Search Results - "Kevenaar, Josta T"

The axonal cytoskeleton: from organization to function by Kevenaar, Josta T, Hoogenraad, Casper C

“…The axon is the single long fiber that extends from the neuron and transmits electrical signals away from the cell body. The neuronal cytoskeleton, composed of…”
Get full text

Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity by Kevenaar, Josta T., Bianchi, Sarah, van Spronsen, Myrrhe, Olieric, Natacha, Lipka, Joanna, Frias, Cátia P., Mikhaylova, Marina, Harterink, Martin, Keijzer, Nanda, Wulf, Phebe S., Hilbert, Manuel, Kapitein, Lukas C., de Graaff, Esther, Ahkmanova, Anna, Steinmetz, Michel O., Hoogenraad, Casper C.

“…Kinesin motor proteins play a fundamental role for normal neuronal development by controlling intracellular cargo transport and microtubule (MT) cytoskeleton…”
Get full text

CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor by van der Vaart, Babet, van Riel, Wilhelmina E., Doodhi, Harinath, Kevenaar, Josta T., Katrukha, Eugene A., Gumy, Laura, Bouchet, Benjamin P., Grigoriev, Ilya, Spangler, Samantha A., Yu, Ka Lou, Wulf, Phebe S., Wu, Jingchao, Lansbergen, Gideon, van Battum, Eljo Y., Pasterkamp, R. Jeroen, Mimori-Kiyosue, Yuko, Demmers, Jeroen, Olieric, Natacha, Maly, Ivan V., Hoogenraad, Casper C., Akhmanova, Anna

“…Mechanisms controlling microtubule dynamics at the cell cortex play a crucial role in cell morphogenesis and neuronal development. Here, we identified…”
Get full text

VAP‐SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function by Lindhout, Feline W, Cao, Yujie, Kevenaar, Josta T, Bodzęta, Anna, Stucchi, Riccardo, Boumpoutsari, Maria M, Katrukha, Eugene A, Altelaar, Maarten, MacGillavry, Harold D, Hoogenraad, Casper C

“…In neurons, the continuous and dynamic endoplasmic reticulum (ER) network extends throughout the axon, and its dysfunction causes various axonopathies…”
Get full text

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission by Spangler, Samantha A, Schmitz, Sabine K, Kevenaar, Josta T, de Graaff, Esther, de Wit, Heidi, Demmers, Jeroen, Toonen, Ruud F, Hoogenraad, Casper C

“…The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic…”
Get full text

Liprin- alpha 2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission by Spangler, Samantha A, Schmitz, Sabine K, Kevenaar, Josta T, de Graaff, Esther, de Wit, Heidi, Demmers, Jeroen, Toonen, Ruud F, Hoogenraad, Casper C

“…The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic…”
Get full text

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis by Hol, Elly M., Sluijs, Jacqueline A., Kevenaar, Josta T., van den Berge, Simone A.

“…Dementia is a common feature in Parkinson’s disease (PD) and is considered to be the result of limbic and cortical Lewy bodies and/or Alzheimer changes…”
Get full text

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A by Benoit, Roger M., Frey, Daniel, Hilbert, Manuel, Kevenaar, Josta T., Wieser, Mara M., Stirnimann, Christian U., McMillan, David, Ceska, Tom, Lebon, Florence, Jaussi, Rolf, Steinmetz, Michel O., Schertler, Gebhard F. X., Hoogenraad, Casper C., Capitani, Guido, Kammerer, Richard A.

“…Botulinum neurotoxin A (BoNT/A) is considered the most toxic substance known but is also used as a therapeutic drug for a growing number of diseases and…”
Get full text

Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1 by Schmitz, Sabine K, King, Cillian, Kortleven, Christian, Huson, Vincent, Kroon, Tim, Kevenaar, Josta T, Schut, Desiree, Saarloos, Ingrid, Hoetjes, Joost P, de Wit, Heidi, Stiedl, Oliver, Spijker, Sabine, Li, Ka Wan, Mansvelder, Huibert D, Smit, August B, Cornelisse, Lennart Niels, Verhage, Matthijs, Toonen, Ruud F

“…Presynaptic cannabinoid (CB1R) and metabotropic glutamate receptors (mGluR2/3) regulate synaptic strength by inhibiting secretion. Here, we reveal a…”
Get full text

Presynaptic inhibition upon CB 1 or mG lu2/3 receptor activation requires ERK / MAPK phosphorylation of Munc18‐1 by Schmitz, Sabine K, King, Cillian, Kortleven, Christian, Huson, Vincent, Kroon, Tim, Kevenaar, Josta T, Schut, Desiree, Saarloos, Ingrid, Hoetjes, Joost P, de Wit, Heidi, Stiedl, Oliver, Spijker, Sabine, Li, Ka Wan, Mansvelder, Huibert D, Smit, August B, Cornelisse, Lennart Niels, Verhage, Matthijs, Toonen, Ruud F

Get full text

Liprin-[alpha]2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission by Spangler, Samantha A, Schmitz, Sabine K, Kevenaar, Josta T, de Graaff, Esther, de Wit, Heidi, Demmers, Jeroen, Toonen, Ruud F, Hoogenraad, Casper C

“…The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic…”
Get full text