Search Results - "Keskeny, Csilla"
-
1
4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay
Published in Cell reports (Cambridge) (13-10-2020)“…Current models of mRNA turnover indicate that cytoplasmic degradation is coupled with translation. However, our understanding of the molecular events that…”
Get full text
Journal Article -
2
A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex
Published in Genes & development (01-02-2019)“…The multisubunit CCR4-NOT mRNA deadenylase complex plays important roles in the posttranscriptional regulation of gene expression. The NOT4 E3 ubiquitin ligase…”
Get full text
Journal Article -
3
Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets
Published in RNA (Cambridge) (01-03-2018)“…Bag-of-marbles (Bam) promotes germline stem cell (GSC) differentiation by repressing the expression of mRNAs encoding stem cell maintenance factors. Bam…”
Get full text
Journal Article -
4
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Published in Nature communications (16-11-2020)“…MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular…”
Get full text
Journal Article -
5
Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis
Published in Scientific reports (13-06-2016)“…Loss of function of the tumour suppressor p53 observed frequently in human cancers challenges the drug-induced apoptotic elimination of cancer cells from the…”
Get full text
Journal Article