The effect of carnosine on the activity of Na,K,ATPase: prospective uses in clinical cardiology

The effects of carnosine on erythrocyte membrane Na,K-ATPase and isolated enzyme in vitro as well as on membrane Na,K-ATPase activity and lipid peroxidation (LPO) in chronic heart failure (CHF) and acute myocardial infarction (AMI) have been studied. CHF and AMI have been shown to be associated with...

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Bibliographic Details
Published in:	Biokhimiia (Moscow, Russia) Vol. 57; no. 9; p. 1343
Main Authors:	Snimoniia, G V, Tatishvili, N I, Shiliia, D Sh, Bakanidze, N T, Khachidze, M V
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1992
Subjects:	Adult Carnosine - pharmacology Carnosine - therapeutic use Erythrocyte Membrane - drug effects Erythrocyte Membrane - enzymology Female Heart Failure - drug therapy Heart Failure - enzymology Humans Lipid Peroxidation Male Middle Aged Myocardial Infarction - drug therapy Myocardial Infarction - enzymology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - blood
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Summary:	The effects of carnosine on erythrocyte membrane Na,K-ATPase and isolated enzyme in vitro as well as on membrane Na,K-ATPase activity and lipid peroxidation (LPO) in chronic heart failure (CHF) and acute myocardial infarction (AMI) have been studied. CHF and AMI have been shown to be associated with significant inhibition of the erythrocyte membrane Na,K-ATPase activity and LPO activation. Marked activation of erythrocyte membrane Na,K-ATPase by carnosine in comparison with the isolated enzyme has been established. The ability of carnosine to induce Na,K-ATPase activation and prevent membrane depolarization indicates that the dipeptide may be a useful tool in the pathogenetic therapy of CFH and AMI.
ISSN:	0320-9725