Search Results - "Kettyle, Laura M.J."

Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene‐Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia by Ramsey, Joanne M., Kettyle, Laura M.J., Sharpe, Daniel J., Mulgrew, Nuala M., Dickson, Glenda J., Bijl, Janet J., Austin, Pamela, Mayotte, Nadine, Cellot, Sonia, Lappin, Terence R.J., Zhang, Shu‐Dong, Mills, Ken I., Krosl, Jana, Sauvageau, Guy, Thompson, Alexander

“…The incidence of refractory acute myeloid leukemia (AML) is on the increase due in part to an aging population that fails to respond to traditional therapies…”
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c‐Met inhibition in a HOXA9/Meis1 model of CN‐AML by Mulgrew, Nuala M., Kettyle, Laura M.J., Ramsey, Joanne M., Cull, Susan, Smyth, Laura J., Mervyn, Danielle M., Bijl, Janet J., Thompson, Alexander

“…ABSTRACT Background: Hematopoiesis is a paradigm for developmental processes, hierarchically organized, with stem cells at its origin. Hematopoietic stem cells…”
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Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia by Kettyle, Laura M J, Liberante, Fabio G, Thompson, Alexander

“…Drug discovery and development are often hampered by lack of target identification and clinical tractability. Repurposing of approved drugs to life-threatening…”
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Low-dose salinomycin induces anti-leukemic responses in AML and MLL by Roulston, Gary D R, Burt, Charlotte L, Kettyle, Laura M J, Matchett, Kyle B, Keenan, Heather L, Mulgrew, Nuala M, Ramsey, Joanne M, Dougan, Caoifa, McKiernan, John, Grishagin, Ivan V, Mills, Ken I, Thompson, Alexander

“…Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are…”
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