Search Results - "Kha, Hue"

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models by Hughes, Paul E, Rex, Karen, Caenepeel, Sean, Yang, Yajing, Zhang, Yihong, Broome, Martin A, Kha, Hue T, Burgess, Teresa L, Amore, Benny, Kaplan-Lefko, Paula J, Moriguchi, Jodi, Werner, Jonathan, Damore, Michael A, Baker, Daniel, Choquette, Deborah M, Harmange, Jean-Christophe, Radinsky, Robert, Kendall, Richard, Dussault, Isabelle, Coxon, Angela

“…The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of…”
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Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth by Carnahan, Josette, Beltran, Pedro J, Babij, Carol, Le, Quynh, Rose, Mark J, Vonderfecht, Steven, Kim, Joseph L, Smith, Adrian L, Nagapudi, Karthik, Broome, Martin A, Fernando, Manory, Kha, Hue, Belmontes, Brian, Radinsky, Robert, Kendall, Richard, Burgess, Teresa L

“…Raf inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent activating mutations in B-Raf. Here, we show that…”
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Preferential Maintenance of Critically Short Telomeres in Mammalian Cells Heterozygous for mTert by Liu, Yie, Kha, Hue, Ungrin, Mark, Robinson, Murray O., Harrington, Lea

“…Prolonged growth of murine embryonic stem (ES) cells lacking the telomerase reverse transcriptase, mTert, results in a loss of telomere DNA and an increased…”
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Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation by Gluzman-Poltorak, Zoya, Mendonca, Sarita R, Vainstein, Vladimir, Kha, Hue, Basile, Lena A

“…The hematopoietic syndrome of the acute radiation syndrome (HSARS) is a life-threatening condition in humans exposed to total body irradiation (TBI); no drugs…”
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Recombinant Human IL-12 Exerts Differential Effects on Circulating CD56bright and CD56dim NK Cells in Healthy Human Subjects by Thomas, Simmy, Lawrence, Chris E, Mar, Vernon, Kha, Hue, Basile, Lena A

“…Interleukin-12 (IL-12) has potent immunoregulatory and hematopoietic properties, and exerts significant biological effects on natural killer (NK) cells,…”
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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation by Vassar, Robert, Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Yan, Qiao, Richards, William G, Citron, Martin

“…Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear normal in gross anatomy, tissue histology, hematology and clinical…”
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Recombinant Human IL-12 Promotes NK Cell Migration: Increased CXCL10, Co-Receptors IL-12Rβ2 and CXCR3, and Bright CD56 NK Cells In Healthy Human Subjects by Thomas, Simmy, Lawrence, Chris E., Mar, Vernon, Kha, Hue, Vainstein, Vladimir, Gokhale, Mamata, Basile, Lena A.

“…Interleukin-12 (IL-12) is a heterodimeric cytokine with pleiotropic effects as a potent immunoregulatory molecule and a hematopoietic stimulatory factor…”
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A Single-Arm PHASE 2A Study of NM-IL-12 (rHu-IL12) in Patients with Mycosis Fungoides-Type CTCL (MF) Undergoing Low-Dose TOTAL Skin Electron BEAM Therapy (LD-TSEBT) by Kim, Youn H, Hoppe, Richard T., Rook, Alain H, Maity, Amit, Geskin, Larisa J, Horowitz, David P, Finnegan, Genet, Khodadoust, Michael, Weng, Wen-Kai, Lares, Analuisa, Hong, Eric Ki Jun, Buchanan, Marie, Ma, Vernon, Kha, Hue, Lawrence, Chris E, Vainstein, Vladimir, Basile, Lena A

“…Multiple treatment modalities are available for MF, but most result in inevitable relapse. Therefore, new treatment strategies that improve response rate and…”
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Abstract 3558: In vitro and in vivo profiling of class I and class II ATP-competitive c-Met kinase inhibitors defines potential c-Met-specific sensitivity biomarkers by Kaplan-Lefko, Paula, Rex, Karen, Zhang, Yihong, Yang, Yajing, Kha, Hue, Ziegler, Beth, Moriguchi, Jodi, Mallari, Mel, Zhao, Xiaoning, Choquette, Deborah, Lewis, Richard, Lin, Jasmine, Shimanovich, Roman, Broome, Martin, Dussault, Isabelle

“…Abstract c-Met is a receptor tyrosine kinase with oncogenic potential for which several small molecule inhibitors are currently being tested in clinical…”
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Abstract 21: Selective and potent inhibitors of the mutant B-Raf pathway paradoxically stimulate the MAPK pathway in wild-type B-Raf cells by Carnahan, Josette, Beltran, Pedro, Babij, Carol, Le, Quynh, Rose, Mark J., Vonderfecht, Steven, Kim, Joseph L., Smith, Adrian L., Broome, Martin A., Fernando, Manory, Kha, Hue, Belmontes, Brian, Radinsky, Robert, Kendall, Richard, Burgess, Teresa L.

“…Abstract B-Raf is a member of the Raf family of serine/threonine kinases, which also include A-Raf and C-Raf. While all 3 Raf kinases stimulate the MAPK…”
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A telomerase enzymatic assay that does not use polymerase chain reaction, radioactivity, or electrophoresis by Kha, Hue, Zhou, Wen, Chen, Kui, Karan-Tamir, Barbara, San Miguel, Tisha, Zeni, Lisa, Kearns, Karen, Mladenovic, Alex, Rasnow, Brian, Robinson, Murray, Wahl, Robert C.

“…A telomerase assay has been developed for high-throughput screening in 96-well microtiter plates. A crude cell lysate which adds telomere repeats to a…”
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Mice deficient in BACE1, the Alzheimer's b-secretase, have normal phenotype and abolished b-amyloid generation by Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Yan, Qiao, Richards, William G, Citron, Martin, Vassar, Robert

“…Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear normal in gross anatomy, tissue histology, hematology and clinical…”
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Mice deficient in BACE1, the Alzheimer's [beta]-secretase, have normal phenotype and abolished [beta]-amyloid generation by Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Qiao, Yan, Richards, William G, Citron, Martin, Vassar, Robert

“…Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear normal in gross anatomy, tissue histology, hematology and clinical…”
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An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist by YU, Y.-L, KHA, H, GOLDEN, J. A, MIGCHIELSEN, A. A. J, GOETZL, E. J, TURCK, C. W

“…Polymerase chain reaction amplification of cDNA for acidic fibroblast growth factor in several lines of cultured human cells revealed two forms of mRNA. The…”
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