Search Results - "KewalRamani, Vineet N"

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability by Gres, Anna T., Kirby, Karen A., KewalRamani, Vineet N., Tanner, John J., Pornillos, Owen, Sarafianos, Stefan G.

“…The detailed molecular interactions between native HIV-1 capsid protein (CA) hexamers that shield the viral genome and proteins have been elusive. We report…”
Get full text

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency by Schaller, Torsten, Ocwieja, Karen E, Rasaiyaah, Jane, Price, Amanda J, Brady, Troy L, Roth, Shoshannah L, Hué, Stéphane, Fletcher, Adam J, Lee, KyeongEun, KewalRamani, Vineet N, Noursadeghi, Mahdad, Jenner, Richard G, James, Leo C, Bushman, Frederic D, Towers, Greg J

“…Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The…”
Get full text

The HIV-1 capsid core is an opportunistic nuclear import receptor by Xue, Guangai, Yu, Hyun Jae, Buffone, Cindy, Huang, Szu-Wei, Lee, KyeongEun, Goh, Shih Lin, Gres, Anna T., Guney, Mehmet Hakan, Sarafianos, Stefan G., Luban, Jeremy, Diaz-Griffero, Felipe, KewalRamani, Vineet N.

“…The movement of viruses and other large macromolecular cargo through nuclear pore complexes (NPCs) is poorly understood. The human immunodeficiency virus type…”
Get full text

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection by Luchsinger, Charlotte, Lee, KyeongEun, Mardones, Gonzalo A., KewalRamani, Vineet N., Diaz-Griffero, Felipe

“…The early events of HIV-1 infection involve the transport of the viral core into the nucleus. This event triggers the translocation of CPSF6 from paraspeckles…”
Get full text

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication by Price, Amanda J, Fletcher, Adam J, Schaller, Torsten, Elliott, Tom, Lee, KyeongEun, KewalRamani, Vineet N, Chin, Jason W, Towers, Greg J, James, Leo C

“…The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host…”
Get full text

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats by Winans, Shelby, Yu, Hyun Jae, de los Santos, Kenia, Wang, Gary Z., KewalRamani, Vineet N., Goff, Stephen P.

“…Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into host chromosomal DNA. HIV-1 integration sites are highly…”
Get full text

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration by Jang, Sooin, Bedwell, Gregory J, Singh, Satya P, Yu, Hyun Jae, Arnarson, Bjarki, Singh, Parmit K, Radhakrishnan, Rajalingam, Douglas, AidanDarian W, Ingram, Zachary M, Freniere, Christian, Akkermans, Onno, Sarafianos, Stefan G, Ambrose, Zandrea, Xiong, Yong, Anekal, Praju V, Montero Llopis, Paula, KewalRamani, Vineet N, Francis, Ashwanth C, Engelman, Alan N

“…Abstract HIV-1 integration favors nuclear speckle (NS)-proximal chromatin and viral infection induces the formation of capsid-dependent CPSF6 condensates that…”
Get full text

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection by Wei, Guochao, Iqbal, Naseer, Courouble, Valentine V., Francis, Ashwanth C., Singh, Parmit K., Hudait, Arpa, Annamalai, Arun S., Bester, Stephanie, Huang, Szu-Wei, Shkriabai, Nikoloz, Briganti, Lorenzo, Haney, Reed, KewalRamani, Vineet N., Voth, Gregory A., Engelman, Alan N., Melikyan, Gregory B., Griffin, Patrick R., Asturias, Francisco, Kvaratskhelia, Mamuka

“…Cellular proteins CPSF6, NUP153 and SEC24C play crucial roles in HIV-1 infection. While weak interactions of short phenylalanine-glycine (FG) containing…”
Get full text

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration by Koh, Yasuhiro, Wu, Xiaolin, Ferris, Andrea L, Matreyek, Kenneth A, Smith, Steven J, Lee, KyeongEun, KewalRamani, Vineet N, Hughes, Stephen H, Engelman, Alan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structural basis for nuclear import of splicing factors by human Transportin 3 by Maertens, Goedele N., Cook, Nicola J., Wang, Weifeng, Hare, Stephen, Gupta, Saumya Shree, Öztop, Ilker, Lee, KyeongEun, Pye, Valerie E., Cosnefroy, Ophélie, Snijders, Ambrosius P., KewalRamani, Vineet N., Fassati, Ariberto, Engelman, Alan, Cherepanov, Peter

“…Transportin 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and HIV-1 replication. Herein, we show that the majority of cellular…”
Get full text

Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity by Furtak, Vyacheslav, Mulky, Alok, Rawlings, Stephen A, Kozhaya, Lina, Lee, KyeongEun, Kewalramani, Vineet N, Unutmaz, Derya

“…Exogenous retroviruses are obligate cellular parasites that co-opt a number of host proteins and functions to enable their replication and spread. Several host…”
Get full text

The Requirement for Cellular Transportin 3 (TNPO3 or TRN-SR2) during Infection Maps to Human Immunodeficiency Virus Type 1 Capsid and Not Integrase by KRISHNAN, Lavanya, MATREYEK, Kenneth A, OZTOP, Ilker, LEE, Kyeongeun, TIPPER, Christopher H, XIANG LI, DAR, Mohd J, KEWALRAMANI, Vineet N, ENGELMAN, Alan

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration by Li, Wen, Singh, Parmit K, Sowd, Gregory A, Bedwell, Gregory J, Jang, Sooin, Achuthan, Vasudevan, Oleru, Amarachi V, Wong, Doris, Fadel, Hind J, Lee, KyeongEun, KewalRamani, Vineet N, Poeschla, Eric M, Herschhorn, Alon, Engelman, Alan N

“…Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1)…”
Get full text

HIV-1–induced AIDS in monkeys by Hatziioannou, Theodora, Del Prete, Gregory Q., Keele, Brandon F., Estes, Jacob D., McNatt, Matthew W., Bitzegeio, Julia, Raymond, Alice, Rodriguez, Anthony, Schmidt, Fabian, Trubey, C. Mac, Smedley, Jeremy, Piatak, Michael, KewalRamani, Vineet N., Lifson, Jeffrey D., Bieniasz, Paul D.

“…Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To…”
Get full text

Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection by AMBROSE, Zandrea, LEE, Kyeongeun, KEWALRAMANI, Vineet N, NDJOMOU, Jean, HONGZHAN XU, OZTOP, Ilker, MATOUS, James, TAKEMURA, Taichiro, UNUTMAZ, Derya, ENGELMAN, Alan, HUGHES, Stephen H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6 by LEE, Kyeongeun, MULKY, Alok, YUEN, Wendy, MARTIN, Thomas D, MEYERSON, Nicholas R, CHOI, Laura, YU, Hyun, SAWYER, Sara L, KEWALRAMANI, Vineet N

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors by Selyutina, Anastasia, Hu, Pan, Miller, Sorin, Simons, Lacy M., Yu, Hyun Jae, Hultquist, Judd F., Lee, KyeongEun, KewalRamani, Vineet N., Diaz-Griffero, Felipe

“…The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit…”
Get full text

Co-transcriptional production of RNA-DNA hybrids for simultaneous release of multiple split functionalities by Afonin, Kirill A, Desai, Ravi, Viard, Mathias, Kireeva, Maria L, Bindewald, Eckart, Case, Christopher L, Maciag, Anna E, Kasprzak, Wojciech K, Kim, Taejin, Sappe, Alison, Stepler, Marissa, Kewalramani, Vineet N, Kashlev, Mikhail, Blumenthal, Robert, Shapiro, Bruce A

“…Control over the simultaneous delivery of different functionalities and their synchronized intracellular activation can greatly benefit the fields of RNA and…”
Get full text

A single gp120 residue can affect HIV-1 tropism in macaques by Del Prete, Gregory Q, Keele, Brandon F, Fode, Jeannine, Thummar, Keyur, Swanstrom, Adrienne E, Rodriguez, Anthony, Raymond, Alice, Estes, Jacob D, LaBranche, Celia C, Montefiori, David C, KewalRamani, Vineet N, Lifson, Jeffrey D, Bieniasz, Paul D, Hatziioannou, Theodora

“…Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying…”
Get full text

macaque model of HIV-1 infection by Hatziioannou, Theodora, Ambrose, Zandrea, Chung, Nancy P.Y, Piatak, Michael Jr, Yuan, Fang, Trubey, Charles M, Coalter, Vicky, Kiser, Rebecca, Schneider, Doug, Smedley, Jeremy, Pung, Rhonda, Gathuka, Mercy, Estes, Jacob D, Veazey, Ronald S, KewalRamani, Vineet N, Lifson, Jeffrey D, Bieniasz, Paul D

“…The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to AIDS research; existing models generally employ simian viruses that…”
Get full text