Search Results - "Keys, Timothy G."

Cytoplasmic glycoengineering enables biosynthesis of nanoscale glycoprotein assemblies by Tytgat, Hanne L. P., Lin, Chia-wei, Levasseur, Mikail D., Tomek, Markus B., Rutschmann, Christoph, Mock, Jacqueline, Liebscher, Nora, Terasaka, Naohiro, Azuma, Yusuke, Wetter, Michael, Bachmann, Martin F., Hilvert, Donald, Aebi, Markus, Keys, Timothy G.

“…Glycosylation of proteins profoundly impacts their physical and biological properties. Yet our ability to engineer novel glycoprotein structures remains…”
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Bacterial genome-wide association study substantiates papGII of Escherichia coli as a major risk factor for urosepsis by Cuénod, Aline, Agnetti, Jessica, Seth-Smith, Helena M. B., Roloff, Tim, Wälchli, Denise, Shcherbakov, Dimitri, Akbergenov, Rashid, Tschudin-Sutter, Sarah, Bassetti, Stefano, Siegemund, Martin, Nickel, Christian H., Moran-Gilad, Jacob, Keys, Timothy G., Pflüger, Valentin, Thomson, Nicholas R., Egli, Adrian

“…Abstract Background Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, often caused by uropathogenic Escherichia coli …”
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Engineering the product profile of a polysialyltransferase by Keys, Timothy G, Fuchs, Hazel L S, Ehrit, Jörg, Alves, Jürgen, Freiberger, Friedrich, Gerardy-Schahn, Rita

“…Functional assessments and applications of polysaccharides are hampered by broad product distributions. Neutral drift libraries now identify specific amino…”
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A universal fluorescent acceptor for high-performance liquid chromatography analysis of pro- and eukaryotic polysialyltransferases by Keys, Timothy G., Freiberger, Friedrich, Ehrit, Jörg, Krueger, Jonas, Eggers, Katinka, Buettner, Falk F.R., Gerardy-Schahn, Rita

“…Polysialyltransferases (polySTs) play critical roles in diverse biological processes, including neural development, tumorigenesis, and bacterial pathogenesis…”
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Surface Cross-Linking by Macromolecular Tethers Enhances Virus-like Particles’ Resilience to Mucosal Stress Factors by Ali, Ahmed, Ganguillet, Suwannee, Turgay, Yagmur, Keys, Timothy G., Causa, Erika, Fradique, Ricardo, Lutz-Bueno, Viviane, Chesnov, Serge, Tan-Lin, Chia-Wei, Lentsch, Verena, Kotar, Jurij, Cicuta, Pietro, Mezzenga, Raffaele, Slack, Emma, Radiom, Milad

“…Virus-like particles (VLPs) are emerging as nanoscaffolds in a variety of biomedical applications including delivery of vaccine antigens and cargo such as mRNA…”
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Biosynthesis of Glycoconjugate Virus-like Particles (VLPs) by Oi, Kathryn K, Kloter, Tom A, Keys, Timothy G

“…The outermost surface of bacterial pathogens consists primarily of complex carbohydrate structures-polysaccharides, glycolipids, and glycoproteins. To raise a…”
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A biosynthetic route for polysialylating proteins in Escherichia coli by Keys, Timothy G., Wetter, Michael, Hang, Ivan, Rutschmann, Christoph, Russo, Simona, Mally, Manuela, Steffen, Michael, Zuppiger, Matthias, Müller, Fabian, Schneider, Jörg, Faridmoayer, Amirreza, Lin, Chia-wei, Aebi, Markus

“…Polysialic acid (polySia) is a posttranslational modification found on only a handful of proteins in the central nervous and immune systems. The addition of…”
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Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen by Ehrit, Jörg, Keys, Timothy G., Sutherland, Mark, Wolf, Saskia, Meier, Chris, Falconer, Robert A., Gerardy‐Schahn, Rita

“…α2,8‐Linked polysialic acid (polySia) is an oncofoetal antigen with high abundance during embryonic development. It reappears in malignant tumours of…”
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A high-throughput screen for polysialyltransferase activity by Keys, Timothy G., Berger, Monika, Gerardy-Schahn, Rita

“…Polysialic acid is common to humans and a few bacterial pathogens and it holds great potential for the development of new therapeutic reagents. Currently, the…”
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Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases from Neisseria meningitidis W and Y Defines a New Sialyltransferase Family by Romanow, Angela, Keys, Timothy G., Stummeyer, Katharina, Freiberger, Friedrich, Henrissat, Bernard, Gerardy-Schahn, Rita

“…Crucial virulence determinants of disease causing Neisseria meningitidis species are their extracellular polysaccharide capsules. In the serogroups W and Y,…”
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A single amino acid toggles Escherichia coli polysialyltransferases between mono- and bifunctionality by Keys, Timothy G, Fuchs, Hazel L S, Galuska, Sebastian P, Gerardy-Schahn, Rita, Freiberger, Friedrich

“…The enteropathogenic Escherichia coli K92 synthesizes a unique capsule consisting of polysialic acid (polySia) with alternating α2,8- and α2,9-linkages. The…”
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Screening a natural product-based combinatorial library using FTICR mass spectrometry by Poulsen, Sally-Ann, Davis, Rohan A., Keys, Timothy G.

“…FTICR mass spectrometry was utilised to screen a natural product-based combinatorial library for bovine carbonic anhydrase II binders. One high-affinity ligand…”
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Think small – Methoden zur in vitro-Evolution von Polymerasen by Keys, Timothy G., Gerardy-Schahn, Rita

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Engineering protein glycosylation in prokaryotes by Keys, Timothy G., Aebi, Markus

“…Controlling the specific glycan structure(s) present on a glycoprotein is a key challenge for both understanding its function and for developing effective next…”
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