Search Results - "Khachigian, L M"

Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives by Khoo, A, Boyer, M, Jafri, Z, Makeham, T, Pham, T, Khachigian, L M, Floros, P, Dowling, E, Fedder, K, Shonka, Jr, D, Garneau, J, O'Meara, C H

“…Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck squamous cell carcinoma (HNSCC), involves the palatine tonsils, soft palate, base of…”
Get full text

Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection by Billah, M., Ridiandries, A., Rayner, B. S., Allahwala, U. K., Dona, A., Khachigian, L. M., Bhindi, R.

“…Despite improved treatment options myocardial infarction (MI) is still a leading cause of mortality and morbidity worldwide. Remote ischemic preconditioning…”
Get full text

Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression by ZHANG, G, LUO, X, SUMITHRAN, E, PUA, V. S. C, BARNETSON, R. St. C, HALLIDAY, G. M, KHACHIGIAN, L. M

“…Squamous cell carcinoma (SCC) is an invasive malignancy of epidermal keratinocytes. Surgical excision is currently the main treatment; however, this can cause…”
Get full text

Effect of Deoxyribozymes Targeting c-Jun on Solid Tumor Growth and Angiogenesis in Rodents by Zhang, Guishui, Dass, Crispin R., Sumithran, Eric, Di Girolamo, Nick, Sun, Lun-Quan, Khachigian, Levon M.

“…Background: The basic region-leucine zipper protein c-Jun has been linked to cell proliferation, transformation, and apoptosis. However, a direct role for…”
Get full text

EGFR and the complexity of receptor crosstalk in the cardiovascular system by Sanchez-Guerrero, E, Jo, S R, Chong, B H, Khachigian, L M

“…Signaling pathways play a critical role in the maintenance of cellular structure and function. These pathways can act together with synergistic or antagonistic…”
Get more information

Signaling and transcriptional control of Fas ligand gene expression by Kavurma, M M, Khachigian, L M

“…Fas ligand (FasL), a member of the tumor necrosis factor family, initiates apoptosis by binding to its surface receptor Fas. As a consequence, there is…”
Get full text

DNAzymes and cardiovascular disease by Benson, V L, Khachigian, L M, Lowe, H C

“…Gene silencing techniques are gaining increasing popularity in the literature, both as a tool for unravelling gene function and to potentially deliver…”
Get full text

Acute local elevation in monocyte chemoattractant protein-1 (MCP-1), distal to the culprit lesion in acute ST elevation myocardial infarction by Benson, V.L, McMahon, A.C, Khachigian, L.M, Lowe, H.C

Get full text

Effects of MYCN Antisense Oligonucleotide Administration on Tumorigenesis in a Murine Model of Neuroblastoma by Burkhart, Catherine A., Cheng, Andy J., Madafiglio, Janice, Kavallaris, Maria, Mili, Mario, Marshall, Glenn M., Weiss, William A., Khachigian, Levon M., Norris, Murray D., Haber, Michelle

“…Background: Human MYCN (hMYCN) oncogene amplification is a powerful predictor of treatment failure in childhood neuroblastoma, and dysregulation of hMYCN…”
Get full text

Early growth response factor 1 : a pleiotropic mediator of inducible gene expression by KHACHIGIAN, L. M, COLLINS, T

“…The zinc-finger transcription factor, early growth response factor-1 (Egr-1) is an immediate-early gene product inducibly expressed in response to diverse…”
Get full text

Egr-1 is Activated in Endothelial Cells Exposed to Fluid Shear Stress and Interacts With a Novel Shear-Stress-Response Element in the PDGF A-Chain Promoter by Khachigian, Levon M, Anderson, Keith R, Halnon, Nancy J, Gimbrone, Michael A, Resnick, Nitzan, Collins, Tucker

“…Exposure of vascular endothelial cells to fluid mechanical forces can modulate the expression of many genes involved in vascular physiology and…”
Get full text

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury by Khachigian, Levon M., Lindner, Volkhard, Williams, Amy J., Collins, Tucker

“…A number of pathophysiologically relevant genes, including platelet-derived growth factor B-chain (PDGF-B), are induced in the vasculature after acute…”
Get full text

Inducible Expression of Egr-1-Dependent Genes: A Paradigm of Transcriptional Activation in Vascular Endothelium by Khachigian, Levon M, Collins, Tucker

Get full text

A novel model of in-stent restenosis: rat aortic stenting by Lowe, H C, James, B, Khachigian, L M

“…[...]that while the absolute area of ISR formation is modest, the N/M ratio is robust, and significant enough to provide a baseline for the evaluation of…”
Get full text

Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3 by Silverman, E S, Khachigian, L M, Lindner, V, Williams, A J, Collins, T

“…Platelet-derived growth factor (PDGF) A-chain is expressed by vascular smooth muscle cells (SMC) in a variety of pathological settings. Phorbol 12-myristate…”
Get full text

Vessel wall apoptosis and atherosclerotic plaque instability by KAVURMA, M. M., BHINDI, R., LOWE, H. C., CHESTERMAN, C., KHACHIGIAN, L. M.

“…Atherosclerotic cardiovascular disease remains the leading cause of death in the industrialized world. Most cardiovascular deaths result from acute coronary…”
Get full text

N-acetyl cysteine blocks mesangial VCAM-1 and NF-kappa B expression in vivo by Khachigian, LM, Collins, T, Fries, JW

“…Inducible vascular cell adhesion molecule-1 (VCAM-1) in glomerular mesangial cells (GMC) exposed to lipopolysaccharide (LPS) in vitro involves the activation…”
Get full text

Early Growth Response Factor-1 Induction by Injury Is Triggered by Release and Paracrine Activation by Fibroblast Growth Factor-2 by Santiago, Fernando S., Lowe, Harry C., Day, Fiona L., Chesterman, Colin N., Khachigian, Levon M.

“…Cell migration and proliferation that follows injury to the artery wall is preceded by signaling and transcriptional events that converge at the promoters of…”
Get full text

GC Factor 2 Represses Platelet-Derived Growth Factor A-Chain Gene Transcription and Is Itself Induced by Arterial Injury by Khachigian, Levon M, Santiago, Fernando S, Rafty, Louise A, Chan, Onza L.-W, Delbridge, Gabrielle J, Bobik, Alex, Collins, Tucker, Johnson, Alfred C

“…Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for a wide variety of cell types. The genes encoding PDGF A chain (PDGF-A) and PDGF B…”
Get full text

In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1+/CD31+ side‐population cells) by LIANG, S. X., KHACHIGIAN, L. M., AHMADI, Z., YANG, M., LIU, S., CHONG, B. H.

“…To cite this article: Liang SX, Khachigian LM, Ahmadi Z, Yang M, Liu S, Chong BH. In vitro and in vivo proliferation, differentiation and migration of cardiac…”
Get full text