Search Results - "Kessler, PD"

Myoblast cell grafting into heart muscle: cellular biology and potential applications by Kessler, P D, Byrne, B J

“…This review surveys a wide range of cellular and molecular approaches to strengthening the injured or weakened heart, focusing on strategies to replace…”
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Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart by TOMA, Catalin, PITTENGER, Mark F, CAHILL, Kevin S, BYRNE, Barry J, KESSLER, Paul D

“…Cellular cardiomyoplasty has been proposed as an alternative strategy for augmenting the function of diseased myocardium. We investigated the potential of…”
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Immunogenicity and Smoking-Cessation Outcomes for a Novel Nicotine Immunotherapeutic by Hatsukami, DK, Jorenby, DE, Gonzales, D, Rigotti, NA, Glover, ED, Oncken, CA, Tashkin, DP, Reus, VI, Akhavain, RC, Fahim, REF, Kessler, PD, Niknian, M, Kalnik, MW, Rennard, SI

“…NicVAX, a nicotine vaccine (3′AmNic‐rEPA), has been clinically evaluated to determine whether higher antibody (Ab) concentrations are associated with higher…”
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Regional angiogenesis with Vascular Endothelial growth factor in peripheral arterial disease: A phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication by RAJAGOPALAN, Sanjay, MOHLER, Emile R, ANNEX, Brian H, LEDERMAN, Robert J, MENDELSOHN, Farrell O, SAUCEDO, Jorge F, GOLDMAN, Corey K, BLEBEA, John, MACKO, Jennifer, KESSLER, Paul D, RASMUSSEN, Henrik S

“…"Therapeutic angiogenesis" seeks to improve perfusion by the growth of new blood vessels. The Regional Angiogenesis with Vascular Endothelial growth factor…”
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Gene Delivery to Skeletal Muscle Results in Sustained Expression and Systemic Delivery of a Therapeutic Protein by Kessler, Paul D., Podsakoff, Gregory M., Chen, Xiaojuan, McQuiston, Susan A., Colosi, Peter C., Matelis, Laura A., Kurtzman, Gary J., Byrne, Barry J.

“…Somatic gene therapy has been proposed as a means to achieve systemic delivery of therapeutic proteins. However, there is limited evidence that current methods…”
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A Phase I Trial of TNFerade Biologic in Patients with Soft Tissue Sarcoma in the Extremities by MUNDT, Arno J, VIJAYAKUMAR, Srinivasan, KESSLER, Paul D, RASMUSSEN, Henrik S, WARSO, Michael, KUFE, Donald W, TAPAS DAS GUPTA, WEICHSELBAUM, Ralph R, NEMUNAITIS, John, SANDLER, Alan, SCHWARTZ, Herbert, HANNA, Nader, PEABODY, Terrence, SENZER, Neil, CHU, Karen, RASMUSSEN, Camilla S

“…Purpose: TNFerade is a second-generation replication-deficient adenovector carrying a transgene encoding human tumor necrosis factor α under control of a…”
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Inhibitors of the renin–angiotensin system and SARS-CoV-2 infection by Kessler, Thorsten, Schunkert, Heribert

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Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions by Harvey, Ben-Gary, Maroni, Jaman, O'Donoghue, Kelley A, Chu, Karen W, Muscat, Jolene C, Pippo, Allison L, Wright, Connie E, Hollmann, Charleen, Wisnivesky, Juan P, Kessler, Paul D, Rasmussen, Henrik S, Rosengart, Todd K, Crystal, Ronald G

“…To help define the safety profile of the use of adenovirus (Ad) gene transfer vectors in humans, this report summarizes our experience since April 1993 of the…”
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Correction of the Enzymatic and Functional Deficits in a Model of Pompe Disease Using Adeno-associated Virus Vectors by Fraites, Thomas J., Schleissing, Mary R., Shanely, R.Andrew, Walter, Glenn A., Cloutier, Denise A., Zolotukhin, Irene, Pauly, Daniel F., Raben, Nina, Plotz, Paul H., Powers, Scott K., Kessler, Paul D., Byrne, Barry J.

“…Pompe disease is a lysosomal storage disease caused by the absence of acid α-1,4 glucosidase (GAA). The pathophysiology of Pompe disease includes generalized…”
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Sudden cardiac death in heart failure : the role of abnormal repolarization by TOMASELLI, G. F, BEUCKELMAN, D. J, CALKINS, H. G, BERGER, R. D, KESSLER, P. D, LAWRENCE, J. H, KASS, D, FELDMAN, A. M, MARBAN, E

“…Congestive heart failure is a common, highly lethal cardiovascular disorder claiming over 200,000 lives a year in the United States alone. Some 50% of the…”
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Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions by Crystal, Ronald G, Harvey, Ben-Gary, Wisnivesky, Juan P, O'Donoghue, Kelley A, Chu, Karen W, Maroni, Jaman, Muscat, Jolene C, Pippo, Allison L, Wright, Connie E, Kaner, Robert J, Leopold, Philip L, Kessler, Paul D, Rasmussen, Henrik S, Rosengart, Todd K, Hollmann, Charleen

“…In this study we analyze the adverse events and abnormal laboratory parameters following local administration of low (<10(9) particle units) and intermediate…”
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Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model by Wang, Kai, Kessler, Paul D, Zhou, Zhongmin, Penn, Marc S, Forudi, Farhad, Zhou, Xiaorong, Tarakji, Khaldoun, Kibbe, Melina, Kovesdi, Imre, Brough, Douglas E, Topol, Eric J, Lincoff, A.Michael

“…In this study the effect of local adenoviral-mediated delivery of inducible nitric oxide synthase on restenosis was evaluated in a porcine coronary stented…”
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Intercellular transfer of the virally derived precursor form of acid alpha-glucosidase corrects the enzyme deficiency in inherited cardioskeletal myopathy Pompe disease by Pauly, D F, Fraites, T J, Toma, C, Bayes, H S, Huie, M L, Hirschhorn, R, Plotz, P H, Raben, N, Kessler, P D, Byrne, B J

“…Pompe disease is a lethal cardioskeletal myopathy in infants and results from genetic deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA). Genetic…”
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Increased revascularization efficacy after administration of an adenovirus encoding VEGF by Perrin, L A, June, J E, Rosebury, W, Robertson, A, Kovesdi, I, Bruder, J T, Kessler, P D, Keiser, J A, Gordon, D

“…Adenovirus-mediated VEGF gene delivery is being evaluated in clinical trials as a treatment for patients with vascular diseases that stem from ischemia, such…”
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Prevention and reversal of nitrate tolerance in patients with congestive heart failure by Packer, M, Lee, W H, Kessler, P D, Gottlieb, S S, Medina, N, Yushak, M

“…To evaluate possible mechanisms underlying the development of nitrate tolerance, we treated 35 patients who had severe chronic heart failure with a prolonged…”
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Arterial delivery of genetically labelled skeletal myoblasts to the murine heart: long-term survival and phenotypic modification of implanted myoblasts by Robinson, S W, Cho, P W, Levitsky, H I, Olson, J L, Hruban, R H, Acker, M A, Kessler, P D

“…The ability to replace damaged myocardial tissue with new striated muscle would constitute a major advance in the treatment of diseases that irreversibly…”
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Complete correction of acid α-glucosidase deficiency in pompe disease fibroblasts in vitro, and lysosomally targeted expression in neonatal rat cardiac and skeletal muscle by PAULY, D. F, JOHNS, D. C, MATELIS, L. A, LAWRENCE, J. H, BYRNE, B. J, KESSLER, P. D

“…The enzyme acid alpha-glucosidase catalyzes the breakdown of lysosomal glycogen. Absence of this enzyme results in infantile Pompe disease, characterized by…”
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Nucleotide sequences of avian cardiac and brain SR/ER Ca2+-ATPases and functional comparisons with fast twitch Ca2+-ATPase: calcium affinities and inhibitor effects by CAMPBELL, A. M, KESSLER, P. D, SAGARA, Y, INESI, G, FAMBROUGH, D. M

“…Two similar forms of the cardiac/slow Ca2+-ATPase (SERCA2a and SERCA2b), differing in sodium dodecyl sulfate-polyacrylamide gel electrophoresis mobility, are…”
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The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca2+-ATPases are on opposite sides of the membrane by MALCOLM CAMPBELL, A, KESSLER, P. D, FAMBROUGH, D. M

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Cell-specific promoter in adenovirus vector for transgenic expression of SERCA1 ATPase in cardiac myocytes by Inesi, G, Lewis, D, Sumbilla, C, Nandi, A, Strock, C, Huff, K W, Rogers, T B, Johns, D C, Kessler, P D, Ordahl, C P

“…Adenovirus-mediated transfer of cDNA encoding the chicken skeletal muscle sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1) yielded selective expression in…”
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