Search Results - "Keyel, Peter A"

How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1 by Keyel, Peter A.

“…•IL-1β, IL-18 and HMGB1 are secreted by inflammasomes in response to threats.•IL-1β, IL-18 and HMGB1 are detrimental in sterile inflammation.•Bacteria, viruses…”
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Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation by Heid, Michelle E, Keyel, Peter A, Kamga, Christelle, Shiva, Sruti, Watkins, Simon C, Salter, Russell D

“…The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome drives many inflammatory processes and…”
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Intrinsic repair protects cells from pore-forming toxins by microvesicle shedding by Romero, Matthew, Keyel, Michelle, Shi, Guilan, Bhattacharjee, Pushpak, Roth, Robyn, Heuser, John E, Keyel, Peter A

“…Pore-forming toxins (PFTs) are used by both the immune system and by pathogens to disrupt cell membranes. Cells attempt to repair this disruption in various…”
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Cytokine-induced memory-like natural killer cells by Cooper, Megan A, Elliott, Julie M, Keyel, Peter A, Yang, Liping, Carrero, Javier A, Yokoyama, Wayne M

“…The mammalian immune response to infection is mediated by 2 broad arms, the innate and adaptive immune systems. Innate immune cells are a first-line defense…”
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Interaction of Macrophages and Cholesterol-Dependent Cytolysins: The Impact on Immune Response and Cellular Survival by Thapa, Roshan, Ray, Sucharit, Keyel, Peter A

“…Cholesterol-dependent cytolysins (CDCs) are key virulence factors involved in many lethal bacterial infections, including pneumonia, necrotizing soft tissue…”
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Dnases in health and disease by Keyel, Peter A.

“…DNA degradation is critical to healthy organism development and survival. Two nuclease families that play key roles in development and in disease are the…”
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Multiple Parameters Beyond Lipid Binding Affinity Drive Cytotoxicity of Cholesterol-Dependent Cytolysins by Ray, Sucharit, Thapa, Roshan, Keyel, Peter A

“…The largest superfamily of bacterial virulence factors is pore-forming toxins (PFTs). PFTs are secreted by both pathogenic and non-pathogenic bacteria. PFTs…”
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Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion by Shi, Guilan, Abbott, Kennady N, Wu, Wenbo, Salter, Russell D, Keyel, Peter A

“…Pediatric-onset systemic lupus erythematosus arises in humans and mice lacking the endonuclease Dnase1L3. When Dnase1L3 is absent, DNA from circulating…”
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Continuous engagement of a self-specific activation receptor induces NK cell tolerance by Tripathy, Sandeep K, Keyel, Peter A, Yang, Liping, Pingel, Jeanette T, Cheng, Tammy P, Schneeberger, Achim, Yokoyama, Wayne M

“…Natural killer (NK) cell tolerance mechanisms are incompletely understood. One possibility is that they possess self-specific activation receptors that result…”
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Translational implications of targeting annexin A2: From membrane repair to muscular dystrophy, cardiovascular disease and cancer by Kayejo, Victor G., Fellner, Hannah, Thapa, Roshan, Keyel, Peter A.

“…Background Annexin A2 contributes to several key cellular functions and processes, including membrane repair. Effective repair prevents cell death and…”
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The second transmembrane domain of P2X7 contributes to dilated pore formation by Sun, Chengqun, Heid, Michelle E, Keyel, Peter A, Salter, Russell D

“…Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary…”
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Structural features of Dnase1L3 responsible for serum antigen clearance by McCord, Jon J., Engavale, Minal, Masoumzadeh, Elahe, Villarreal, Johanna, Mapp, Britney, Latham, Michael P., Keyel, Peter A., Sutton, R. Bryan

“…Autoimmunity develops when extracellular DNA released from dying cells is not cleared from serum. While serum DNA is primarily digested by Dnase1 and Dnase1L3,…”
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Molecular Switches Involving the AP-2 β2 Appendage Regulate Endocytic Cargo Selection and Clathrin Coat Assembly by Edeling, Melissa A., Mishra, Sanjay K., Keyel, Peter A., Steinhauser, Amie L., Collins, Brett M., Roth, Robyn, Heuser, John E., Owen, David J., Traub, Linton M.

“…Clathrin-associated sorting proteins (CLASPs) expand the repertoire of endocytic cargo sorted into clathrin-coated vesicles beyond the transmembrane proteins…”
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A single common portal for clathrin-mediated endocytosis of distinct cargo governed by cargo-selective adaptors by Keyel, Peter A, Mishra, Sanjay K, Roth, Robyn, Heuser, John E, Watkins, Simon C, Traub, Linton M

“…Sorting of transmembrane cargo into clathrin-coated vesicles requires endocytic adaptors, yet RNA interference (RNAi)-mediated gene silencing of the AP-2…”
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Methylthioadenosine reprograms macrophage activation through adenosine receptor stimulation by Keyel, Peter A, Romero, Matthew, Wu, Wenbo, Kwak, Daniel H, Zhu, Qin, Liu, Xinyu, Salter, Russell D

“…Regulation of inflammation is necessary to balance sufficient pathogen clearance with excessive tissue damage. Central to regulating inflammation is the switch…”
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Patch repair protects cells from the small pore-forming toxin aerolysin by Thapa, Roshan, Keyel, Peter A

“…Aerolysin family pore-forming toxins damage the membrane, but membrane repair responses used to resist them, if any, remain controversial. Four proposed…”
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Epsin 1 is a Polyubiquitin‐Selective Clathrin‐Associated Sorting Protein by Hawryluk, Matthew J., Keyel, Peter A., Mishra, Sanjay K., Watkins, Simon C., Heuser, John E., Traub, Linton M.

“…Epsin 1 engages several core components of the endocytic clathrin coat, yet the precise mode of operation of the protein remains controversial. The occurrence…”
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Dnase1 Family in Autoimmunity by Engavale, Minal, McCord, Jon, Mapp, Britney, Nzimulinda, Nadine, Bengtson, Elisabeth, Sutton, R. Bryan, Keyel, Peter A.

“…The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that degrades DNA. Loss of Dnase1 family function causes several diseases where the…”
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Reduction of streptolysin O (SLO) pore-forming activity enhances inflammasome activation by Keyel, Peter A, Roth, Robyn, Yokoyama, Wayne M, Heuser, John E, Salter, Russell D

“…Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane…”
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Macrophage responses to bacterial toxins: a balance between activation and suppression by Keyel, Peter A., Heid, Michelle E., Salter, Russell D.

“…Toxins secreted by bacteria can impact the host in a number of different ways. In some infections, toxins play a crucial and central role in pathogenesis…”
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