Search Results - "Kesteven, Scott"

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number by Naqvi, Nawazish, Li, Ming, Calvert, John W., Tejada, Thor, Lambert, Jonathan P., Wu, Jianxin, Kesteven, Scott H., Holman, Sara R., Matsuda, Torahiro, Lovelock, Joshua D., Howard, Wesley W., Iismaa, Siiri E., Chan, Andrea Y., Crawford, Brian H., Wagner, Mary B., Martin, David I.K., Lefer, David J., Graham, Robert M., Husain, Ahsan

“…It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby causing binucleation and limiting regenerative repair…”
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High-Frequency Echocardiography　― Transformative Clinical and Research Applications in Humans, Mice, and Zebrafish by Wang, Louis W., Kesteven, Scott H., Huttner, Inken G., Feneley, Michael P., Fatkin, Diane

“…Echocardiography is an invaluable tool for characterizing cardiac structure and function in vivo. Technological advances in high-frequency ultrasound over the…”
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Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models by Wang, Louis W, Huttner, Inken G, Santiago, Celine F, Kesteven, Scott H, Yu, Ze-Yan, Feneley, Michael P, Fatkin, Diane

“…The zebrafish (Danio rerio) is an increasingly popular model organism in cardiovascular research. Major insights into cardiac developmental processes have been…”
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Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction by Thavapalachandran, Sujitha, Grieve, Stuart M, Hume, Robert D, Le, Thi Yen Loan, Raguram, Kalyan, Hudson, James E, Pouliopoulos, Jim, Figtree, Gemma A, Dye, Rafael P, Barry, Anthony M, Brown, Paula, Lu, Juntang, Coffey, Sean, Kesteven, Scott H, Mills, Richard J, Rashid, Fairooj N, Taran, Elena, Kovoor, Pramesh, Thomas, Liza, Denniss, Alan Robert, Kizana, Eddy, Asli, Naisana S, Xaymardan, Munira, Feneley, Michael P, Graham, Robert M, Harvey, Richard P, Chong, James J H

“…Therapies that target scar formation after myocardial infarction (MI) could prevent ensuing heart failure or death from ventricular arrhythmias. We have…”
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Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes by Nicks, Amy M., Kesteven, Scott H., Li, Ming, Wu, Jianxin, Chan, Andrea Y., Naqvi, Nawazish, Husain, Ahsan, Feneley, Michael P., Smith, Nicola J., Iismaa, Siiri E., Graham, Robert M.

“…Animal models of pressure overload are valuable for understanding hypertensive heart disease. We characterised a surgical model of pressure overload-induced…”
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The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy by Guo, Yang, Yu, Ze-Yan, Wu, Jianxin, Gong, Hutao, Kesteven, Scott, Iismaa, Siiri E, Chan, Andrea Y, Holman, Sara, Pinto, Silvia, Pironet, Andy, Cox, Charles D, Graham, Robert M, Vennekens, Rudi, Feneley, Michael P, Martinac, Boris

“…Pathological left ventricular hypertrophy (LVH) occurs in response to pressure overload and remains the single most important clinical predictor of cardiac…”
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Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice by Nikolova, Vesna, Leimena, Christiana, McMahon, Aisling C, Tan, Ju Chiat, Chandar, Suchitra, Jogia, Dilesh, Kesteven, Scott H, Michalicek, Jan, Otway, Robyn, Verheyen, Fons, Rainer, Stephen, Stewart, Colin L, Martin, David, Feneley, Michael P, Fatkin, Diane

“…Laminopathies are a group of disorders caused by mutations in the LMNA gene that encodes the nuclear lamina proteins, lamin A and lamin C; their…”
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RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility by Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C, Iismaa, Siiri E, Xiao, Xiao-Hui, Kesteven, Scott H, Reichelt, Melissa E, Mohl, Marion C, Smith, Nicola J, Fatkin, Diane, Allen, David, Head, Stewart I, Graham, Robert M, Feneley, Michael P

“…To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility. We reported previously that transgenic mice with…”
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Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload by Yu, Ze-Yan, Gong, Hutao, Wu, Jianxin, Dai, Yun, Kesteven, Scott H, Fatkin, Diane, Martinac, Boris, Graham, Robert M, Feneley, Michael P

“…Gq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although…”
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Effects of Mechanical Stress and Carvedilol in Lamin A/C–Deficient Dilated Cardiomyopathy by Chandar, Suchitra, Yeo, Li Sze, Leimena, Christiana, Tan, Ju-Chiat, Xiao, Xiao-Hui, Nikolova-Krstevski, Vesna, Yasuoka, Yoshinori, Gardiner-Garden, Margaret, Wu, Jianxin, Kesteven, Scott, Karlsdotter, Lina, Natarajan, Shweta, Carlton, Arthur, Rainer, Stephen, Feneley, Michael P, Fatkin, Diane

“…RATIONALE:Mutations in the LMNA gene, which encodes the nuclear lamina proteins lamin A and lamin C, are the most common cause of familial dilated…”
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Pressure Overload by Transverse Aortic Constriction Induces Maladaptive Hypertrophy in a Titin-Truncated Mouse Model by Harvey, Richard P., Gramlich, Michael, Gawaz, Meinrad, Aidery, Parwez, Wu, Jianxin, Kesteven, Scott, Zhou, Qifeng, Feneley, Michael P.

“…Mutations in the giant sarcomeric protein titin (TTN) are a major cause for inherited forms of dilated cardiomyopathy (DCM). We have previously developed a…”
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Functional evidence of reversible ischemic injury immediately after the sympathetic storm associated with experimental brain death by Ryan, Jonathon B, Hicks, Mark, Cropper, Jonathan R, Garlick, Sarah R, Kesteven, Scott H, Wilson, Michael K, Feneley, Michael P, Macdonald, Peter S

“…Acute brain death from increased intracranial pressure results in a transient increase in myocardial adenosine and lactate, which indicates that oxygen demand…”
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Cariporide (HOE-642) improves cardiac allograft preservation in a porcine model of orthotopic heart transplantation by RYAN, Jonathon B, HICKS, Mark, CROPPER, Jonathan R, GARLICK, Sarah R, KESTEVEN, Scott H, WILSON, Michael K, FENELEY, Michael P, MACDONALD, Peter S

“…Acute graft dysfunction caused by ischemia-reperfusion injury is recognized as a major source of morbidity and mortality following adult heart transplantation…”
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The preload recruitable stroke work relationship as a measure of left ventricular contractile dysfunction in porcine cardiac allografts by Ryan, Jonathon B., Hicks, Mark, Cropper, Jonathan R., Garlick, Sarah R., Kesteven, Scott H., Wilson, Michael K., Macdonald, Peter S., Feneley, Michael P.

“…Objective: Paradoxically, it has been reported that after 1.5–4 h of hypothermic ischaemic preservation there is complete recovery of contractile function in…”
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Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart by Milenkovic, Ivan, Santos Vieira, Helaine Graziele, Lucas, Morghan C, Ruiz-Orera, Jorge, Patone, Giannino, Kesteven, Scott, Wu, Jianxin, Feneley, Michael, Espadas, Guadalupe, Sabidó, Eduard, Hübner, Norbert, van Heesch, Sebastiaan, Völkers, Mirko, Novoa, Eva Maria

“…Abstract The existence of naturally occurring ribosome heterogeneity is now a well-acknowledged phenomenon. However, whether this heterogeneity leads to…”
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Endothelial nitric oxide synthase plays a protective role in endothelial cells and cardiomyocytes against myocardial infarction by Gentile, Carmine, Kesteven, Scott, Wu, Jianxin, Davies, Michael J., Bursill, Christina, Feneley, Michael, Figtree, Gemma

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Abstract 138: A Novel Cellular and Genetic Approach to Investigate the Cardioprotective Role Played by Endothelial Nitric Oxide Synthase in Myocardial Infarction by Gentile, Carmine, Kesteven, Scott, Wu, Jianxin, Bursill, Christina, Davies, Michael J, Figtree, Gemma

“…Abstract only The loss of regenerative properties in adult cardiomyocytes (CMs) is directly linked to their inability to proliferate. Following an extensive…”
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Piezo1 and TRPM4 work in tandem to initiate cardiac hypertrophic signalling in response to pressure overload by Yu, Ze-Yan, Gong, Hutao, Kesteven, Scott, Guo, Yang, Wu, Jianxin, Li, Jinyuan, Iismaa, Siiri, Kaidonis, Xenia, Graham, Robert M., Cox, Charles D., Feneley, Michael P., Martinac, Boris

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Calcineurin inhibition does not prevent left ventricular hypertrophy but does suppress its molecular markers in a rat model of low-renin, mild pressure overload by McMahon, Alsling C., Benson, Victoria L., Kesteven, Scott H., Feneley, Michael P.

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Sodium-hydrogen exchanger inhibition, pharmacologic ischemic preconditioning, or both for extended cardiac allograft preservation by RYAN, Jonathon B, HICKS, Mark, CROPPER, Jonathan R, GARLICK, Sarah R, KESTEVEN, Scott H, WILSON, Michael K, FENELEY, Michael P, MACDONALD, Peter S

“…The aim of this study was to determine the efficacy of cariporide (a sodium-hydrogen exchanger inhibitor), BMS180448 (a pharmacologic ischemic preconditioning…”
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