Search Results - "Ketelhuth, D."

Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans by Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, S. A., Schwartz, T. W., Paulsson‐Berne, G., Hansson, G. K., Hedin, U., Ketelhuth, D. F. J.

“…Background The metabolism of tryptophan (Trp) along the kynurenine pathway has been shown to carry strong immunoregulatory properties. Several experimental…”
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Vaccination against T‐cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis by Gisterå, A., Hermansson, A., Strodthoff, D., Klement, M. L., Hedin, U., Fredrikson, G. N., Nilsson, J., Hansson, G. K., Ketelhuth, D. F. J.

“…Background and Objectives The T‐cell response to low‐density lipoprotein (LDL) in the vessel wall plays a critical role in atherosclerotic plaque formation and…”
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PCSK6 ablation increases atherosclerotic burden, but provides plaque stability by regulating TH17 and smooth muscle cell content by Matic, L., Suur, B., Karadimou, G., Willems, C., Bergman, O., Lengquist, M., Kronqvist, M., Baumgartner, R., Malin, S., Gisterå, A., Hansson, G., Mälarstig, A., Hedin, U., Ketelhuth, D.

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The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field by Polyzos, K A, Ketelhuth, D F J

“…Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of…”
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Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells by Ma, Z, Ketelhuth, D F J, Wirström, T, Ohki, T, Forteza, M J, Wang, H, Grill, V, Wollheim, C B, Björklund, A

“…Modified lipoproteins can negatively affect beta cell function and survival. However, the mechanisms behind interactions of modified lipoproteins with beta…”
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Mycobacterium bovis BCG killed by extended freeze‐drying induces an immunoregulatory profile and protects against atherosclerosis by Ovchinnikova, O. A., Berge, N., Kang, C., Urien, C., Ketelhuth, D. F. J., Pottier, J., Drouet, L., Hansson, G. K., Marchal, G., Bäck, M., Schwartz‐Cornil, I., Lagranderie, M.

“…Objectives Atherosclerosis is an inflammatory disease of the arterial wall that leads to myocardial infarction and stroke. Regulatory T cells (Tregs) and IL‐10…”
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Platelet-Specific Expression Of The Inflammatory Nf-Κb Activator Ikk2 Reduces Atherosclerosis And Protects Mice From Hepatosteatosis by Mussbacher, M., Salzmann, M., Schrottmaier Cornelia, W., Kral-Poitner Barbara, J., Marak, R., Basilio, J., Binder J, C., Ketelhuth, D., Assinger, A., Schmid A, J.

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Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice by Casquero, A.C., Berti, J.A., Salerno, A.G., Bighetti, E.J.B., Cazita, P.M., Ketelhuth, D.F.J., Gidlund, M., Oliveira, H.C.F.

“…In this work, we investigated the impact of testosterone deficiency and cholesteryl ester transfer protein (CETP) expression on lipoprotein metabolism and…”
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Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall by Ketelhuth, D F J, Hansson, G K

“…Atherosclerosis is a chronic inflammatory disease. Atherosclerotic plaques contain abundant immune cells that can dictate and effect inflammatory responses…”
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Autoantibody Response to Chromatographic Fractions from Oxidized LDL in Unstable Angina Patients and Healthy Controls by Ketelhuth, D.F.J, Tonini, G.C, Carvalho, M.D.T, Ramos, R.F, Boschcov, P, Gidlund, M

“…Levels of autoantibodies to oxidized low-density lipoprotein (oxLDL) have been correlated to atherosclerosis; however, contradictory results have been shown…”
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Increased microvascular permeability in the hamster cheek pouch induced by oxidized low density lipoprotein (oxLDL) and some fragmented apolipoprotein B proteins by Svensjö, E, Boschcov, P, Ketelhuth, D F J, Jancar, S, Gidlund, M

“…Oxidized low-density lipoproteins (oxLDL) and protein fractions obtained by size exclusion chromatography of oxLDL were tested for vascular permeability…”
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The immunometabolic role of pyruvate dehydrogenase kinase-1 in smooth muscle cells in atherosclerosis by Grentzmann, Andrietta, Tripodi, Gustavo Luis, Nilsson, Michelle Duen, Zelzer, Elazar, Forteza, Maria José, Steffensen, Lasse, Ketelhuth, Daniel

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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, ismodifiable, and associates with future cardiovascular deaths by Ruuth, M., Nguyen, S. D., Vihervaara, T., Hilvo, M., Laajala, T. D., Kondadi, Pradeep Kumar, Gistera, A., Lahteenmaki, H., Kittila, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M. L., Nieminen, M. S., Jula, A., Perola, M., Yla-Herttula, S., Rudel, L., Oorni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Kakela, R., Boren, J., Williams, K. J., Kovanen, P. T., Oorni, K.

“…Aims Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation…”
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IB kinase 2 in atherosclerosis by Mussbacher, M., Salzmann, M., Volek, H.K., Kuttke, M., Basilio, J., Hösel, B., Assinger, A., Ketelhuth, D., Schmid, J.A.

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I B kinase 2 in atherosclerosis by Mussbacher, M., Salzmann, M., Volek, H.K., Kuttke, M., Basilio, J., Hösel, B., Assinger, A., Ketelhuth, D., Schmid, J.A.

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Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis by Lundberg, Anna M, Ketelhuth, Daniel F J, Johansson, Maria E, Gerdes, Norbert, Liu, Sang, Yamamoto, Masahiro, Akira, Shizuo, Hansson, Göran K

“…Members of the Toll-like receptor (TLR) family initiate innate immune responses and were recently shown to play a role in atherosclerosis. However, the…”
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CTLA-4 induces IDO1 enzymatic activity in dermal dendritic cells from UVB-treated skin by Martini, E, Hoffer, E, Cheuk, S, Ketelhuth, D, Eidsmo, L

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Instability of LDL particles predicts future cardiovascular deaths by Ruuth, Maija, Nguyen, Su Duy, Vihervaara, Terhi, Hilvo, Mika, Laajala, Teemu Daniel, Kondadi, Pradeep Kumar, Anton, Gisterå, Huusko, Jenni, Uusitupa, Matti, Schwab, Ursula, Lawrence, Rudel, Ketelhuth, Daniel, Laaksonen, Reijo, Baumann, Marc, Aittokallio, Tero, Jauhiainen, Matti, Jan, Borén, Williams, Kevin Jon, Kovanen, Petri, Öörni, Katariina

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Identification of a Danger-Associated Peptide From Apolipoprotein B100 (ApoBDS-1) That Triggers Innate Proatherogenic Responses by KETELHUTH, Daniel F. J, RIOS, Francisco J. O, YAN, Zhong-Qun, YAJUAN WANG, HUIQING LIU, JOHANSSON, Maria E, FREDRIKSON, Gunilla N, HEDIN, Ulf, GIDLUND, Magnus, NILSSON, Jan, HANSSON, Göran K

“…Subendothelial deposited low-density lipoprotein particles are a known inflammatory factor in atherosclerosis. However, the causal components derived from…”
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Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses by Assinger, A, Wang, Y, Butler, L M, Hansson, G K, Yan, Z-Q, Söderberg-Nauclér, C, Ketelhuth, D F J

“…Low-density lipoproteins (LDL), occurring in vivo in both their native and oxidative form, modulate platelet function and thereby contribute to…”
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