Effect of Contact Lens Wear on the Release of Tear Mediators in Keratoconus

OBJECTIVES:The release of different cytokines and mediators in tears of patients with keratoconus (KC) wearing contact lenses (CLs) may contribute to the pathology of KC. METHODS:Cohort study was established in patients with KC wearing rigid gas permeable (RGP) CL (group I), patients with ametropia...

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Published in:	Eye & contact lens Vol. 39; no. 2; pp. 147 - 152
Main Authors:	Fodor, Mariann, Kolozsvári, Bence L, Petrovski, Goran, Kettesy, Beáta A, Gogolák, Péter, Rajnavölgyi, Éva, Ujhelyi, Bernadett, Módis, László, Petrovski, Beáta É, Szima, Georgina Z, Berta, András, Facskó, Andrea
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-03-2013
Subjects:	Adult Analysis of Variance Biomarkers - metabolism Cohort Studies Contact Lenses, Hydrophilic Cytokines - secretion Eye Proteins - secretion Female Humans Keratoconus - metabolism Male Matrix Metalloproteinases - secretion Middle Aged Tears - metabolism Young Adult
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Summary:	OBJECTIVES:The release of different cytokines and mediators in tears of patients with keratoconus (KC) wearing contact lenses (CLs) may contribute to the pathology of KC. METHODS:Cohort study was established in patients with KC wearing rigid gas permeable (RGP) CL (group I), patients with ametropia wearing silicone hydrogel (Si-Hi) CL (group II) and ametropic patients wearing RGP CL (group III). RESULTS:Our findings indicate that before CL wear, the release of epidermal growth factor (EGF) and tissue-type plasminogen activator (t-PA) was attenuated, whereas matrix metalloproteinase (MMP)-9, interleukin (IL)-6, chemokine (C-C motif) ligand 5 (CCL5), IL-13, and plasminogen activator inhibitor (PAI)-1 were enhanced in KC compared with ametropes. An increasing linear trend over time was found for MMP-9, EGF, and CXCL8 in KC and MMP-9, MMP-13, IL-6, and CXCL8 in group III. Significant differences were observed in the linear trend over time between groups I and III for MMP-13 and tissue inhibitor of metalloproteinases (TIMP)-1; between groups I and II for MMP-9 and CXCL8; and between groups III and II for MMP-9, CXCL8, and MMP-13. In KC, the release of MMP-9 at week 6 and nerve growth factor (NGF) at 10 min was higher, but NGF at week 2 was lower than that in group II. The release of MMP-13 and NGF at week 2 and 6 were lower in the KC group as compared with group III, and similarly, with IL-6 and CXCL8 at week 2 and PAI at all time points. CONCLUSIONS:Contact lens wear can influence the levels and dynamics of various mediators in the tears of patients with KC that might have an impact on the progression of the disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1542-2321 1542-233X
DOI:	10.1097/ICL.0b013e318273b35f