Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study

The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m ) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrat...

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Bibliographic Details
Published in:	Nutrients Vol. 13; no. 3; p. 749
Main Authors:	McKenzie, Amy L, Athinarayanan, Shaminie J, McCue, Jackson J, Adams, Rebecca N, Keyes, Monica, McCarter, James P, Volek, Jeff S, Phinney, Stephen D, Hallberg, Sarah J
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26-02-2021 MDPI
Subjects:	3-Hydroxybutyric Acid - blood Adult Aged Biomarkers Blood glucose Blood Glucose - metabolism Blood pressure Carbohydrates Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - prevention & control Diet, Carbohydrate-Restricted - methods Disease prevention Education Fatty liver Fatty Liver - epidemiology Fatty Liver - etiology Fatty Liver - prevention & control Female Glycated Hemoglobin - metabolism Humans Hyperglycemia Hyperglycemia - blood Hyperglycemia - complications Hyperglycemia - diet therapy Hypertension Intervention Longitudinal Studies low carbohydrate Male Medical laboratories Medicare Metabolic disorders Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - diet therapy Metabolic Syndrome - etiology Metformin Middle Aged Nutrition Nutrition therapy obesity Obesity - epidemiology Obesity - etiology Obesity - prevention & control Oils & fats Onsite Patient Education as Topic Pilot Projects prediabetes Prediabetic State - blood Prediabetic State - complications Prediabetic State - diet therapy Prevalence Prevention Prospective Studies Reimbursement remote continuous care Retention Steatosis Telemedicine - methods Treatment Outcome Weight control Young Adult United States > US prediabetes remote continuous care low carbohydrate, metabolic syndrome, obesity
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Summary:	The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m ) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in a single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 of 96 participants). Fifty-one percent of participants (49 of 96) met carbohydrate restriction goals as assessed by blood beta-hydroxybutyrate concentrations for more than one-third of reported measurements. Estimated cumulative incidence of normoglycemia (HbA1c <5.7% without medication) and type 2 diabetes (HbA1c ≥6.5% or <6.5% with medication other than metformin) at two years were 52.3% and 3%, respectively. Prevalence of metabolic syndrome, class II or greater obesity, and suspected hepatic steatosis significantly decreased at two years. These results demonstrate the potential utility of an alternate approach to type 2 diabetes prevention, carbohydrate restricted nutrition therapy delivered through a continuous remote care model, for normalization of glycemia and improvement in related comorbidities.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu13030749