Relationship of depth of invasion to survival outcomes and patterns of recurrence for T3 oral tongue squamous cell carcinoma

Relationship of depth of invasion to survival outcomes and patterns of recurrence for T3 oral tongue squamous cell carcinoma

•DOI is an independent predictor of poor survival outcomes in pT3N0M0 OTSCC patients.•Based on DOI, two prognostic groups may exist within the 8th Ed AJCC pT3N0M0 stage.•DOI (10–20 mm) has worse overall and disease-specific survival than DOI (≤10 mm).•DOI (10–20 mm) had more regional recurrence, esp...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology Vol. 116; p. 105195
Main Authors: Newman, M., Dziegielewski, P.T., Nguyen, N.T.A., Seikaly, H.S., Xie, M., O'Connell, D.A., Harris, J.R., Biron, V.L., Gupta, M.K., Archibald, S.D., Jackson, B.S., Young, J.E.M., Keyes, K.J., Nichols, D.S., Zhang, H.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-05-2021
Subjects:
Adjuvant therapy
Adult
Depth of invasion
Disease specific survival
Humans
Middle Aged
Neoplasm Invasiveness
Oral tongue cancer
Overall survival
Retrospective Studies
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Survival Rate
T3 OTSCC
Tongue Neoplasms - surgery
Squamous cell carcinoma
RT
CSS
Oral tongue cancer
CRT
OS
OCSCC
CCI
PNI
Adjuvant therapy
OTSCC
T3 OTSCC
Depth of invasion
AJCC
Overall survival
HNC
Disease specific survival
LVI
DOI
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•DOI is an independent predictor of poor survival outcomes in pT3N0M0 OTSCC patients.•Based on DOI, two prognostic groups may exist within the 8th Ed AJCC pT3N0M0 stage.•DOI (10–20 mm) has worse overall and disease-specific survival than DOI (≤10 mm).•DOI (10–20 mm) had more regional recurrence, especially in the contralateral neck. Current research is elucidating how the addition of depth of invasion (DOI) to the 8th edition of the American Joint Committee on Cancer (AJCC) TNM staging for oral cavity squamous cell carcinoma influences its prognostic accuracy. However, there is limited research on survival in pT3N0M0 oral tongue SCC (OTSCC) patients when stratifying by DOI. Determine 5-year overall survival (OS), and cancer-specific survival (CSS) for patients with pT3N0M0 oral OTSCC based on shallow DOI (<10 mm) and deep DOI (10–20 mm). Retrospective review involving three tertiary care cancer centers in North America. cT3N0M0 OTSCC patients receiving primary surgical treatment from 2004 to 2018 were identified. Inclusion: age > 18 years old and confirmation of pT3N0M0 OTSCC on surgical pathology. Exclusion: patients undergoing palliative treatment or previous head and neck surgery/radiotherapy. Analysis comprised two groups: shallow pT3 (tumor diameter > 4 cm, DOI < 10 mm) and deep pT3 (DOI 10 mm-20 mm). One hundred and four patients with pT3N0M0 OTSCC were included. Mean age was 59.1 years (range: 18–80.74). Age, gender, and Charlson Comorbidity Index were similar between the two groups (p > 0.05). Recurrence, LVI, PNI, and positive margins were more common in deep T3 tumors (P < 0.05). 5-year OS (50% vs 26%, p = 0.006) and CSS (72% vs 24%, p = 0.005) were worse in deep pT3 tumors. Deep pT3 disease was an independent predictor of OS (p = 0.004) and CSS (p = 0.01) on Cox-Regression analysis. DOI is an independent predictor of poor survival in pT3N0M0 OTSCC patients. Consideration should be given to escalating adjuvant therapy for deep pT3N0M0 OTSCC patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2021.105195