Search Results - "Kestin, A S"

Effect of strenuous exercise on platelet activation state and reactivity by KESTIN, A. S, ELLIS, P. A, BARNARD, M. R, ERRICHETTI, A, ROSNER, B. A, MICHELSON, A. D

“…It has been hypothesized that platelets are activated, or made more activatible, by strenuous exercise and that these changes may play a role in the genesis of…”
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The Platelet Function Defect of Cardiopulmonary Bypass by Kestin, Anita S., Valeri, C. Robert, Khuri, Shukri F., Loscalzo, Joseph, Ellis, Patricia A., MacGregor, Hollace, Birjiniuk, Vladimir, Ouimet, Helene, Pasche, Boris, Nelson, Martha J., Benoit, Stephen E., Rodino, Louis J., Barnard, Marc R., Michelson, Alan D.

“…The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding…”
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Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood by Rajasekhar, D, Kestin, A S, Bednarek, F J, Ellis, P A, Barnard, M R, Michelson, A D

“…Previous studies have reported that the platelets of healthy term neonates have either diminished or normal reactivity compared to the platelets of adults. To…”
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Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro by Michelson, A D, MacGregor, H, Barnard, M R, Kestin, A S, Rohrer, M J, Valeri, C R

“…A hypothermia-induced hemorrhagic diathesis is associated with cardiopulmonary bypass, major surgery, and multiple trauma, but its pathophysiological basis is…”
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Downregulation of the Platelet Surface Glycoprotein Ib-IX Complex in Whole Blood Stimulated by Thrombin, Adenosine Diphosphate, or an In Vivo Wound by Michelson, Alan D., Ellis, Patricia A., Barnard, Marc R., Matic, Goran B., Viles, Andrew F., Kestin, Anita S.

“…In washed platelet systems, thrombin has been demonstrated to downregulate the platelet surface expression of glycoprotein (GP) lb and GPIX. In the present…”
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The Activation-Induced Decrease in the Platelet Surface Expression of the Glycoprotein Ib-IX Complex Is Reversible by Michelson, Alan D., Benoit, Stephen E., Kroll, Michael H., Li, Jian-Ming, Rohrer, Michael J., Kestin, Anita S., Barnard, Marc R.

“…Thrombin decreases the platelet surface expression of the glycoprotein (GP) Ib-IX complex. To determine whether this effect is reversible, flow cytometric…”
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Platelet activation results in a redistribution of glycoprotein IV (CD36) by MICHELSON, A. D, WENCEL-DRAKE, J. D, KESTIN, A. S, BARNARD, M. R

“…To investigate the possibility that thrombin and/or other platelet activators change the platelet surface expression of glycoprotein IV (GPIV, CD36), we used a…”
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Factor IXa-factor VIIIa-cell surface complex does not contribute to the basal activation of the coagulation mechanism in vivo by BAUER, K. A, MANNUCCI, P. M, GRINGERI, A, TRADATI, F, BARZEGAR, S, KASS, B. L, TEN CATE, H, KESTIN, A. S, BRETTLER, D. B, ROSENBERG, R. D

“…We have infused recombinant factor VIIa into patients with hereditary factor VII deficiency with marked reductions in plasma concentrations of factor IX…”
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A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen by Ward, C M, Kestin, A S, Newman, P J

“…Platelet retraction of a fibrin clot is mediated by the platelet fibrinogen receptor, alpha(IIb)beta(3). In certain forms of the inherited platelet disorder,…”
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High-level expression of antibody-plasminogen activator fusion proteins in hybridoma cells by Love, T W, Quertermous, T, Zavodny, P J, Runge, M S, Chou, C C, Mullins, D, Huang, P L, Schnee, J M, Kestin, A S, Savard, C E

“…We show that the mouse gamma 2b heavy chain or human beta-globin 3' untranslated region can greatly enhance protein expression in myeloma cells transfected by…”
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High-dose heparin suppresses platelet alpha granule secretion by Rohrer, Michael J., Kestin, Anita S., Ellis, Patricia A., Barnard, Marc R., Rodino, Louis, Breckwoldt, William L., Li, Jian-Ming, Michelson, Alan D.

“…Platelet degranulation has been implicated in the pathophysiology of acute arterial thrombosis, intimal hyperplasia, and atherogenesis. Most previous studies…”
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A Leu262Pro mutation in the integrin β3 subunit results in an αIIb-β3 complex that binds fibrin but not fibrinogen by WARD, C. M, KESTIN, A. S, NEWMAN, P. J

“…Abstract Platelet retraction of a fibrin clot is mediated by the platelet fibrinogen receptor, IIbβ3. In certain forms of the inherited platelet disorder,…”
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Platelet Aggregation Abnormalities after Cardiopulmonary Bypass by Ferraris, Victor A., Rodriguez, Evelio, Ferraris, Suellen P., Huang, Mark, Gupta, Atul, Bennett, James A., Andersen, Thomas T., Dunn, Harry, Fenton II, John W., Smith, J. Bryan

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High-dose heparin suppresses platelet alpha granule secretion. Discussion by ROHRER, M. J, KESTIN, A. S, ELLIS, P. A, BARNARD, M. R, RODINO, L, BRECKWOLDT, W. L, JIAN-MING LI, MICHELSON, A. D, SUMPIO, B, ROHRER, M

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The activation-induced decrease in the platelet surface expression of the glycoprotein Ib-IX complex is reversible by Michelson, AD, Benoit, SE, Kroll, MH, Li, JM, Rohrer, MJ, Kestin, AS, Barnard, MR

“…Thrombin decreases the platelet surface expression of the glycoprotein (GP) Ib-IX complex. To determine whether this effect is reversible, flow cytometric…”
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Downregulation of the platelet surface glycoprotein Ib-IX complex in whole blood stimulated by thrombin, adenosine diphosphate, or an in vivo wound [see comments] by Michelson, AD, Ellis, PA, Barnard, MR, Matic, GB, Viles, AF, Kestin, AS

“…In washed platelet systems, thrombin has been demonstrated to downregulate the platelet surface expression of glycoprotein (GP) Ib and GPIX. In the present…”
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Factor IXa-factor VIIIa-cell surface complex does not contribute to the basal activation of the coagulation mechanism in vivo by Bauer, KA, Mannucci, PM, Gringeri, A, Tradati, F, Barzegar, S, Kass, BL, ten Cate, H, Kestin, AS, Brettler, DB, Rosenberg, RD

“…We have infused recombinant factor VIIa into patients with hereditary factor VII deficiency with marked reductions in plasma concentrations of factor IX…”
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