Search Results - "Kettenbach, Arminja"

Substrate and phosphorylation site selection by phosphoprotein phosphatases by Nguyen, Hieu, Kettenbach, Arminja N.

“…Global mass spectrometry-based phosphoproteomic analyses have revealed preferences of phosphoprotein phosphatases (PPPs) for distinct phosphorylation site…”
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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen by Pallesen, Jesper, Wang, Nianshuang, Corbett, Kizzmekia S., Wrapp, Daniel, Kirchdoerfer, Robert N., Turner, Hannah L., Cottrell, Christopher A., Becker, Michelle M., Wang, Lingshu, Shi, Wei, Kong, Wing-Pui, Andres, Erica L., Kettenbach, Arminja N., Denison, Mark R., Chappell, James D., Graham, Barney S., Ward, Andrew B., McLellan, Jason S.

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human…”
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Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily by Nasa, Isha, Kettenbach, Arminja N

“…Phosphoprotein Phosphatases (PPPs) are enzymes highly conserved from yeast and human and catalyze the majority of the serine and threonine dephosphorylation in…”
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Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy by Ohnstad, Amelia E, Delgado, Jose M, North, Brian J, Nasa, Isha, Kettenbach, Arminja N, Schultz, Sebastian W, Shoemaker, Christopher J

“…Autophagosome formation requires multiple autophagy‐related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to…”
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Rapid and Reproducible Single-Stage Phosphopeptide Enrichment of Complex Peptide Mixtures: Application to General and Phosphotyrosine-Specific Phosphoproteomics Experiments by Kettenbach, Arminja N, Gerber, Scott A

“…Reversible protein phosphorylation is an essential regulatory component of virtually every cellular process and is frequently dysregulated in cancer. However,…”
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A complex containing lysine-acetylated actin inhibits the formin INF2 by A, Mu, Fung, Tak Shun, Kettenbach, Arminja N., Chakrabarti, Rajarshi, Higgs, Henry N.

“…Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal…”
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Metabolic phosphatase moonlights for proteins by Gerber, Scott A., Kettenbach, Arminja N.

“…In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical ‘moonlighting’ functions of metabolic enzymes. A study now…”
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The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora by Wang, Bin, Kettenbach, Arminja N., Zhou, Xiaoying, Loros, Jennifer J., Dunlap, Jay C.

“…In the negative feedback loop driving fungal and animal circadian oscillators, negative elements (FREQUENCY [FRQ], PERIODS [PERs], and CRYPTOCHROMES [CRYs])…”
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Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition by Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.

“…Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are…”
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R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation by Caudron-Herger, Maiwen, Rusin, Scott F., Adamo, Mark E., Seiler, Jeanette, Schmid, Vera K., Barreau, Elsa, Kettenbach, Arminja N., Diederichs, Sven

“…The comprehensive but specific identification of RNA-binding proteins as well as the discovery of RNA-associated protein functions remain major challenges in…”
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Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells by Kettenbach, Arminja N, Schweppe, Devin K, Faherty, Brendan K, Pechenick, Dov, Pletnev, Alexandre A, Gerber, Scott A

“…Mitosis is a process involving a complex series of events that require careful coordination. Protein phosphorylation by a small number of kinases, in…”
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Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins by Nasa, Isha, Rusin, Scott F, Kettenbach, Arminja N, Moorhead, Greg B

“…Protein phosphatase 1 (PP1) is a highly conserved protein phosphatase that performs most of the serine- and threonine-dephosphorylation reactions in eukaryotes…”
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Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics by Petrone, Adam, Adamo, Mark E., Cheng, Chao, Kettenbach, Arminja N.

“…Cyclin-dependent kinase 1 (Cdk1) is an essential regulator of many mitotic processes including the reorganization of the cytoskeleton, chromosome segregation,…”
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Inducible Protein Degradation as a Strategy to Identify Phosphoprotein Phosphatase 6 Substrates in RAS-Mutant Colorectal Cancer Cells by Mariano, Natasha C., Rusin, Scott F., Nasa, Isha, Kettenbach, Arminja N.

“…Protein phosphorylation is an essential regulatory mechanism that controls most cellular processes, including cell cycle progression, cell division, and…”
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Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptides by Gerber, Scott A, Kettenbach, Arminja N, Rush, John

“…In the analysis of biological systems, it is of interest to identify the components of the system and to monitor their changes in abundance under different…”
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A protein phosphatase 1 specific phos phatase ta rgeting p eptide (PhosTAP) to identify the PP1 phosphatome by Choy, Meng S, Nguyen, Hieu T, Kumar, Ganesan S, Peti, Wolfgang, Kettenbach, Arminja N, Page, Rebecca

“…Phosphoprotein phosphatases (PPPs) are the key serine/threonine phosphatases that regulate all essential signaling cascades. In particular, Protein Phosphatase…”
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A protein phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome by Choy, Meng S, Nguyen, Hieu T, Kumar, Ganesan S, Peti, Wolfgang, Kettenbach, Arminja N, Page, Rebecca

“…Phosphoprotein phosphatases (PPPs) are the key serine/threonine phosphatases that regulate all essential signaling cascades. In particular, Protein Phosphatase…”
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Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR by Yore, Mark M, Kettenbach, Arminja N, Sporn, Michael B, Gerber, Scott A, Liby, Karen T

“…New multifunctional drugs that target multiple disease-relevant networks offer a novel approach to the prevention and treatment of many diseases. New synthetic…”
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Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits by Kruse, Thomas, Gnosa, Sebastian Peter, Nasa, Isha, Garvanska, Dimitriya Hristoforova, Hein, Jamin B, Nguyen, Hieu, Samsøe‐Petersen, Jacob, Lopez‐Mendez, Blanca, Hertz, Emil Peter Thrane, Schwarz, Jeanette, Pena, Hanna Sofia, Nikodemus, Denise, Kveiborg, Marie, Kettenbach, Arminja N, Nilsson, Jakob

“…PP2A is an essential protein phosphatase that regulates most cellular processes through the formation of holoenzymes containing distinct regulatory B‐subunits…”
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Evaluation of Quantification and Normalization Strategies for Phosphoprotein Phosphatase Affinity Proteomics: Application to Breast Cancer Signaling by Brauer, Brooke L., Wiredu, Kwame, Gerber, Scott A., Kettenbach, Arminja N.

“…Accurate quantification of proteomics data is essential for revealing and understanding biological signaling processes. We have recently developed a chemical…”
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