Search Results - "Keumoe, Rodrigue"

Proteomic Profiling of Antimalarial Plasmodione Using 3‐Benz(o)ylmenadione Affinity‐Based Probes by Iacobucci, Ilaria, Monaco, Vittoria, Hovasse, Agnès, Dupouy, Baptiste, Keumoe, Rodrigue, Cichocki, Bogdan, Elhabiri, Mourad, Meunier, Brigitte, Strub, Jean‐Marc, Monti, Maria, Cianférani, Sarah, Blandin, Stéphanie A., Schaeffer‐Reiss, Christine, Davioud‐Charvet, Elisabeth

“…Understanding the mechanisms of drug action in malarial parasites is crucial for the development of new drugs to combat infection and to counteract drug…”
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Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 (2,4-Diaminoquinazoline) Unveils Novel Inhibitors of Trypanosoma brucei brucei by Dize, Darline, Tata, Rolland Bantar, Keumoe, Rodrigue, Kouipou Toghueo, Rufin Marie, Tchatat, Mariscal Brice, Njanpa, Cyrille Ngansop, Tchuenguia, Vianey Claire, Yamthe, Lauve Tchokouaha, Fokou, Patrick Valere Tsouh, Laleu, Benoît, Duffy, James, Bishop, Ozlem Tastan, Boyom, Fabrice Fekam

“…New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small…”
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Asymptomatic carriage of Plasmodium falciparum in children living in a hyperendemic area occurs independently of IgG responses but is associated with a balanced inflammatory cytokine ratio by Fogang, Balotin, Schoenhals, Matthieu, Maloba, Franklin M, Biabi, Marie Florence, Essangui, Estelle, Donkeu, Christiane, Cheteug, Glwadys, Kapen, Marie, Keumoe, Rodrigue, Kemleu, Sylvie, Nsango, Sandrine, Cornwall, Douglas H, Eboumbou, Carole, Perraut, Ronald, Megnekou, Rosette, Lamb, Tracey J, Ayong, Lawrence S

“…Asymptomatic carriage of infected red blood cells (iRBCs) can be prevalent in communities regardless of transmission patterns and can occur with infection of…”
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Spirofused tetrahydroisoquinoline-oxindole hybrids as a novel class of fast acting antimalarial agents with multiple modes of action by Efange, Noella M., Lobe, Maloba M. M., Keumoe, Rodrigue, Ayong, Lawrence, Efange, Simon M. N.

“…Molecular hybridization of privileged scaffolds may generate novel antiplasmodial chemotypes that display superior biological activity and delay drug…”
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Ethnobotanical survey of medicinal plants used as insects repellents in six malaria endemic localities of Cameroon by Youmsi, Roger Ducos Fokouo, Fokou, Patrick Valère Tsouh, Menkem, Elisabeth Zeuko'o, Bakarnga-Via, Issakou, Keumoe, Rodrigue, Nana, Victor, Boyom, Fabrice Fekam

“…The combined efforts to combat outdoor/indoor transmission of malaria parasites are hampered by the emerging vector resistance in a wide variety of…”
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In vitro anti-yeast activity, kinetics and mechanism of action of essential oils from two cameroonian medicinal plants by Tchinang, Flore Tatiana Kemegni, Ndoyé Foé, Florentine Marie-Chantal, Keumoe, Rodrigue, Zeuko'o, Elisabeth Menkem, Fekam, Fabrice Boyom, Etoa, François-Xavier

“…Treatment of Candida infections have become increasingly difficult due to antifungal drug resistance, which has drawn attention toward the search for…”
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Potent antiplasmodial extracts and fractions from Terminalia mantaly and Terminalia superba by Mbouna, Cedric D J, Kouipou, Rufin M T, Keumoe, Rodrigue, Tchokouaha, Lauve R Y, Fokou, Patrick V T, Tali, Brice M T, Sahal, Dinkar, Boyom, Fabrice F

“…The emergence and spread of malaria parasites resistant to artemisinin-based combination therapy stresses the need for novel drugs against malaria…”
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Target-Based 6-5 Fused Ring Heterocyclic Scaffolds Display Broad Antiparasitic Potency In Vitro by Dize, Darline, Tali, Mariscal Brice Tchatat, Ngansop, Cyrille Armel Njanpa, Keumoe, Rodrigue, Madiesse Kemgne, Eugenie Aimée, Yamthe, Lauve Rachel Tchokouaha, Tsouh Fokou, Patrick Valere, Pone Kamdem, Boniface, Hata, Katsura, Fekam Boyom, Fabrice

“…Malaria, leishmaniasis, and African trypanosomiasis are protozoan diseases that constitute major global health problems, especially in developing countries;…”
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High prevalence of polyclonal 'Plasmodium falciparum' infections and association with poor IgG antibody responses in a hyper-endemic area in Cameroon by Biabi, Marie Florence A Bite, Fogang, Balotin, Essangui, Estelle, Maloba, Franklin, Donkeu, Christiane, Keumoe, Rodrigue, Cheteug, Glwadys, Magoudjou, Nina, Slam, Celine, Kemleu, Sylvie, Efange, Noella, Perraut, Ronald, Nsango, Sandrine Eveline, Eboumbou Moukoko, Carole Else, Assam, Jean Paul Assam, Etoa, François-Xavier, Lamb, Tracey, Ayong, Lawrence

“…Malaria remains a major public health problem worldwide, with eradication efforts thwarted by drug and insecticide resistance and the lack of a broadly…”
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Identification of 3,3′-O-dimethylellagic acid and apigenin as the main antiplasmodial constituents of Endodesmia calophylloides Benth and Hymenostegia afzelii (Oliver.) Harms by Keumoe, Rodrigue, Koffi, Jean Garba, Dize, Darline, Fokou, Patrick Valère Tsouh, Tchamgoue, Joseph, Ayong, Lawrence, Ndjakou, Bruno Lenta, Sewald, Norbert, Ngameni, Bathelemy, Boyom, Fabrice Fekam

“…Abstract Background Endodesmia calophylloides and Hymenostegia afzelii belong to the Guttiferae and Caesalpiniaceae plant families with known uses in African…”
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In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei by Fekam Boyom, Fabrice, Gounoue Kamkumo, Raceline, Sahebkar, Amirhossein, Keumoe, Rodrigue, Tsakem Nangap, Jaures Marius, Tsouh Fokou, Patrick Valere, Yamthe Tchokouaha, Lauve Rachel, Jiatsa Mbouna, Cedric Derick, Tchatat Tali, Mariscal Brice, Bakarnga-via, Issakou

“…Background. Terminalia mantaly is used in Cameroon traditional medicine to treat malaria and related symptoms. However, its antiplasmodial efficacy is still to…”
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Cover Feature: Proteomic Profiling of Antimalarial Plasmodione Using 3‐Benz(o)ylmenadione Affinity‐Based Probes (ChemBioChem 15/2024) by Iacobucci, Ilaria, Monaco, Vittoria, Hovasse, Agnès, Dupouy, Baptiste, Keumoe, Rodrigue, Cichocki, Bogdan, Elhabiri, Mourad, Meunier, Brigitte, Strub, Jean‐Marc, Monti, Maria, Cianférani, Sarah, Blandin, Stéphanie A., Schaeffer‐Reiss, Christine, Davioud‐Charvet, Elisabeth

“…Antimalarial plasmodione‐based pro‐photoaffinity probes for protein profiling ((pro‐) AfBPP) based on the 3‐benz(o)yl‐6‐fluoro‐menadione scaffold were designed…”
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High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon by Fogang, Balotin, Biabi, Marie Florence, Megnekou, Rosette, Maloba, Franklin M, Essangui, Estelle, Donkeu, Christiane, Cheteug, Glwadys, Kapen, Marie, Keumoe, Rodrigue, Kemleu, Sylvie, Nsango, Sandrine, Eboumbou, Carole, Lamb, Tracey J, Ayong, Lawrence

“…Asymptomatic malarial parasitemia is highly prevalent in Plasmodium falciparum endemic areas and often associated with increased prevalence of mild to moderate…”
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Implementation and continued validation of the malaria Plasmodium falciparum lactate dehydrogenase-based colorimetric assay for use in antiplasmodial drug screening by Fokou, Patrick Valere Tsouh, Tali, Brice Mariscal Tchatat, Dize, Darline, Mbouna, Cedric Derick Jiatsa, Ngansop, Cyrille Armel Njampa, Keumoe, Rodrigue, Tchokouaha, Lauve Rachel Yamthe, Tchouankeu, Jean Claude, Escudie, Fanny, Duffy, James, Boyom, Fabrice Fekam

“…Antimalarial drug discovery has been facilitated by the development of various in vitro drug susceptibility testing methods suitable for medium-throughput or…”
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In vitro antiplasmodial activity-directed investigation and UPLC–MS fingerprint of promising extracts and fractions from Terminalia ivorensis A. Chev. and Terminalia brownii Fresen by Tali, Mariscal Brice Tchatat, Dize, Darline, Njonte Wouamba, Steven Collins, Tsouh Fokou, Patrick Valere, Keumoe, Rodrigue, Ngansop, Cyrille Njanpa, Nguembou Njionhou, Michelle Sidoine, Jiatsa Mbouna, Cedric Derick, Yamthe Tchokouaha, Lauve Rachel, Maharaj, Vinesh, Khorommbi, Ndivhuwo Kevin, Naidoo-Maharaj, Dashnie, Tchouankeu, Jean Claude, Boyom, Fabrice Fekam

“…ETHNOPHARMACOLOGICAL SIGNIFICANCEMedicinal plants from the Terminalia genus are widely used as remedies against many infectious diseases, including malaria. As…”
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Preliminary Structure–Activity Relationship Study of the MMV Pathogen Box Compound MMV675968 Unveils Novel Inhibitors of ITrypanosoma brucei brucei/I by Dize, Darline, Tata, Rolland Bantar, Keumoe, Rodrigue, Kouipou Toghueo, Rufin Marie, Tchatat, Mariscal Brice, Njanpa, Cyrille Ngansop, Tchuenguia, Vianey Claire, Yamthe, Lauve Tchokouaha, Fokou, Patrick Valere Tsouh, Laleu, Benoît, Duffy, James, Bishop, Ozlem Tastan, Boyom, Fabrice Fekam

“…New drugs are urgently needed for the treatment of human African trypanosomiasis (HAT). In line with our quest for novel inhibitors of trypanosomes, a small…”
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Specific sub fractions from Terminalia mantaly (H. Perrier) extracts potently inhibit Plasmodium falciparum rings, merozoite egress and invasion by Jiatsa Mbouna, Cedric Derick, Tchatat Tali, Brice Mariscal, Tsouh Fokou, Patrick Valere, Madiesse Kemgne, Eugenie Aimee, Keumoe, Rodrigue, Toghueo Kouipou, Rufin Marie, Yamthe Tchokouaha, Lauve Rachel, Tchuente Tchuenmogne, Marthe Aimée, Kenou, Donald Kagho, Sahal, Dinkar, Boyom, Fabrice Fekam

“…Terminalia mantaly (H. Perrier) and Terminalia superba (Engl. & Diels) are sources of treatment for various diseases, including malaria and/or related symptoms…”
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3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies by Dupouy, Baptiste, Donzel, Maxime, Roignant, Matthieu, Charital, Sarah, Keumoe, Rodrigue, Yamaryo-Botté, Yoshiki, Feckler, Alexander, Bundschuh, Mirco, Bordat, Yann, Rottmann, Matthias, Mäser, Pascal, Botté, Cyrille, Blandin, Stéphanie, Besteiro, Sébastien, Davioud-Charvet, Elisabeth

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Chemical constituents of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) and their chemophenetic significance by Bouzeko, Inest Larissa T., Dongmo, Faustine Léonie M., Ndontsa, Blanche Laure, Ngansop, Cyrille Armel N., Keumoe, Rodrigue, Bitchagno, Gabin Thierry M., Jouda, Jean Bosco, Mbouangouere, Roukayatou, Tchegnitegni, Billy Toussie, Boyom, Fabrice Fekam, Sewald, Norbert, Lenta, Bruno Ndjakou, Tane, Pierre, Ngouela, Silvère Augustin, Tene, Mathieu

“…The chemical investigation of the CH2Cl2/MeOH (1:1) extract from the aerial part of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) resulted in the…”
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Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae) by Kayo, Maurice Taboula, Simo, Marguerite Kamdem, Tagatsing Fotsing, Maurice, Talla, Emmanuel, Laurent, Sophie, Elst, Luce Vander, Henoumont, Céline, Yankep, Emmanuel, Alfred Ngenge, Tamfu, Keumoe, Rodrigue, Atchade, Alex de Theodore, Zeukóo, Elisabeth Menkem, Sameza, Modeste Lambert, Roch, Alain, Muller, Robert, Boyom, Fabrice Fekam, Mbafor, Joseph Tanyi

“…Phytochemical study of Uvaria comperei afforded an alkaloid, 8,9-dimethoxy-5H-phenanthridin-6-one (1), isolated and characterised (assignment of 1 H and 13 C…”
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