Search Results - "Ketting, Rene F."

The Many Faces of RNAi by Ketting, René F.

“…Small non-coding RNAs, through association with Argonaute protein family members, have a variety of functions during the development of an organism. Although…”
Get full text

Zili is required for germ cell differentiation and meiosis in zebrafish by Houwing, Saskia, Berezikov, Eugene, Ketting, René F

“…Small RNAs exert an effect through diverse RNA interference pathways to transcriptionally or post‐transcriptionally silence their targets. The Piwi‐interacting…”
Get full text

MUT-7 exoribonuclease activity and localization are mediated by an ancient domain by Busetto, Virginia, Pshanichnaya, Lizaveta, Lichtenberger, Raffael, Hann, Stephan, Ketting, René F, Falk, Sebastian

“…Abstract The MUT-7 family of 3′–5′ exoribonucleases is evolutionarily conserved across the animal kingdom and plays essential roles in small RNA production in…”
Get full text

Maternal piRNAs Are Essential for Germline Development following De Novo Establishment of Endo-siRNAs in Caenorhabditis elegans by de Albuquerque, Bruno F.M., Placentino, Maria, Ketting, René F.

“…The Piwi-piRNA pathway represents a germline-specific transposon-defense system. C. elegans Piwi, prg-1, is a non-essential gene and triggers a secondary RNAi…”
Get full text

How stress can affect your sex appeal by Schreier, Jan, Ketting, René F

“…In this issue of Developmental Cell, Toker et al. show that in C. elegans, stress-induced sperm defects lead to epigenetically heritable increased sexual…”
Get full text

Profiling of RNA modifications by multiplexed stable isotope labelling by Kellner, Stefanie, Neumann, Jennifer, Rosenkranz, David, Lebedeva, Svetlana, Ketting, René F, Zischler, Hans, Schneider, Dirk, Helm, Mark

“…The combination of (15)N/(13)C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10…”
Get more information

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways by Almeida, Miguel Vasconcelos, de Jesus Domingues, António Miguel, Ketting, René F

“…Endogenous small RNAs (sRNAs) and Argonaute proteins are ubiquitous regulators of gene expression in germline and somatic tissues. sRNA-Argonaute complexes are…”
Get full text

Trimming it short: PNLDC1 is required for piRNA maturation during mouse spermatogenesis by Bronkhorst, Alfred W, Ketting, René F

“…Transposon silencing within the germ line requires the proper processing of piRNA intermediates. However, the enzyme that is required for piRNA 3′ end…”
Get full text

Concepts and functions of small RNA pathways in C. elegans by Ketting, René F, Cochella, Luisa

“…A diversity of gene regulatory mechanisms drives the changes in gene expression required for animal development. Here, we discuss the developmental roles of a…”
Get full text

Tupaia small RNAs provide insights into function and evolution of RNAi-based transposon defense in mammals by Rosenkranz, David, Rudloff, Stefanie, Bastuck, Katharina, Ketting, René F, Zischler, Hans

“…Argonaute proteins comprising Piwi-like and Argonaute-like proteins and their guiding small RNAs combat mobile DNA on the transcriptional and…”
Get full text

Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish by Redl, Stefan, de Jesus Domingues, Antonio M, Caspani, Edoardo, Möckel, Stefanie, Salvenmoser, Willi, Mendez-Lago, Maria, Ketting, René F

“…Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about…”
Get full text

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles by Volz, Ann-Kathrin, Frei, Alina, Kretschmer, Viola, de Jesus Domingues, António M., Ketting, Rene F., Ueffing, Marius, Boldt, Karsten, Krämer-Albers, Eva-Maria, May-Simera, Helen L.

“…Primary cilia are microtubule based sensory organelles important for receiving and processing cellular signals. Recent studies have shown that cilia also…”
Get full text

Substrate requirements for let-7 function in the developing zebrafish embryo by Kloosterman, Wigard P, Wienholds, Erno, Ketting, René F, Plasterk, Ronald H A

Get full text

piRNAs from Pig Testis Provide Evidence for a Conserved Role of the Piwi Pathway in Post-Transcriptional Gene Regulation in Mammals by Gebert, Daniel, Ketting, René F, Zischler, Hans, Rosenkranz, David

“…Piwi-interacting (pi-) RNAs guide germline-expressed Piwi proteins in order to suppress the activity of transposable elements (TEs). But notably, the majority…”
Get full text

MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation by Phillips, Carolyn M., Montgomery, Brooke E., Breen, Peter C., Roovers, Elke F., Rim, Young-Soo, Ohsumi, Toshiro K., Newman, Martin A., van Wolfswinkel, Josien C., Ketting, Rene F., Ruvkun, Gary, Montgomery, Taiowa A.

“…More than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized small interfering RNA (siRNA) amplification module which…”
Get full text

PIWI-interacting RNAs: from generation to transgenerational epigenetics by Luteijn, Maartje J., Ketting, René F.

“…Key Points PIWI-interacting RNAs (piRNAs) are made from dedicated precursor transcripts that are transcribed from specialized loci. piRNA biogenesis from their…”
Get full text

A Dead End for MicroRNAs by Ketting, René F.

“…Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide…”
Get full text

Semiconserved Regulation of Mesendoderm Differentiation by microRNAs by Ketting, René F.

“…MicroRNAs are known to play important roles in many different processes. However, their roles in shaping the early steps in embryogenesis have remained largely…”
Get full text

RNAi genes pave their own way by Kamminga, Leonie M, Ketting, René F

“…Heterochromatin formation in fission yeast and the role of RNAi in this process have been intensively studied. So far, however, nothing is known about the…”
Get full text

Is This Mine? Small RNAs Help to Decide by de Albuquerque, Bruno F.M., Ketting, René F.

“…Genomes are constantly challenged by invaders, so determining what belongs is crucial. Small RNAs silence alien DNA, but Conine et al. (2013), Seth et al…”
Get full text