Search Results - "Kew, Kimberly"

Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs by McLaughlin, Kelsey L., Hagen, James T., Coalson, Hannah S., Nelson, Margaret A. M., Kew, Kimberly A., Wooten, Ashley R., Fisher-Wellman, Kelsey H.

“…Human disease pathophysiology commonly involves metabolic disruption at both the cellular and subcellular levels. Isolated mitochondria are a powerful model…”
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Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase by McLaughlin, Kelsey L., Kew, Kimberly A., McClung, Joseph M., Fisher-Wellman, Kelsey H.

“…The mitochondrial mutator mouse is a well-established model of premature aging. In addition to accelerated aging, these mice develop hypertrophic…”
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Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome by Johnson, Jordan M., Ferrara, Patrick J., Verkerke, Anthony R.P., Coleman, Chanel B., Wentzler, Edward J., Neufer, P. Darrell, Kew, Kimberly A., de Castro Brás, Lisandra E., Funai, Katsuhiko

“…Barth Syndrome (BTHS) is an X-linked recessive disorder characterized by cardiomyopathy and muscle weakness. The underlying cause of BTHS is a mutation in the…”
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Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia by Nelson, Margaret Am, McLaughlin, Kelsey L, Hagen, James T, Coalson, Hannah S, Schmidt, Cameron, Kassai, Miki, Kew, Kimberly A, McClung, Joseph M, Neufer, P Darrell, Brophy, Patricia, Vohra, Nasreen A, Liles, Darla, Cabot, Myles C, Fisher-Wellman, Kelsey H

“…Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant…”
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Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients by Nelson, Margaret-Ann M, Efird, Jimmy T, Kew, Kimberly A, Katunga, Lalage A, Monroe, T Blake, Doorn, Jonathan A, Beatty, Cherese N, Shi, Qian, Akhter, Shahab A, Alwair, Hazaim, Robidoux, Jacques, Anderson, Ethan J

“…Catecholamine metabolism monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are…”
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Performance of a High-Pressure Liquid Chromatography-Ion Mobility-Mass Spectrometry System for Metabolic Profiling by Zhang, Xing, Kew, Kimberly, Reisdorph, Richard, Sartain, Mark, Powell, Roger, Armstrong, Michael, Quinn, Kevin, Cruickshank-Quinn, Charmion, Walmsley, Scott, Bokatzian, Samantha, Darland, Ed, Rain, Matthew, Imatani, Ken, Reisdorph, Nichole

“…A commercial liquid chromatography/drift tube ion mobility-mass spectrometer (LC/IM-MS) was evaluated for its utility in global metabolomics analysis…”
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Proteomic identification of tumor- and metastasis-associated galectin-1 in claudin-low breast cancer by Balestrieri, Kassondra, Kew, Kimberly, McDaniel, Moses, Ramez, Mohamed, Pittman, H. Keith, Murray, Gina, Vohra, Nasreen A., Verbanac, Kathryn M.

“…Metastasis and mortality remain high among breast cancer patients with the claudin-low subtype because these tumors are aggressive, chemoresistant, and lack…”
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The Influence of Maternal Aerobic Exercise, Blood DHA and EPA Concentrations on Maternal Lipid Profiles by Strom, Cody J, McDonald, Samantha M, Remchak, Mary-Margaret, Kew, Kimberly A, Rushing, Blake R, Houmard, Joseph A, Tulis, David A, Pawlak, Roman, Kelley, George A, Chasan-Taber, Lisa, Newton, Edward, Isler, Christy, DeVente, James, Raper, Madigan, May, Linda E

“…Exercise and polyunsaturated fatty acid (PUFA) supplementation independently improve lipid profiles. The influence of both exercise and PUFAs on lipids during…”
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Maternal Aerobic Exercise, but Not Blood Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations, during Pregnancy Influence Infant Body Composition by Strom, Cody J., McDonald, Samantha M., Remchak, Mary-Margaret, Kew, Kimberly A., Rushing, Blake R., Houmard, Joseph A., Tulis, David A., Pawlak, Roman, Kelley, George A., Chasan-Taber, Lisa, Newton, Edward, Isler, Christy, DeVente, James, Raper, Madigan, May, Linda E.

“…Although discrete maternal exercise and polyunsaturated fatty acid (PUFA) supplementation individually are beneficial for infant body composition, the effects…”
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Alternative splicing of UCP1 by non-cell-autonomous action of PEMT by Johnson, Jordan M., Verkerke, Anthony R.P., Maschek, J. Alan, Ferrara, Patrick J., Lin, Chien-Te, Kew, Kimberly A., Neufer, P. Darrell, Lodhi, Irfan J., Cox, James E., Funai, Katsuhiko

“…Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl…”
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Screening of Biocatalysts for Synthesis of the Wieland–Miescher Ketone by Mitul P. Patel, Nathaneal T. Green, Jacob K. Burch, Kimberly A. Kew, Robert M. Hughes

“…Lipases, a versatile class of biocatalysts, have been shown to function in non-aqueous media/organic solvents and to possess “promiscuous” catalytic activity…”
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Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish by Wu, Xin-Jun, Williams, Marcus Jermaul, Patel, Pujan Rameshkumar, Kew, Kimberly Ann, Zhu, Yong

“…•Subfertility in pgrmc2−/− in female zebrafish.•Reduced oocyte maturation in pgrmc2−/− in vivo, but not in vitro in zebrafish.•Reduced expression of steroid…”
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Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish by Wu, Xin-Jun, Williams, Marcus Jermaul, Kew, Kimberly Ann, Converse, Aubrey, Thomas, Peter, Zhu, Yong

“…The role G-protein coupled estrogen receptor (GPER) plays in vertebrate reproduction remains controversial. To investigate GPER's reproductive role, we…”
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Forensic Discrimination of Smokeless Powders Using Carbon and Nitrogen Isotope Ratios by Hlohowskyj, Stephan R., Kew, Kimberly, Stern, Libby, Yamnitz, Carl R.

“…Improvised explosive devices pose a threat to the public by way of terrorism and criminal activities. In the United States a commonly used low explosive in…”
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Influence Of Maternal Exercise And DHA Levels During Pregnancy On Maternal Lipids: 822 May 27 3:15 PM - 3:30 PM by Strom, Cody J., Kew, Kimberly, McDonald, Samantha, Isler, Christy, Haven, Kelly, Newton, Ed, May, Linda

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Morphine Resistance in Spinal Cord Injury-Related Neuropathic Pain in Rats is Associated With Alterations in Dopamine and Dopamine-Related Metabolomics by Rodgers, Helen M, Patton, Ryan, Yow, Jacob, Zeczycki, Tonya N, Kew, Kimberly, Clemens, Stefan, Brewer, Kori L

“…Opioids are not universally effective for treating neuropathic pain following spinal cord injury (SCI), a finding that we previously demonstrated in a rat…”
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Maternal Exercise and DHA Levels During Pregnancy Influences Infant Body Composition: 3105 Board #151 May 31 2:00 PM - 3:30 PM by Strom, Cody J., Isler, Christy, Haven, Kelley, Newton, Ed, Kew, Kimberly, Rushing, Blake R., McDonald, Samantha, May, Linda E.

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Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords by Mamillapalli, Srivalli Swathi, Smith-Joyner, Annalisa, Forbes, Lauren, McIntyre, Kadesha, Poppenfuse, Samantha, Rushing, Blake, Strom, Cody, Danell, Allison S., May, Linda, Kuehn, Devon, Kew, Kimberly, Ravisankar, Srikanth

“…Neonatal abstinence syndrome is an array of signs and symptoms experienced by a newborn due to abrupt discontinuation of intrauterine exposure to certain…”
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Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging by Lefcoski, Stephan, Kew, Kimberly, Reece, Shaun, Torres, Maria J., Parks, Justin, Reece, Sky, de Castro Brás, Lisandra E., Virag, Jitka A. I.

“…EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction…”
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