Search Results - "Kew, J N C"

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory by Higgins, G. A., Kew, J. N. C., Richards, J. G., Takeshima, H., Jenck, F., Adam, G., Wichmann, J., Kemp, J. A., Grottick, A. J.

“…Using a combination of the selective opioid receptor‐like1 (ORL1) receptor agonist, Ro 64‐6198, and orphanin FQ/nociceptin (OFQ/N) peptide knockout (KO) mice,…”
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Characterization of a CNS penetrant, selective M 1 muscarinic receptor agonist, 77‐LH‐28‐1 by Langmead, C J, Austin, N E, Branch, C L, Brown, J T, Buchanan, K A, Davies, C H, Forbes, I T, Fry, V A H, Hagan, J J, Herdon, H J, Jones, G A, Jeggo, R, Kew, J N C, Mazzali, A, Melarange, R, Patel, N, Pardoe, J, Randall, A D, Roberts, C, Roopun, A, Starr, K R, Teriakidis, A, Wood, M D, Whittington, M, Wu, Z, Watson, J

“…Background and purpose: M 1 muscarinic ACh receptors (mAChRs) represent an attractive drug target for the treatment of cognitive deficits associated with…”
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Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist by Gill, R, Alanine, A, Bourson, A, Buttelmann, B, Fischer, G, Heitz, M-P, Kew, J N C, Levet-Trafit, B, Lorez, H-P, Malherbe, P, Miss, M-T, Mutel, V, Pinard, E, Roever, S, Schmitt, M, Trube, G, Wybrecht, R, Wyler, R, Kemp, J A

“…Ro 63-1908, 1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol, is a novel subtype-selective N-methyl-D-aspartate (NMDA) antagonist that has…”
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Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77‐LH‐28‐1 by Langmead, C J, Austin, N E, Branch, C L, Brown, J T, Buchanan, K A, Davies, C H, Forbes, I T, Fry, V A H, Hagan, J J, Herdon, H J, Jones, G A, Jeggo, R, Kew, J N C, Mazzali, A, Melarange, R, Patel, N, Pardoe, J, Randall, A D, Roberts, C, Roopun, A, Starr, K R, Teriakidis, A, Wood, M D, Whittington, M, Wu, Z, Watson, J

“…Background and purpose: M1 muscarinic ACh receptors (mAChRs) represent an attractive drug target for the treatment of cognitive deficits associated with…”
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Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1 by Kew, J.N.C, Ducarre, J.-M, Pflimlin, M.-C, Mutel, V, Kemp, J.A

“…Pharmacological activation of metabotropic glutamate receptors (mGluRs) can inhibit synaptic transmission; however, relatively little evidence exists regarding…”
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State‐dependent NMDA receptor antagonism by Ro 8‐4304, a novel NR2B selective, non‐competitive, voltage‐independent antagonist by Kew, James N C., Trube, Gerhard, Kemp, John A.

“…Subunit‐selective blockade of N‐methyl‐D‐aspartate (NMDA) receptors provides a potentially attractive strategy for neuroprotection in the absence of…”
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Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons vitro: Protection by cyclic AMP analogue and high potassium by Kew, J.N.C., Smith, D.W., Sofroniew, M.V.

“…Nerve growth factor regulates the developmental programmed cell death of certain neurons in the peripheral nervous system. The functions of nerve growth factor…”
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Ciliary neurotrophic factor supports p75NGRF-immunoreactive non-cholinergic, but not cholinergic, developing septal neurons in vitro by KEW, J. N. C, SOFRONIEW, M. V

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Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition by Svendsen, CN, Kew, JN, Staley, K, Sofroniew, MV

“…Fetal septal neurons were grown in vitro under glass coverslips. This sandwich culture method significantly increased general neuronal survival, reduced glial…”
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Transfection-mediated expression of human Hsp70i protects rat dorsal root ganglian neurones and glia from severe heat stress by Uney, J.B., Kew, J.N.C., Staley, K., Tyers, P., Sofroniew, M.V.

“…Considerable evidence suggests that the expression of heat shock proteins prior to a toxic insult (e.g. ischaemia, excitoxins, heat) can confer protection to…”
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Brain-derived neurotrophic factor, acidic and basic fibroblast growth factors. Insulin-like growth factor-I, and various antioxidants do not prevent the apoptotic death of developing septal cholinergic neurons following nerve growth factor withdrawal in vitro by KEW, J. N. C, SOFRONIEW, M. V

“…The degree to which growth factors act alone or in combination to influence neuronal survival during the development of the central nervous system is not well…”
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