Search Results - "Keys, Kevin L."

On the cross-population generalizability of gene expression prediction models by Keys, Kevin L, Mak, Angel C Y, White, Marquitta J, Eckalbar, Walter L, Dahl, Andrew W, Mefford, Joel, Mikhaylova, Anna V, Contreras, María G, Elhawary, Jennifer R, Eng, Celeste, Hu, Donglei, Huntsman, Scott, Oh, Sam S, Salazar, Sandra, Lenoir, Michael A, Ye, Jimmie C, Thornton, Timothy A, Zaitlen, Noah, Burchard, Esteban G, Gignoux, Christopher R

“…The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have…”
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Influence of pathway topology and functional class on the molecular evolution of human metabolic genes by Montanucci, Ludovica, Laayouni, Hafid, Dobon, Begoña, Keys, Kevin L, Bertranpetit, Jaume, Peretó, Juli

“…Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome…”
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A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth by Jiang, Yale, Forno, Erick, Han, Yueh-Ying, Xu, Zhongli, Hu, Donglei, Boutaoui, Nadia, Eng, Celeste, Acosta-Pérez, Edna, Huntsman, Scott, Colón-Semidey, Angel, Keys, Kevin L., Rodríguez-Santana, José R., Alvarez, María, Pino-Yanes, Maria, Canino, Glorisa, Chen, Wei, Burchard, Esteban G., Celedón, Juan C.

“…Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two…”
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Ten Simple Rules for Getting Help from Online Scientific Communities by Dall'Olio, Giovanni M, Marino, Jacopo, Schubert, Michael, Keys, Kevin L, Stefan, Melanie I, Gillespie, Colin S, Poulain, Pierre, Shameer, Khader, Sugar, Robert, Invergo, Brandon M, Jensen, Lars J, Bertranpetit, Jaume, Laayouni, Hafid

“…n.a…”
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Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture by Kachuri, Linda, Mak, Angel C. Y., Hu, Donglei, Eng, Celeste, Huntsman, Scott, Elhawary, Jennifer R., Gupta, Namrata, Gabriel, Stacey, Xiao, Shujie, Keys, Kevin L., Oni-Orisan, Akinyemi, Rodríguez-Santana, José R., LeNoir, Michael A., Borrell, Luisa N., Zaitlen, Noah A., Williams, L. Keoki, Gignoux, Christopher R., Burchard, Esteban González, Ziv, Elad

“…We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from 2,733…”
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Sequencing and imputation in GWAS: Cost‐effective strategies to increase power and genomic coverage across diverse populations by Quick, Corbin, Anugu, Pramod, Musani, Solomon, Weiss, Scott T., Burchard, Esteban G., White, Marquitta J., Keys, Kevin L., Cucca, Francesco, Sidore, Carlo, Boehnke, Michael, Fuchsberger, Christian

“…A key aim for current genome‐wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare…”
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Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma by Mak, Angel C Y, White, Marquitta J, Eckalbar, Walter L, Szpiech, Zachary A, Oh, Sam S, Pino-Yanes, Maria, Hu, Donglei, Goddard, Pagé, Huntsman, Scott, Galanter, Joshua, Wu, Ann Chen, Himes, Blanca E, Germer, Soren, Vogel, Julia M, Bunting, Karen L, Eng, Celeste, Salazar, Sandra, Keys, Kevin L, Liberto, Jennifer, Nuckton, Thomas J, Nguyen, Thomas A, Torgerson, Dara G, Kwok, Pui-Yan, Levin, Albert M, Celedón, Juan C, Forno, Erick, Hakonarson, Hakon, Sleiman, Patrick M, Dahlin, Amber, Tantisira, Kelan G, Weiss, Scott T, Serebrisky, Denise, Brigino-Buenaventura, Emerita, Farber, Harold J, Meade, Kelley, Lenoir, Michael A, Avila, Pedro C, Sen, Saunak, Thyne, Shannon M, Rodriguez-Cintron, William, Winkler, Cheryl A, Moreno-Estrada, Andrés, Sandoval, Karla, Rodriguez-Santana, Jose R, Kumar, Rajesh, Williams, L Keoki, Ahituv, Nadav, Ziv, Elad, Seibold, Max A, Darnell, Robert B, Zaitlen, Noah, Hernandez, Ryan D, Burchard, Esteban G

“…Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug…”
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Iterative hard thresholding for model selection in genome‐wide association studies by Keys, Kevin L., Chen, Gary K., Lange, Kenneth

“…ABSTRACT A genome‐wide association study (GWAS) correlates marker and trait variation in a study sample. Each subject is genotyped at a multitude of SNPs…”
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OpenMendel: a cooperative programming project for statistical genetics by Zhou, Hua, Sinsheimer, Janet S., Bates, Douglas M., Chu, Benjamin B., German, Christopher A., Ji, Sarah S., Keys, Kevin L., Kim, Juhyun, Ko, Seyoon, Mosher, Gordon D., Papp, Jeanette C., Sobel, Eric M., Zhai, Jing, Zhou, Jin J., Lange, Kenneth

“…Statistical methods for genome-wide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make…”
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Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth by Lee, Eunice Y, Mak, Angel C Y, Hu, Donglei, Sajuthi, Satria, White, Marquitta J, Keys, Kevin L, Eckalbar, Walter, Bonser, Luke, Huntsman, Scott, Urbanek, Cydney, Eng, Celeste, Jain, Deepti, Abecasis, Gonçalo, Kang, Hyun M, Germer, Soren, Zody, Michael C, Nickerson, Deborah A, Erle, David, Ziv, Elad, Rodriguez-Santana, Jose, Seibold, Max A, Burchard, Esteban G

“…Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain. In this study, we sought to…”
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Ambient air pollution, asthma drug response, and telomere length in African American youth by Lee, Eunice Y., Oh, Sam S., White, Marquitta J., Eng, Celeste S., Elhawary, Jennifer R., Borrell, Luisa N., Nuckton, Thomas J., Zeiger, Andrew M., Keys, Kevin L., Mak, Angel C.Y., Hu, Donglei, Huntsman, Scott, Contreras, Maria G., Samedy, Lesly-Anne, Goddard, Pagé C., Salazar, Sandra L., Brigino-Buenaventura, Emerita N., Davis, Adam, Meade, Kelley E., LeNoir, Michael A., Lurmann, Fred W., Burchard, Esteban G., Eisen, Ellen A., Balmes, John R.

“…Telomere length (TL) can serve as a potential biomarker for conditions associated with chronic oxidative stress and inflammation, such as asthma. Air pollution…”
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Genome‐wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations by Herrera‐Luis, Esther, Espuela‐Ortiz, Antonio, Lorenzo‐Diaz, Fabian, Keys, Kevin L., Mak, Angel C. Y., Eng, Celeste, Huntsman, Scott, Villar, Jesús, Rodriguez‐Santana, Jose R., Burchard, Esteban G., Pino‐Yanes, Maria, Genuneit, Jon

“…Background Severe asthma exacerbations are a major cause of asthma morbidity and increased healthcare costs. Several studies have shown racial and ethnic…”
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BioSimulator.jl: Stochastic simulation in Julia by Landeros, Alfonso, Stutz, Timothy, Keys, Kevin L., Alekseyenko, Alexander, Sinsheimer, Janet S., Lange, Kenneth, Sehl, Mary E.

“…•This work highlights BioSimulator.jl, an open-source master equation simulation engine implemented in the Julia language.•We highlight the comparative…”
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Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT Ligand KITLG/SCF and Gene-By-Air-Pollution Interaction by Mak, Angel C Y, Sajuthi, Satria, Joo, Jaehyun, Xiao, Shujie, Sleiman, Patrick M, White, Marquitta J, Lee, Eunice Y, Saef, Benjamin, Hu, Donglei, Gui, Hongsheng, Keys, Kevin L, Lurmann, Fred, Jain, Deepti, Abecasis, Gonçalo, Kang, Hyun Min, Nickerson, Deborah A, Germer, Soren, Zody, Michael C, Winterkorn, Lara, Reeves, Catherine, Huntsman, Scott, Eng, Celeste, Salazar, Sandra, Oh, Sam S, Gilliland, Frank D, Chen, Zhanghua, Kumar, Rajesh, Martínez, Fernando D, Wu, Ann Chen, Ziv, Elad, Hakonarson, Hakon, Himes, Blanca E, Williams, L Keoki, Seibold, Max A, Burchard, Esteban G

“…Abstract Baseline lung function is a standard diagnostic criterion used by clinicians to detect lung diseases. It is a complex trait significantly influenced…”
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Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function by Goddard, Pagé C., Keys, Kevin L., Mak, Angel C. Y., Lee, Eunice Y., Liu, Amy K., Samedy‐Bates, Lesly‐Anne, Risse‐Adams, Oona, Contreras, María G., Elhawary, Jennifer R., Hu, Donglei, Huntsman, Scott, Oh, Sam S., Salazar, Sandra, Eng, Celeste, Himes, Blanca E., White, Marquitta J., Burchard, Esteban G.

“…Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma…”
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Epigenome-wide association study of lung function in Latino children and youth with asthma by Herrera-Luis, Esther, Li, Annie, Mak, Angel C Y, Perez-Garcia, Javier, Elhawary, Jennifer R, Oh, Sam S, Hu, Donglei, Eng, Celeste, Keys, Kevin L, Huntsman, Scott, Beckman, Kenneth B, Borrell, Luisa N, Rodriguez-Santana, Jose, Burchard, Esteban G, Pino-Yanes, Maria

“…DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been…”
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Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity by Chu, Benjamin B, Keys, Kevin L, German, Christopher A, Zhou, Hua, Zhou, Jin J, Sobel, Eric M, Sinsheimer, Janet S, Lange, Kenneth

“…Abstract Background Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex…”
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Genetic Determinants of Telomere Length in African American Youth by Zeiger, Andrew M., White, Marquitta J., Eng, Celeste, Oh, Sam S., Witonsky, Jonathan, Goddard, Pagé C., Contreras, Maria G., Elhawary, Jennifer R., Hu, Donglei, Mak, Angel C. Y., Lee, Eunice Y., Keys, Kevin L., Samedy, Lesly-Anne, Risse-Adams, Oona, Magaña, Joaquín, Huntsman, Scott, Salazar, Sandra, Davis, Adam, Meade, Kelley, Brigino-Buenaventura, Emerita, LeNoir, Michael A., Farber, Harold J., Bibbins-Domingo, Kirsten, Borrell, Luisa N., Burchard, Esteban G.

“…Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in…”
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Ten Simple Rules for Getting Help from Online Scientific Communities: e1002202 by Marino, Jacopo, Schubert, Michael, Keys, Kevin L, Stefan, Melanie I, Gillespie, Colin S, Poulain, Pierre, Shameer, Khader, Sugar, Robert, Invergo, Brandon M, Jensen, Lars J, Bertranpetit, Jaume, Laayouni, Hafid

“…[...]asking a question in a public website is a good thing. [...]it is a great way to learn faster, and to enter into contact with people from different…”
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The proximal distance algorithm by Lange, Kenneth, Keys, Kevin L

“…In Proceedings of the 2014 International Congress of Mathematicians. Seoul: Kyung Moon, 4:95-116 The MM principle is a device for creating optimization…”
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