Search Results - "Kevin Docherty"

Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development by Mazzotta, Silvia, Neves, Carlos, Bonner, Rory J., Bernardo, Andreia S., Docherty, Kevin, Hoppler, Stefan

“…Wnt signaling is a key regulator of vertebrate heart development; however, specific roles for human cardiomyocyte development remain uncertain. Here we use…”
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InGaN/GaN Distributed Feedback Laser Diodes With Deeply Etched Sidewall Gratings by Slight, Thomas J., Odedina, Opeoluwa, Meredith, Wyn, Docherty, Kevin E., Kelly, Anthony E.

“…We report on the design, fabrication, and characterization of InGaN/GaN distributed feedback laser diodes emitting at a single wavelength around 430 nm…”
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Generation of Functional Beta-Like Cells from Human Exocrine Pancreas by Lima, Maria J, Muir, Kenneth R, Docherty, Hilary M, McGowan, Neil W A, Forbes, Shareen, Heremans, Yves, Heimberg, Harry, Casey, John, Docherty, Kevin

“…Transcription factor mediated lineage reprogramming of human pancreatic exocrine tissue could conceivably provide an unlimited supply of islets for…”
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Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells by Rore, Holly, Owen, Nicholas, Piña-Aguilar, Raul Eduardo, Docherty, Kevin, Sekido, Ryohei

“…Regeneration of the testis from pluripotent stem cells is a real challenge, reflecting the complexity of the interaction of germ cells and somatic cells. Here…”
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Alignment verification for electron beam lithography by THORNS, Stephen, MACINTYRE, Douglas S, DOCHERTY, Kevin E, WEAVER, John M. R

“…Alignment between lithography layers is essential for device fabrication. A minor defect in a single marker can lead to incorrect alignment and this can be the…”
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Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture by Muir, Kenneth R, Lima, Maria João, Docherty, Hilary M, McGowan, Neil W A, Forbes, Shareen, Heremans, Yves, Forbes, Stuart J, Heimberg, Harry, Casey, John, Docherty, Kevin

“…A replenishable source of insulin-producing cells has the potential to cure type 1 diabetes. Attempts to culture and expand pancreatic β-cells in vitro have…”
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Relative contribution of PDX-1, MafA and E47/β2 to the regulation of the human insulin promoter by Docherty, Hilary M., Hay, Colin W., Ferguson, Laura A., Barrow, John, Durward, Elaine, Docherty, Kevin

“…The insulin promoter binds a number of tissue-specific and ubiquitous transcription factors. Of these, the homoeodomain protein PDX-1 (pancreatic duodenal…”
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Palmitate enhances the differentiation of mouse embryonic stem cells towards white adipocyte lineages by Petrighi Polidori, Gioia, Lomax, Michael A., Docherty, Kevin

“…► Palmitate programmed embryonic stem cells towards white fat. ► The effects were partially mimicked by 2-bromopalmitate and by the GPR120 analogue GW9508. ►…”
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Pancreatic transcription factors containing protein transduction domains drive mouse embryonic stem cells towards endocrine pancreas by Lima, Maria João, Docherty, Hilary M, Chen, Yuanxiao, Vallier, Ludovic, Docherty, Kevin

“…Protein transduction domains (PTDs), such as the HIV1-TAT peptide, have been previously used to promote the uptake of proteins into a range of cell types,…”
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Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1 by ELRICK, Lucy J, DOCHERTY, Kevin

“…Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1 Lucy J. Elrick and Kevin Docherty Department of Molecular and Cell…”
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Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes by Macfarlane, W M, Frayling, T M, Ellard, S, Evans, J C, Allen, L I, Bulman, M P, Ayres, S, Shepherd, M, Clark, P, Millward, A, Demaine, A, Wilkin, T, Docherty, K, Hattersley, A T

“…The transcription factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of the pancreas and the regulation of insulin gene…”
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Comparative Analysis of Insulin Gene Promoters by Hay, Colin W., Docherty, Kevin

“…Comparative Analysis of Insulin Gene Promoters Implications for Diabetes Research Colin W. Hay and Kevin Docherty From the School of Medical Sciences,…”
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Identification of Adjacent Binding Sites for the YY1 and E4BP4 Transcription Factors in the Ovine PrP (Prion) Gene Promoter by Burgess, Stewart T.G., Shen, Cuicui, Ferguson, Laura A., O’Neill, Gerard T., Docherty, Kevin, Hunter, Nora, Goldmann, Wilfred

“…The PrP gene encodes the cellular isoform of the prion protein (PrPc) which has been shown to be crucial to the development of transmissible spongiform…”
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Transcription factor cycling on the insulin promoter by Barrow, John, Hay, Colin W., Ferguson, Laura A., Docherty, Hilary M., Docherty, Kevin

“…Using MIN6 β-cells and chromatin immunoprecipitation (ChIP) assays, the chronological sequence of binding of MafA, E47/β2 and PDX-1 to the insulin promoter in…”
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Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site by Hay, Colin W, Sinclair, Elaine M, Bermano, Giovanna, Durward, Elaine, Tadayyon, Mohammad, Docherty, Kevin

“…Glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted from the enteroendocrine L-cells of the gut and which acts primarily to potentiate the effects of…”
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Gene therapy for diabetes mellitus by Docherty, K

“…1. This review describes experimental approaches to test the feasibility of using gene therapy to administer insulin to type 1 and type 2 diabetic patients…”
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Glucose Regulates Islet Amyloid Polypeptide Gene Transcription in a PDX1- and Calcium-dependent Manner by Macfarlane, Wendy M., Campbell, Susan C., Elrick, Lucy J., Oates, Victoria, Bermano, Giovanna, Lindley, Keith J., Aynsley-Green, Albert, Dunne, Mark J., James, Roger F.L., Docherty, Kevin

“…Islet amyloid polypeptide (IAPP) and insulin are expressed in the β-cells of the islets of Langerhans. They are co-secreted in response to changes in glucose…”
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Pancreatic stellate cells can form new beta-like cells by Docherty, Kevin

“…Regenerative medicine, including cell-replacement strategies, may have an important role in the treatment of Type 1 and Type 2 diabetes, both of which are…”
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The insulin gene promoter. A simplified nomenclature by German, M, Ashcroft, S, Docherty, K, Edlund, H, Edlund, T, Goodison, S, Imura, H, Kennedy, G, Madsen, O, Melloul, D

“…The tools of molecular biology have rapidly expanded our knowledge of how β-cells regulate insulin gene expression. As this work has progressed in parallel in…”
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ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence by Hay, Colin W., Ferguson, Laura A., Docherty, Kevin

“…The insulin promoter contains a number of dissimilar cis-acting regulatory elements that bind a range of tissue specific and ubiquitous transcription factors…”
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