Search Results - "Keul, Petra"

Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders by Flögel, Ulrich, Temme, Sebastian, Jacoby, Christoph, Oerther, Thomas, Keul, Petra, Flocke, Vera, Wang, Xiaowei, Bönner, Florian, Nienhaus, Fabian, Peter, Karlheinz, Schrader, Jürgen, Grandoch, Maria, Kelm, Malte, Levkau, Bodo

“…Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel…”
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Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis by Keul, Petra, Lucke, Susann, von Wnuck Lipinski, Karin, Bode, Constantin, Gräler, Markus, Heusch, Gerd, Levkau, Bodo

“…RATIONALE:The role of sphingosine-1-phosphate (S1P) and its receptors in the pathogenesis of atherosclerosis has not been investigated. OBJECTIVE:We…”
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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss by Weske, Sarah, Vaidya, Mithila, Reese, Alina, von Wnuck Lipinski, Karin, Keul, Petra, Bayer, Julia K, Fischer, Jens W, Flögel, Ulrich, Nelsen, Jens, Epple, Matthias, Scatena, Marta, Schwedhelm, Edzard, Dörr, Marcus, Völzke, Henry, Moritz, Eileen, Hannemann, Anke, Rauch, Bernhard H, Gräler, Markus H, Heusch, Gerd, Levkau, Bodo

“…Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show that…”
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Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus by Kohlmorgen, Christina, Gerfer, Stephen, Feldmann, Kathrin, Twarock, Sören, Hartwig, Sonja, Lehr, Stefan, Klier, Meike, Krüger, Irena, Helten, Carolin, Keul, Petra, Kahl, Sabine, Polzin, Amin, Elvers, Margitta, Flögel, Ulrich, Kelm, Malte, Levkau, Bodo, Roden, Michael, Fischer, Jens W., Grandoch, Maria

“…Aims/hypothesis People with diabetes have an increased cardiovascular risk with an accelerated development of atherosclerosis and an elevated mortality rate…”
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Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages by Vaidya, Mithila, Jentsch, Julian A., Peters, Susann, Keul, Petra, Weske, Sarah, Gräler, Markus H., Mladenov, Emil, Iliakis, George, Heusch, Gerd, Levkau, Bodo

“…Sphingolipid and cholesterol metabolism are closely associated at the structural, biochemical, and functional levels. Although HDL-associated…”
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Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice by Weske, Sarah, Vaidya, Mithila, von Wnuck Lipinski, Karin, Keul, Petra, Manthe, Kristina, Burkhart, Christoph, Haberhauer, Gebhard, Heusch, Gerd, Levkau, Bodo

“…Osteoporosis is a worldwide epidemic but pharmacological agents to stimulate new bone formation are scarce. We have shown that increasing tissue levels of…”
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Sphingosine-1-phosphate suppresses GLUT activity through PP2A and counteracts hyperglycemia in diabetic red blood cells by Thomas, Nadine, Schröder, Nathalie H., Nowak, Melissa K., Wollnitzke, Philipp, Ghaderi, Shahrooz, von Wnuck Lipinski, Karin, Wille, Annalena, Deister-Jonas, Jennifer, Vogt, Jens, Gräler, Markus H., Dannenberg, Lisa, Buschmann, Tobias, Westhoff, Philipp, Polzin, Amin, Kelm, Malte, Keul, Petra, Weske, Sarah, Levkau, Bodo

“…Red blood cells (RBC) are the major carriers of sphingosine-1-phosphate (S1P) in blood. Here we show that variations in RBC S1P content achieved by altering…”
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Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction by Polzin, Amin, Dannenberg, Lisa, Benkhoff, Marcel, Barcik, Maike, Helten, Carolin, Mourikis, Philipp, Ahlbrecht, Samantha, Wildeis, Laura, Ziese, Justus, Zikeli, Dorothee, Metzen, Daniel, Hu, Hao, Baensch, Leonard, Schröder, Nathalie H., Keul, Petra, Weske, Sarah, Wollnitzke, Philipp, Duse, Dragos, Saffak, Süreyya, Cramer, Mareike, Bönner, Florian, Müller, Tina, Gräler, Markus H., Zeus, Tobias, Kelm, Malte, Levkau, Bodo

“…Antiplatelet medication is standard of care in acute myocardial infarction (AMI). However, it may have obscured beneficial properties of the activated platelet…”
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Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin by Nussbaum, Claudia, Bannenberg, Sarah, Keul, Petra, Gräler, Markus H., Gonçalves-de-Albuquerque, Cassiano F., Korhonen, Hanna, von Wnuck Lipinski, Karin, Heusch, Gerd, de Castro Faria Neto, Hugo C., Rohwedder, Ina, Göthert, Joachim R., Prasad, Vysakh Pushpa, Haufe, Günter, Lange-Sperandio, Baerbel, Offermanns, Stefan, Sperandio, Markus, Levkau, Bodo

“…Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in…”
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE−/−  Mice by Keul, Petra, Peters, Susann, von Wnuck Lipinski, Karin, Schröder, Nathalie H., Nowak, Melissa K., Duse, Dragos A., Polzin, Amin, Weske, Sarah, Gräler, Markus H., Levkau, Bodo

“…Altered plasma sphingosine-1-phosphate (S1P) concentrations are associated with clinical manifestations of atherosclerosis. However, whether long-term…”
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Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease by Sattler, Katherine J. E., Elbasan, Şehriban, Keul, Petra, Elter-Schulz, Miriam, Bode, Constantin, Gräler, Markus H., Bröcker-Preuss, Martina, Budde, Thomas, Erbel, Raimund, Heusch, Gerd, Levkau, Bodo

“…High-density lipoproteins (HDL) are the major plasma carriers for sphingosine 1-phosphate (S1P) in healthy individuals, but their S1P content is unknown for…”
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HDL-Associated Lysosphingolipids Inhibit NAD(P)H Oxidase–Dependent Monocyte Chemoattractant Protein-1 Production by Tölle, Markus, Pawlak, Alicja, Schuchardt, Miriam, Kawamura, Akira, Tietge, Uwe J, Lorkowski, Stefan, Keul, Petra, Assmann, Gerd, Chun, Jerold, Levkau, Bodo, van der Giet, Markus, Nofer, Jerzy-Roch

“…OBJECTIVES—High-density lipoprotein (HDL) levels are inversely proportional to the risk of atherosclerosis, but mechanisms of HDL atheroprotection remain…”
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Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning by Keul, Petra, Borren, Marcel M. G. J., Ghanem, Alexander, Müller, Frank Ulrich, Baartscheer, Antonius, Verkerk, Arie O., Stümpel, Frank, Schulte, Jan Sebastian, Hamdani, Nazha, Linke, Wolfgang A., Loenen, Pieter, Matus, Marek, Schmitz, Wilhelm, Stypmann, Jörg, Tiemann, Klaus, Ravesloot, Jan‐Hindrik, Alewijnse, Astrid E., Hermann, Sven, Spijkers, Léon J. A., Hiller, Karl‐Heinz, Herr, Deron, Heusch, Gerd, Schäfers, Michael, Peters, Stephan L. M., Chun, Jerold, Levkau, Bodo

“…Background Sphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The…”
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Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content by Sattler, Katherine, MD, Gräler, Markus, PhD, Keul, Petra, PhD, Weske, Sarah, MSc, Reimann, Christina-Maria, MSc, Jindrová, Helena, MSc, Kleinbongard, Petra, PhD, Sabbadini, Roger, PhD, Bröcker-Preuss, Martina, MD, Erbel, Raimund, MD, Heusch, Gerd, MD, Levkau, Bodo, MD

“…Abstract Background Sphingosine-1-phosphate (S1P) is a constituent of high-density lipoproteins (HDL) that contributes to their beneficial effects. We have…”
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Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1 by Polzin, Amin, Dannenberg, Lisa, Benkhoff, Marcel, Barcik, Maike, Keul, Petra, Ayhan, Aysel, Weske, Sarah, Ahlbrecht, Samantha, Trojovsky, Kajetan, Helten, Carolin, Haberkorn, Sebastian, Flögel, Ulrich, Zeus, Tobias, Müller, Tina, Gräler, Markus H., Kelm, Malte, Levkau, Bodo

“…Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces…”
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HDL and its sphingosine-1-phosphate content in cardioprotection by Keul, Petra, Sattler, Katherine, Levkau, Bodo

“…Increasing evidence suggests that High-density lipoproteins (HDL) are a direct cardioprotective agent in the setting of acute myocardial ischemia/reperfusion…”
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Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number by LEVKAU, Bodo, SCHÄFERS, Michael, STEGGER, Lars, FLÖGEL, Ulrich, SCHRADER, Jürgen, FISCHER, Jens, HSIEH, Patrick, OU, Yen-Ling, MEHRHOF, Felix, TIEMANN, Klaus, GHANEM, Alexander, MATUS, Marek, WOHLSCHLAEGER, Jeremias, NEUMANN, Joachim, HEUSCH, Gerd, SCHMID, Kurt W, CONWAY, Edward M, BABA, Hideo A, VON WNUCK LIPINSKI, Karin, KEUL, Petra, HERMANN, Sven, KAWAGUCHI, Naomasa, KIRCHHOF, Paulus, FABRITZ, Larissa, STYPMANN, Jörg

“…Survivin inhibits apoptosis and regulates cell division in many organs, but its function in the heart is unknown. We show that cardiac-specific deletion of…”
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Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P3 by Tölle, Markus, Levkau, Bodo, Keul, Petra, Brinkmann, Volker, Giebing, Günter, Schönfelder, Gilbert, Schäfers, Michael, von Wnuck Lipinski, Karin, Jankowski, Joachim, Jankowski, Vera, Chun, Jerold, Zidek, Walter, van der Giet, Markus

“…The novel immunomodulator FTY720 is effective in experimental models of transplantation and autoimmunity, and is currently undergoing Phase III clinical trials…”
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Potent anti‐inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL‐S1P and their impairment in coronary artery disease due to lower HDL‐S1P: a new aspect of HDL dysfunction and its therapy by Keul, Petra, Polzin, Amin, Kaiser, Klaus, Gräler, Markus, Dannenberg, Lisa, Daum, Günter, Heusch, Gerd, Levkau, Bodo

“…ABSTRACT Dysfunctional HDL is associated with coronary artery disease (CAD), but its effect on inflammation in vascular smooth muscle cells (VSMCs) in…”
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Synthesis, radiosynthesis and biochemical evaluation of fluorinated analogues of sphingosine-1-phosphate receptor 3 specific antagonists using PET by Prasad, Vysakh Puspha, Wagner, Stefan, Keul, Petra, Hermann, Sven, Levkau, Bodo, Schäfers, Michael, Haufe, Günter

“…[Display omitted] •New fluorinated sphingosine-1-phosphate receptor 3 (S1P3) antagonists have been synthesized.•The most active one was 18F-labelled for…”
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