Search Results - "Ketterer, Margaret R"

The phospholipase A of Neisseria gonorrhoeae lyses eukaryotic membranes and is necessary for survival in neutrophils and cervical epithelial cells by Apicella, Michael A, Edwards, Jennifer L, Ketterer, Margaret R, Weiss, David S, Zhang, Yuan, Jen, Freda E-C, Jennings, Michael P

“…Contact-dependent hemolysins are virulence factors in a number of human pathogens, including entero-invasive and . Here we demonstrate that produces an outer…”
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Lipooligosaccharide Ligands from Respiratory Bacterial Pathogens Enhance Cellular Uptake of Nanoparticles by Tu, Mai H., Brenza, Timothy M., Ketterer, Margaret R., Timm, Morgan, King, Benjamin M., Apicella, Michael A., Fiegel, Jennifer

“…Several bacterial pathogens contain membrane ligands that facilitate their binding and internalization into human tissues. In this study, lipooligosaccharides…”
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The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea by Jen, Freda E-C, Ketterer, Margaret R, Semchenko, Evgeny A, Day, Christopher J, Seib, Kate L, Apicella, Michael A, Jennings, Michael P

“…The lipooligosaccharide (LOS) of plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process…”
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Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins by Coombs, Gary S., Rios-Monterrosa, Jose L., Lai, Shuping, Dai, Qiang, Goll, Ashley C., Ketterer, Margaret R., Valdes, Maria F., Uche, Nnamdi, Benjamin, Ivor J., Wallrath, Lori L.

“…Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA…”
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Identification and characterization of AckA-dependent protein acetylation in Neisseria gonorrhoeae by Post, Deborah M B, Schilling, Birgit, Reinders, Lorri M, D'Souza, Alexandria K, Ketterer, Margaret R, Kiel, Steven J, Chande, Aroon T, Apicella, Michael A, Gibson, Bradford W

“…Neisseria gonorrhoeae, the causative agent of gonorrhea, has a number of factors known to contribute to pathogenesis; however, a full understanding of these…”
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Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy by Shaw, Nicholas M, Rios-Monterrosa, Jose L, Fedorchak, Gregory R, Ketterer, Margaret R, Coombs, Gary S, Lammerding, Jan, Wallrath, Lori L

“…The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is…”
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Characterization of a nontypeable Haemophilus influenzae thermonuclease by Cho, Christine, Chande, Aroon T, Gakhar, Lokesh, Hunt, Jason, Ketterer, Margaret R, Apicella, Michael A

“…Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during…”
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Gonococcal Cervicitis: A Role for Biofilm in Pathogenesis by Steichen, Christopher T., Shao, Jian Q., Ketterer, Margaret R., Apicella, Michael A.

“…Neisseria gonorrhoeae forms a biofilm in flow cells on glass coverslips as well as on primary cervical epithelial cells. Electron microscopic studies of…”
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Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence by Ulland, Tyler K, Buchan, Blake W, Ketterer, Margaret R, Fernandes-Alnemri, Teresa, Meyerholz, David K, Apicella, Michael A, Alnemri, Emad S, Jones, Bradley D, Nauseef, William M, Sutterwala, Fayyaz S

“…The mechanisms by which the intracellular pathogen Francisella tularensis evades innate immunity are not well defined. We have identified a gene with homology…”
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Desialylation of Neisseria gonorrhoeae Lipooligosaccharide by Cervicovaginal Microbiome Sialidases: The Potential for Enhancing Infectivity in Men by Ketterer, Margaret R., Rice, Peter A., Gulati, Sunita, Kiel, Steven, Byerly, Luke, Fortenberry, J. Dennis, Soper, David E., Apicella, Michael A.

“…Previous studies have demonstrated that Neisseria gonorrhoeae sialylates the terminal N-acetyllactosamine present on its lipooligosaccharide (LOS) by acquiring…”
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Recombinant truncated AniA of pathogenic Neisseria elicits a non-native immune response and functional blocking antibodies by Shewell, Lucy K., Ku, Shan C., Schulz, Benjamin L., Jen, Freda E.-C., Mubaiwa, Tsitsi D., Ketterer, Margaret R., Apicella, Michael A., Jennings, Michael P.

“…► AniA of Neisseria gonorrhoeae is surface exposed. ► The O-linked monosaccharide of the AniA glycoprotein is immunodominant. ► Removal of the glycan results…”
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Comparative Analyses of the Lipooligosaccharides from Nontypeable Haemophilus influenzae and Haemophilus haemolyticus Show Differences in Sialic Acid and Phosphorylcholine Modifications by Post, Deborah M B, Ketterer, Margaret R, Coffin, Jeremy E, Reinders, Lorri M, Munson, Jr, Robert S, Bair, Thomas, Murphy, Timothy F, Foster, Eric D, Gibson, Bradford W, Apicella, Michael A

“…Haemophilus haemolyticus and nontypeable Haemophilus influenzae (NTHi) are closely related upper airway commensal bacteria that are difficult to distinguish…”
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Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry by Post, Deborah M B, Held, Jason M, Ketterer, Margaret R, Phillips, Nancy J, Sahu, Alexandria, Apicella, Michael A, Gibson, Bradford W

“…Non-typeable H. influenzae (NTHi) is a nasopharyngeal commensal that can become an opportunistic pathogen causing infections such as otitis media, pneumonia,…”
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Quantification of confocal images of biofilms grown on irregular surfaces by Sommerfeld Ross, Stacy, Tu, Mai Han, Falsetta, Megan L., Ketterer, Margaret R., Kiedrowski, Megan R., Horswill, Alexander R., Apicella, Michael A., Reinhardt, Joseph M., Fiegel, Jennifer

“…Bacterial biofilms grow on many types of surfaces, including flat surfaces such as glass and metal and irregular surfaces such as rocks, biological tissues and…”
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The msbB Mutant of Neisseria meningitidis Strain NMB Has a Defect in Lipooligosaccharide Assembly and Transport to the Outer Membrane by POST, Deborah M. B, KETTERER, Margaret R, PHILLIPS, Nancy J, GIBSON, Bradford W, APICELLA, Michael A

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Infection of Primary Human Bronchial Epithelial Cells by Haemophilus influenzae: Macropinocytosis as a Mechanism of Airway Epithelial Cell Entry by KETTERER, M. R, SHAO, J. Q, HORNICK, D. B, BUSCHER, B, BANDI, V. K, APICELLA, M. A

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Macropinocytosis as a Mechanism of Entry into Primary Human Urethral Epithelial Cells by Neisseria gonorrhoeae by ZENNI, M. K, GIARDINA, P. C, HARVEY, H. A, JIANQIANG SHAO, KETTERER, M. R, LUBAROFF, D. M, WILLIAMS, R. D, APICELLA, M. A

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Lipooligosaccharide Ligands from Respiratory Bacterial Pathogens Enhance Cellular Uptake of Nanoparticles by Tu, Mai H., Brenza, Timothy M., Ketterer, Margaret R., Timm, Morgan, King, Benjamin M., Apicella, Michael A., Fiegel, Jennifer

“…Several bacterial pathogens contain membrane ligands that facilitate their binding and internalization into human tissues. In this study, lipooligosaccharides…”
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Binding of the non‐typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signalling by Swords, W. Edward, Ketterer, Margaret R., Shao, Jianqiang, Campbell, Colleen A., Weiser, Jeffrey N., Apicella, Michael A.

“…Non‐typeable Haemophilus influenzae (NTHi) invades host cells by binding of the platelet‐activating factor (PAF) receptor via lipooligosaccharide (LOS)…”
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Ultrastructural analysis of primary human urethral epithelial cell cultures infected with Neisseria gonorrhoeae by HARVEY, H. A, KETTERER, M. R, PRESTON, A, LUBAROFF, D, WILLIAMS, R, APICELLA, M. A

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