Search Results - "Keubler, Lydia M"

Running in the wheel: Defining individual severity levels in mice by Häger, Christine, Keubler, Lydia M, Talbot, Steven R, Biernot, Svenja, Weegh, Nora, Buchheister, Stephanie, Buettner, Manuela, Glage, Silke, Bleich, André

“…The fine-scale grading of the severity experienced by animals used in research constitutes a key element of the 3Rs (replace, reduce, and refine) principles…”
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Time to Integrate to Nest Test Evaluation in a Mouse DSS-Colitis Model by Häger, Christine, Keubler, Lydia M, Biernot, Svenja, Dietrich, Jana, Buchheister, Stephanie, Buettner, Manuela, Bleich, André

“…Severity assessment in laboratory animals is an important issue regarding the implementation of the 3R concept into biomedical research and pivotal in current…”
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A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse by Keubler, Lydia M, Buettner, Manuela, Häger, Christine, Bleich, André

“…Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic…”
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Systematic review and meta-analysis of the effect of fecal microbiota transplantation on behavior in animals by Keubler, Lydia M., Talbot, Steven R., Bleich, André, Boyle, Erin C.

“…The bi-directional interaction between gut microbiota and the central nervous system has been coined the gut microbiota-brain axis. Fecal microbiota…”
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CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function by Buchheister, Stephanie, Buettner, Manuela, Basic, Marijana, Noack, Andreas, Breves, Gerhard, Buchen, Barbara, Keubler, Lydia M, Becker, Christoph, Bleich, André

“…Intestinal homeostasis disturbance through intestinal barrier disruption presumably plays a key role in inflammatory bowel disease (IBD) development. Genetic…”
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Where are we heading? Challenges in evidence-based severity assessment by Keubler, Lydia M, Hoppe, Nils, Potschka, Heidrun, Talbot, Steven R, Vollmar, Brigitte, Zechner, Dietmar, Häger, Christine, Bleich, André

“…Evidence-based severity assessment in laboratory animals is, apart from the ethical responsibility, imperative to generate reproducible, standardized and valid…”
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Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice by Basic, Marijana, Keubler, Lydia M, Buettner, Manuela, Achard, Marcel, Breves, Gerhard, Schröder, Bernd, Smoczek, Anna, Jörns, Anne, Wedekind, Dirk, Zschemisch, Nils H, Günther, Claudia, Neumann, Detlef, Lienenklaus, Stefan, Weiss, Siegfried, Hornef, Mathias W, Mähler, Michael, Bleich, André

“…Infection may trigger clinically overt mucosal inflammation in patients with predisposition for inflammatory bowel disease. However, the impact of particular…”
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Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation by Basic, Marijana, Buettner, Manuela, Keubler, Lydia M., Smoczek, Anna, Bruesch, Inga, Buchheister, Stephanie, Bleich, André

“…The TLR4 co-receptor CD14 was identified as an IBD candidate gene. Here, its influence on the intestinal barrier was addressed utilizing E. coli Nissle (EcN),…”
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Mo1918 CD14-Dependent B Cell Response Plays an Important Role in Intestinal Barrier Maintenance After E. Coli Nissle Monoassociation by Basic, Marijana, Buettner, Manuela, Keubler, Lydia M, Smoczek, Anna, Förster, Reinhold, Bleich, Andre

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Measurement of corticosterone in mice: a protocol for a mapping review by Leenaars, Cathalijn H.C., van der Mierden, Stevie, Durst, Mattea, Goerlich-Jansson, Vivian C, Ripoli, Florenza Lüder, Keubler, Lydia M, Talbot, Steven R, Boyle, Erin, Habedank, Anne, Jirkof, Paulin, Lewejohann, Lars, Gass, Peter, Tolba, René, Bleich, André

“…Severity assessment for experiments conducted with laboratory animals is still based mainly on subjective evaluations; evidence-based methods are scarce…”
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Sa1755 Norovirus Infection Support Mucosal Inflammation in Germfree Mice After Schaedler Flora Colonization by Basic, Marijana, Keubler, Lydia M, Buettner, Manuela, Smoczek, Anna, Bleich, Andre

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Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database by Van der Mierden, Stevie, Leenaars, Cathalijn H C, Boyle, Erin C, Ripoli, Florenza L, Gass, Peter, Durst, Mattea, Goerlich-Jansson, Vivian C, Jirkof, Paulin, Keubler, Lydia M, Talbot, Steven R, Habedank, Anne, Lewejohann, Lars, Tolba, Rene H, Bleich, André

“…Evaluating stress in laboratory animals is a key principle in animal welfare. Measuring corticosterone is a common method to assess stress in laboratory mice…”
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Quantitative phenotyping of inflammatory bowel disease in the IL-10-deficient mouse by use of noninvasive magnetic resonance imaging by Michael, Svenja, Keubler, Lydia M, Smoczek, Anna, Meier, Martin, Gunzer, Florian, Pöhlmann, Christoph, Krause-Buchholz, Udo, Hedrich, Hans-J, Bleich, André

“…Although magnetic resonance imaging (MRI) is an increasingly used diagnostic tool in the assessment of inflammatory bowel disease (IBD) in humans, diagnosis…”
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Mo1782 Disruption of the TLR4 Pathway Leads to Dysfunction of the Intestinal Barrier in an Escherichia coli Nissle Monoassociation Model - Implication for Experimental Inflammatory Bowel Disease Susceptibility by Basic, Marijana, Keubler, Lydia M, Smoczek, Anna, Liese, Andrea, Hedrich, Hans J, Bleich, Andre

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Mo1752 Murine Norovirus Infection Induces Structural and Functional Intestinal Barrier Changes in the Il10-Deficient Mouse Model of Inflammatory Bowel Disease by Keubler, Lydia M, Basic, Marijana, Smoczek, Anna, Jörns, Anne, Burmester, Marion, Schröder, Bernd, Breves, Gerhard, Hedrich, Hans J, Bleich, Andre

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Hygienic monitoring of Mongolian gerbils: which mouse viruses should be included? by Bleich, Eva-M, Keubler, Lydia M, Smoczek, Anna, Mähler, Michael, Bleich, André

“…The Mongolian gerbil (Meriones unguiculatus) serves as an animal model for a wide range of diseases. A practical limitation in its use is the definition of the…”
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