Thomas, Messina, Louis M

“…Obesity will soon surpass smoking as the most preventable cause of cancer. Hypercholesterolemia, a common comorbidity of obesity, has been shown to increase…”
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Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway by Tie, Guodong, Yan, Jinglian, Khair, Lyne, Tutto, Amanda, Messina, Louis M.

“…Hypercholesterolemia accelerates the phenotypes of aging in hematopoietic stem cells (HSCs). As yet, little is known about the underlying mechanism. We found…”
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Nbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells by Khair, Lyne, Baker, Richard E, Linehan, Erin K, Schrader, Carol E, Stavnezer, Janet

“…Activation-induced cytidine deaminase (AID) is required for initiation of Ig class switch recombination (CSR) and somatic hypermutation (SHM) of antibody genes…”
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Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment by Moser, Bettina A, Subramanian, Lakxmi, Khair, Lyne, Chang, Ya-Ting, Nakamura, Toru M

“…The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts,…”
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The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning by Noguchi, Chiaki, Singh, Tanu, Ziegler, Melissa A, Peake, Jasmine D, Khair, Lyne, Aza, Ana, Nakamura, Toru M, Noguchi, Eishi

“…Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures…”
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Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching by Ucher, Anna J, Ranjit, Sanjay, Kadungure, Tatenda, Linehan, Erin K, Khair, Lyne, Xie, Elaine, Limauro, Jennifer, Rauch, Katherina S, Schrader, Carol E, Stavnezer, Janet

“…Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The AID C terminus…”
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Roles of Heterochromatin and Telomere Proteins in Regulation of Fission Yeast Telomere Recombination and Telomerase Recruitment by Khair, Lyne, Subramanian, Lakxmi, Moser, Bettina A., Nakamura, Toru M.

“…When the telomerase catalytic subunit (Trt1/TERT) is deleted, a majority of fission yeast cells survives by circularizing chromosomes. Alternatively, a small…”
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Repression of Human T-Cell Leukemia Virus Type 1 and Type 2 Replication by a Viral mRNA-Encoded Posttranscriptional Regulator by YOUNIS, Ihab, KHAIR, Lyne, DUNDR, Miroslav, LAIRMORE, Michael D, FRANCHINI, Genoveffa, GREEN, Patrick L

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Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance by Khair, Lyne, Chang, Ya-Ting, Subramanian, Lakxmi, Russell, Paul, Nakamura, Toru M.

“…While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle…”
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Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment by Moser, Bettina A., Subramanian, Lakxmi, Khair, Lyne, Chang, Ya-Ting, Nakamura, Toru M.

“…The checkpoint kinases ATM and ATR are redundantly required for maintenance of stable telomeres in diverse organisms, including budding and fission yeasts,…”
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Abstract 1118: The Effect Of Type 2 Diabetes On Macrophage Differentiation In Non-healing Diabetic Foot Ulcers by Cirka, Haley, Samant, Amruta, Khair, Lyne, Nguyen, Tammy

“…Abstract only Background: Diabetic (DM) patients have a 30-fold increased risk of developing diabetic foot ulcers (DFUs), with 43% of non-healing DFUs…”
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Cul4A and DDB1 Associate with Skp2 To Target p27Kip1 for Proteolysis Involving the COP9 Signalosome by Bondar, Tanya, Kalinina, Anna, Khair, Lyne, Kopanja, Dragana, Nag, Alo, Bagchi, Srilata, Raychaudhuri, Pradip

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1816-LB: Examining the Human Diabetic Bone Marrow Niche by Cirka, Haley, Samant, Amruta, Kostyra, David M, Khair, Lyne, Nguyen, Tammy T

“…Introduction & Objective: Patients with diabetes mellitus (DM) have a 30-fold increased risk of developing diabetes foot ulcers (DFUs), with 43% requiring…”
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Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and gamma delta T Cells from Hematopoietic Stem Cells by Tie, Guodong, Yan, Jinglian, Khair, Lyne, Messina, Julia A, Deng, April, Kang, Joonsoo, Fazzio, Thomas, Messina, Louis M

“…Hypercholesterolemia appears to reduce the lineage priming of hematopoietic stem cells towards innate immune cells, thereby impairing immunosurveillance…”
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Abstract 351: Developing A Human Bone Marrow Organoid Culture System To Study The Diabetic Immune System by Nguyen, Tammy T, Yang Loureiro, Zinger, Desai, Anand, DeSouza, Tiffany, Khair, Lyne, Samant, Amruta, Cirka, Haley, Messina, Louis M, Corvera, Silvia

“…Abstract only Objectives: There is limited understanding on how diabetes negatively impacts wound healing after ischemic tissue damage. Murine models for limb…”
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Abstract 58: Hypercholesterolemia Accelerates the Ageing of Hematopoietic Stem Cells by a Tet1 Dependent Pathway by Tie, Guodong, Yan, Jinglian, Khair, Lyne, Tutto, Amanda, Messina, Louis

“…Abstract only Rationale: Hypercholesterolemia, a major risk factor for cardiovascular disease, also increases all-cause mortality. Previous work from our lab…”
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Abstract 253: Hypercholesterolemia Reduces the Differentiation of Hematopoietic Stem Cells towards Vasculogenic Ly6C low Monocytes in a Tet1 Dependent Pathway by Tie, Guodong, Yan, Jinglian, Khair, Lyne, Tutto, Amanda, Hayes, Kate, Messina, Louis

“…Abstract only Rationale: Hypercholesterolemia has been verified as an important risk factor of cardiovascular diseases. It has been shown to impair the…”
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Abstract 199: Type 2 Diabetes Impairs Wound Healing By DNMT1-dependent Reduction of Hematopoietic Stem Cell Differentiation towards Monocytes/Macrophages and Skewing of the M1/M2 Polarization by Yan, Jinglian, Tie, Guodong, Khair, Lyne, Filippova, Elena, Messina, Louis

“…Abstract only Rationale: People with Type 2 Diabetes Mellitus (T2DM) have a 25x higher risk of limb loss than non-diabetics due in large part to impaired wound…”
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AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C Terminus by Ranjit, Sanjay, Khair, Lyne, Linehan, Erin K., Ucher, Anna J., Chakrabarti, Mrinmay, Schrader, Carol E., Stavnezer, Janet

“…Abstract Activation-induced cytidine deaminase (AID) is induced in B cells during an immune response and is essential for both class-switch recombination (CSR)…”
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