Search Results - "Keuss, Sarah"

Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (Insight 46): an epidemiological study by Lane, Christopher A, Barnes, Josephine, Nicholas, Jennifer M, Sudre, Carole H, Cash, David M, Parker, Thomas D, Malone, Ian B, Lu, Kirsty, James, Sarah-Naomi, Keshavan, Ashvini, Murray-Smith, Heidi, Wong, Andrew, Buchanan, Sarah M, Keuss, Sarah E, Gordon, Elizabeth, Coath, William, Barnes, Anna, Dickson, John, Modat, Marc, Thomas, David, Crutch, Sebastian J, Hardy, Rebecca, Richards, Marcus, Fox, Nick C, Schott, Jonathan M

“…Midlife hypertension confers increased risk for cognitive impairment in late life. The sensitive period for risk exposure and extent that risk is mediated…”
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Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70 by Keshavan, Ashvini, Pannee, Josef, Karikari, Thomas K, Rodriguez, Juan Lantero, Ashton, Nicholas J, Nicholas, Jennifer M, Cash, David M, Coath, William, Lane, Christopher A, Parker, Thomas D, Lu, Kirsty, Buchanan, Sarah M, Keuss, Sarah E, James, Sarah-Naomi, Murray-Smith, Heidi, Wong, Andrew, Barnes, Anna, Dickson, John C, Heslegrave, Amanda, Portelius, Erik, Richards, Marcus, Fox, Nick C, Zetterberg, Henrik, Blennow, Kaj, Schott, Jonathan M

“…Alzheimer's disease has a preclinical stage when cerebral amyloid-β deposition occurs before symptoms emerge, and when amyloid-β-targeted therapies may have…”
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Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946 by Parker, Thomas D, Cash, David M, Lane, Christopher A S, Lu, Kirsty, Malone, Ian B, Nicholas, Jennifer M, James, Sarah-Naomi, Keshavan, Ashvini, Murray-Smith, Heidi, Wong, Andrew, Buchanan, Sarah M, Keuss, Sarah E, Sudre, Carole H, Modat, Marc, Thomas, David L, Crutch, Sebastian J, Richards, Marcus, Fox, Nick C, Schott, Jonathan M

“…The human hippocampus comprises a number of interconnected histologically and functionally distinct subfields, which may be differentially influenced by…”
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Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort by Lane, Christopher A, Barnes, Josephine, Nicholas, Jennifer M, Sudre, Carole H, Cash, David M, Malone, Ian B, Parker, Thomas D, Keshavan, Ashvini, Buchanan, Sarah M, Keuss, Sarah E, James, Sarah-Naomi, Lu, Kirsty, Murray-Smith, Heidi, Wong, Andrew, Gordon, Elizabeth, Coath, William, Modat, Marc, Thomas, David, Richards, Marcus, Fox, Nick C, Schott, Jonathan M

“…Midlife vascular risk burden is associated with late-life dementia. Less is known about if and how risk exposure in early adulthood influences late-life brain…”
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Subjective cognitive complaints at age 70: associations with amyloid and mental health by Pavisic, Ivanna M., Lu, Kirsty, Keuss, Sarah E., James, Sarah-Naomi, Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Buchanan, Sarah M., Murray-Smith, Heidi, Cash, David M., Coath, William, Wong, Andrew, Fox, Nick C., Crutch, Sebastian J., Richards, Marcus, Schott, Jonathan M.

“…ObjectiveTo investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective…”
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Cognition at age 70: Life course predictors and associations with brain pathologies by Lu, Kirsty, Nicholas, Jennifer M., Collins, Jessica D., James, Sarah-Naomi, Parker, Thomas D., Lane, Christopher A., Keshavan, Ashvini, Keuss, Sarah E., Buchanan, Sarah M., Murray-Smith, Heidi, Cash, David M., Sudre, Carole H., Malone, Ian B., Coath, William, Wong, Andrew, Henley, Susie M.D., Crutch, Sebastian J., Fox, Nick C., Richards, Marcus, Schott, Jonathan M.

“…OBJECTIVETo investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC) and test for…”
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Associations of β-Amyloid and Vascular Burden With Rates of Neurodegeneration in Cognitively Normal Members of the 1946 British Birth Cohort by Keuss, Sarah E., Coath, William, Nicholas, Jennifer M., Poole, Teresa, Barnes, Josephine, Cash, David M., Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Buchanan, Sarah M., Wagen, Aaron Z., Storey, Mathew, Harris, Matthew, Malone, Ian B., Sudre, Carole H., Lu, Kirsty, James, Sarah-Naomi, Street, Rebecca, Thomas, David L., Dickson, John C., Murray-Smith, Heidi, Wong, Andrew, Freiberger, Tamar, Crutch, Sebastian, Richards, Marcus, Fox, Nick C., Schott, Jonathan M.

“…The goals of this work were to quantify the independent and interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a marker…”
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Rates of cortical thinning in Alzheimer’s disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70 by Keuss, Sarah E, Coath, William, Cash, David M, Barnes, Josephine, Nicholas, Jennifer M, Lane, Christopher A, Parker, Thomas D, Keshavan, Ashvini, Buchanan, Sarah M, Wagen, Aaron Z, Storey, Mathew, Harris, Matthew, Lu, Kirsty, James, Sarah-Naomi, Street, Rebecca, Malone, Ian B, Sudre, Carole H, Thomas, David L, Dickson, John C, Barkhof, Frederik, Murray-Smith, Heidi, Wong, Andrew, Richards, Marcus, Fox, Nick C, Schott, Jonathan M

“…BackgroundConsistent patterns of reduced cortical thickness have been identified in early Alzheimer’s disease (AD). However, the pathological factors that…”
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Using a birth cohort to study brain health and preclinical dementia: recruitment and participation rates in Insight 46 by James, Sarah-Naomi, Lane, Christopher A, Parker, Thomas D, Lu, Kirsty, Collins, Jessica D, Murray-Smith, Heidi, Byford, Michelle, Wong, Andrew, Keshavan, Ashvini, Buchanan, Sarah, Keuss, Sarah E, Kuh, Diana, Fox, Nick C, Schott, Jonathan M, Richards, Marcus

“…Identifying and recruiting people with early pre-symptomatic Alzheimer's disease to neuroimaging research studies is increasingly important. The extent to…”
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Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort by James, Sarah-Naomi, Nicholas, Jennifer M., Lu, Kirsty, Keshavan, Ashvini, Lane, Christopher A., Parker, Thomas, Buchanan, Sarah M., Keuss, Sarah E., Murray-Smith, Heidi, Wong, Andrew, Cash, David M., Malone, Ian B., Barnes, Josephine, Sudre, Carole H., Coath, William, Modat, Marc, Ourselin, Sebastien, Crutch, Sebastian J., Kuh, Diana, Fox, Nick C., Schott, Jonathan M., Richards, Marcus

“…Few studies can address how adulthood cognitive trajectories relate to brain health in 70-year-olds. Participants (n = 468, 49% female) from the 1946 British…”
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Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI by Coath, William, Modat, Marc, Cardoso, M. Jorge, Markiewicz, Pawel J., Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Buchanan, Sarah M., Keuss, Sarah E., Harris, Matthew J., Burgos, Ninon, Dickson, John, Barnes, Anna, Thomas, David L., Beasley, Daniel, Malone, Ian B., Wong, Andrew, Erlandsson, Kjell, Thomas, Benjamin A., Schöll, Michael, Ourselin, Sebastien, Richards, Marcus, Fox, Nick C., Schott, Jonathan M., Cash, David M.

“…INTRODUCTION The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As…”
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Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort by Buchanan, Sarah M., Parker, Thomas D., Lane, Christopher A., Keshavan, Ashvini, Keuss, Sarah E., Lu, Kirsty, James, Sarah-Naomi, Murray-Smith, Heidi, Wong, Andrew, Nicholas, Jennifer, Cash, David M., Malone, Ian B., Coath, William, Thomas, David L., Sudre, Carole, Fox, Nick C., Richards, Marcus, Schott, Jonathan M.

“…Objective To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in…”
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Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays by Keshavan, Ashvini, Wellington, Henrietta, Chen, Zhongbo, Khatun, Ayesha, Chapman, Miles, Hart, Melanie, Cash, David M., Coath, William, Parker, Thomas D., Buchanan, Sarah M., Keuss, Sarah E., Harris, Matthew J., Murray‐Smith, Heidi, Heslegrave, Amanda, Fox, Nick C., Zetterberg, Henrik, Schott, Jonathan M

“…INTRODUCTION We assessed the concordance of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau measured on the fully automated Lumipulse platform with…”
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Dissociable effects of APOE -ε4 and β-amyloid pathology on visual working memory by Lu, Kirsty, Nicholas, Jennifer M, Pertzov, Yoni, Grogan, John, Husain, Masud, Pavisic, Ivanna M, James, Sarah-Naomi, Parker, Thomas D, Lane, Christopher A, Keshavan, Ashvini, Keuss, Sarah E, Buchanan, Sarah M, Murray-Smith, Heidi, Cash, David M, Malone, Ian B, Sudre, Carole H, Coath, William, Wong, Andrew, Henley, Susie M D, Fox, Nick C, Richards, Marcus, Schott, Jonathan M, Crutch, Sebastian J

“…Although -ε4 carriers are at significantly higher risk of developing Alzheimer's disease than non-carriers , controversial evidence suggests that -ε4 might…”
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Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study by Wagen, Aaron Z, Coath, William, Keshavan, Ashvini, James, Sarah-Naomi, Parker, Thomas D, Lane, Christopher A, Buchanan, Sarah M, Keuss, Sarah E, Storey, Mathew, Lu, Kirsty, Macdougall, Amy, Murray-Smith, Heidi, Freiberger, Tamar, Cash, David M, Malone, Ian B, Barnes, Josephine, Sudre, Carole H, Wong, Andrew, Pavisic, Ivanna M, Street, Rebecca, Crutch, Sebastian J, Escott-Price, Valentina, Leonenko, Ganna, Zetterberg, Henrik, Wellington, Henrietta, Heslegrave, Amanda, Barkhof, Frederik, Richards, Marcus, Fox, Nick C, Cole, James H, Schott, Jonathan M

“…A neuroimaging-based biomarker termed the brain age is thought to reflect variability in the brain's ageing process and predict longevity. Using Insight 46, a…”
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Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort by Keuss, Sarah E, Parker, Thomas D, Lane, Christopher A, Hoskote, Chandrashekar, Shah, Sachit, Cash, David M, Keshavan, Ashvini, Buchanan, Sarah M, Murray-Smith, Heidi, Wong, Andrew, James, Sarah-Naomi, Lu, Kirsty, Collins, Jessica, Beasley, Daniel G, Malone, Ian B, Thomas, David L, Barnes, Anna, Richards, Marcus, Fox, Nick, Schott, Jonathan M

“…ObjectiveTo summarise the incidental findings detected on brain imaging and blood tests during the first wave of data collection for the Insight 46…”
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Increased variability in reaction time is associated with amyloid beta pathology at age 70 by Lu, Kirsty, Nicholas, Jennifer M., James, Sarah‐Naomi, Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Keuss, Sarah E., Buchanan, Sarah M., Murray‐Smith, Heidi, Cash, David M., Sudre, Carole H., Malone, Ian B., Coath, William, Wong, Andrew, Henley, Susie M.D., Fox, Nick C., Richards, Marcus, Schott, Jonathan M., Crutch, Sebastian J.

“…Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in…”
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Investigating the relationship between BMI across adulthood and late life brain pathologies by Lane, Christopher A, Barnes, Josephine, Nicholas, Jennifer M, Baker, John W, Sudre, Carole H, Cash, David M, Parker, Thomas D, Malone, Ian B, Lu, Kirsty, James, Sarah-Naomi, Keshavan, Ashvini, Buchanan, Sarah, Keuss, Sarah, Murray-Smith, Heidi, Wong, Andrew, Gordon, Elizabeth, Coath, William, Modat, Marc, Thomas, David, Hardy, Rebecca, Richards, Marcus, Fox, Nick C, Schott, Jonathan M

“…In view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body…”
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Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease by Green, Rebecca E, Lord, Jodie, Scelsi, Marzia A, Xu, Jin, Wong, Andrew, Naomi-James, Sarah, Handy, Alex, Gilchrist, Lachlan, Williams, Dylan M, Parker, Thomas D, Lane, Christopher A, Malone, Ian B, Cash, David M, Sudre, Carole H, Coath, William, Thomas, David L, Keuss, Sarah, Dobson, Richard, Legido-Quigley, Cristina, Fox, Nick C, Schott, Jonathan M, Richards, Marcus, Proitsi, Petroula

“…Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for…”
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Gerstmann-Sträussler-Scheinker disease with atypical presentation by Keuss, Sarah E, Ironside, James W, O’Riordan, Jonathan

“…We describe a 37-year-old woman who presented with progressive deafness, visual loss and ataxia. She latterly developed neuropsychiatric problems, including…”
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