Search Results - "Keul, Nicholas D."

The entropic force generated by intrinsically disordered segments tunes protein function by Keul, Nicholas D., Oruganty, Krishnadev, Schaper Bergman, Elizabeth T., Beattie, Nathaniel R., McDonald, Weston E., Kadirvelraj, Renuka, Gross, Michael L., Phillips, Robert S., Harvey, Stephen C., Wood, Zachary A.

“…Protein structures are dynamic and can explore a large conformational landscape 1 , 2 . Only some of these structural substates are important for protein…”
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Hysteresis and Allostery in Human UDP-Glucose Dehydrogenase Require a Flexible Protein Core by Beattie, Nathaniel R, Pioso, Brittany J, Sidlo, Andrew M, Keul, Nicholas D, Wood, Zachary A

“…Human UDP-glucose dehydrogenase (hUGDH) oxidizes UDP-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity…”
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Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase by Beattie, Nathaniel R, Keul, Nicholas D, Hicks Sirmans, Tiffany N, McDonald, Weston E, Talmadge, Trevor M, Taujale, Rahil, Kannan, Natarajan, Wood, Zachary A

“…Human UDP-glucose dehydrogenase (hUGDH) oxidizes uridine diphosphate (UDP)-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of…”
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1,2-Propanediol Dehydration in Roseburia inulinivorans: STRUCTURAL BASIS FOR SUBSTRATE AND ENANTIOMER SELECTIVITY by LaMattina, Joseph W, Keul, Nicholas D, Reitzer, Pierre, Kapoor, Suraj, Galzerani, Felipe, Koch, Daniel J, Gouvea, Iuri E, Lanzilotta, William N

“…Glycyl radical enzymes (GREs) represent a diverse superfamily of enzymes that utilize a radical mechanism to catalyze difficult, but often essential, chemical…”
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Anaerobic Heme Degradation: ChuY Is an Anaerobilin Reductase That Exhibits Kinetic Cooperativity by LaMattina, Joseph W, Delrossi, Michael, Uy, Katherine G, Keul, Nicholas D, Nix, David B, Neelam, Anudeep R, Lanzilotta, William N

“…Heme catabolism is an important biochemical process that many bacterial pathogens utilize to acquire iron. However, tetrapyrrole catabolites can be reactive…”
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An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights into Uncoupling of Oxygen Consumption from Substrate Hydroxylation by Binda, Claudia, Robinson, Reeder M., Martin del Campo, Julia S., Keul, Nicholas D., Rodriguez, Pedro J., Robinson, Howard H., Mattevi, Andrea, Sobrado, Pablo

“…N-Hydroxylating monooxygenases are involved in the biosynthesis of iron-chelating hydroxamate-containing siderophores that play a role in microbial virulence…”
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Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase by Beattie, Nathaniel R, Keul, Nicholas D, Sidlo, Andrew M, Wood, Zachary A

“…Human UDP-glucose dehydrogenase (hUGDH) is regulated by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose (UDP-Xyl) competes with the…”
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The structural and biochemical impacts of monomerizing human acetylcholinesterase by Bester, Stephanie M., Adipietro, Kaylin A., Funk, Vanessa L., Myslinski, James M., Keul, Nicholas D., Cheung, Jonah, Wilder, Paul T., Wood, Zachary A., Weber, David J., Height, Jude J., Pegan, Scott D.

“…Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Hence, there is an active…”
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Hysteresis in Human UDP-Glucose Dehydrogenase Is Due to a Restrained Hexameric Structure That Favors Feedback Inhibition by Kadirvelraj, Renuka, Custer, Gregory S, Keul, Nicholas D, Sennett, Nicholas C, Sidlo, Andrew M, Walsh, Richard M, Wood, Zachary A

“…Human UDP-α-d-glucose-6-dehydrogenase (hUGDH) displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). Here we…”
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The role of intrinsic disorder in human UDP-glucose dehydrogenase by Keul, Nicholas D., Kadirvelraj, Renuka, Oruganty, Krishnadev, Polizzi, Samuel J., Wood, Zachary A.

“…Abstract only…”
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1,2-Propanediol Dehydration in Roseburia inulinivorans by LaMattina, Joseph W., Keul, Nicholas D., Reitzer, Pierre, Kapoor, Suraj, Galzerani, Felipe, Koch, Daniel J., Gouvea, Iuri E., Lanzilotta, William N.

“…Glycyl radical enzymes (GREs) represent a diverse superfamily of enzymes that utilize a radical mechanism to catalyze difficult, but often essential, chemical…”
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Understanding hysteresis in human UDP-glucose dehydrogenase by Wood, Zachary A., Beattie, Nathaniel R., Gross, Phillip M., Kadirvelraj, Renu, Keul, Nicholas D., McDonald, Weston E.

“…Abstract only…”
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An Unprecedented NADPH Domain Conformation in Lysine Monooxygenase NbtG Provides Insights into Uncoupling of Oxygen Consumption from Substrate Hydroxylation by Binda, Claudia, Robinson, Reeder M., Martin del Campo, Julia S., Keul, Nicholas D., Rodriguez, Pedro J., Robinson, Howard H., Mattevi, Andrea, Sobrado, Pablo

“…N-hydroxylating monooxygenases (NMOs) are involved in the biosynthesis of iron-chelating hydroxamate-containing siderophores that play a role in microbial…”
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