Search Results - "Kesavan, C"

AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome by Campbell, Aoife, Morris, Gareth, Sanfeliu, Albert, Augusto, Joana, Langa, Elena, Kesavan, Jaideep C., Nguyen, Ngoc T., Conroy, Ronan M., Worm, Jesper, Kielpinski, Lukasz, Jensen, Mads Aaboe, Miller, Meghan T., Kremer, Thomas, Reschke, Cristina R., Henshall, David C.

“…Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia, cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations…”
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Identification of novel small molecules that bind to the loop2 region of sclerostin - an in silico computational analysis by Muthusamy, K, Mohan, S, Nagamani, S, Kesavan, C

“…The goal of this study was to identify small molecular weight compounds that bind to sclerostin using in-silico methods because of the established importance…”
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APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation by Mertens, Jerome, Stüber, Kathrin, Wunderlich, Patrick, Ladewig, Julia, Kesavan, Jaideep C., Vandenberghe, Rik, Vandenbulcke, Mathieu, van Damme, Philip, Walter, Jochen, Brüstle, Oliver, Koch, Philipp

“…Increasing evidence suggests that elevated Aβ42 fractions in the brain cause Alzheimer’s disease (AD). Although γ-secretase modulators (GSMs), including a set…”
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Systemic administration of an antagomir designed to inhibit miR-92, a regulator of angiogenesis, failed to modulate skeletal anabolic response to mechanical loading by Sengul, A, Santisuk, R, Xing, W, Kesavan, C

“…The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of…”
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Opposing effects of Sca-1+ cell-based systemic FGF2 gene transfer strategy on lumbar versus caudal vertebrae in the mouse by Lau, K-H W, Chen, S-T, Wang, X, Mohan, S, Wergedal, J E, Kesavan, C, Srivastava, A K, Gridley, D S, Hall, S L

“…Our previous work showed that a Sca-1 + cell-based FGF2 therapy was capable of promoting robust increases in trabecular bone formation and connectivity on the…”
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Conditional Knockout of the MicroRNA 17-92 Cluster in Type-I Collagen-Expressing Cells Decreases Alveolar Bone Size and Incisor Tooth Mechanical Properties by Ibrahim, M, Mohan, S, Xing, M J, Kesavan, C

“…To test the role of the miR17-92 (miR) cluster in dental bones, we evaluated the incisor tooth phenotype by micro-CT in 5- and 12-week-old conditional knockout…”
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Bone response to loading in mice with targeted disruption of the cartilage oligomeric matrix protein gene by Sengul, A, Mohan, S, Kesavan, C

“…Exercise induced bone response although established, little is known about the molecular components that mediate bone response to mechanical loading (ML). In…”
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SU‐E‐T‐522: Evaluation of EDW and Sliding Window IMRT in the Presence of Organ Motion with Gating by Das, KJ Maria, Yoganathan, SA, Kumar, SK Senthil, Kesavan, C, Vikram, R, Kumar, S

“…Purpose: To investigate the interplay effect of intrafractional motion when using Enhanced Dynamic Wedge (EDW) and Intensity Modulated Radiotherapy (IMRT) with…”
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MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control by Heiland, Mona, Connolly, Niamh M C, Mamad, Omar, Nguyen, Ngoc T, Kesavan, Jaideep C, Langa, Elena, Fanning, Kevin, Sanfeliu, Albert, Yan, Yan, Su, Junyi, Venø, Morten T, Costard, Lara S, Neubert, Valentin, Engel, Tobias, Hill, Thomas D M, Freiman, Thomas M, Mahesh, Arun, Tiwari, Vijay K, Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Morris, Gareth, Henshall, David C

“…There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium channel blockers are effective for seizure control in common forms of…”
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Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species by Devasagayam, T.P.A., Kamat, J.P., Mohan, Hari, Kesavan, P.C.

“…Caffeine (1,3,7-trimethyl xanthine), an ingredient of coffee, has been investigated for its potential antioxidant activity against oxidative damage to rat…”
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Radiation protection policies and practice rest on a thin sheet of ice called linear, no-threshold hypothesis by Kesavan, P

“…[...]Taylor [28] in his 1980 Sievert Lecture stated that "some non-scientific influences prevail over scientific facts on radiation protection standards."…”
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Leaf-eating caterpillar (Opisina arenosella)-induced yield loss in coconut palm by Mohan, Chandrika, Radhakrishnan Nair, C.P., Nampoothiri, C. Kesavan, Rajan, P.

“…Coconut is one of the major crops of commercial importance among the palms. The leaf-eating caterpillar Opisina arenosella Walker is the most important…”
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Strategies and models for agricultural sustainability in developing Asian countries by Kesavan, P.C, Swaminathan, M.S

“…The green revolution of the 1960s and 1970s which resulted in dramatic yield increases in the developing Asian countries is now showing signs of fatigue in…”
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2014 International Year of Family Farming: a boost to evergreen revolution by Kesavan, P. C., Swaminathan, M. S.

“…The evergreen revolution aims at achieving productivity in perpetuity without accompanying ecological and social harm. The smallholder family farms with…”
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Mechanism of protection against radiation-induced DNA damage in plasmid pBR322 by caffeine by Kumar, S. S., Devasagayam, T. P. A., Jayashree, B., Kesavan, P. C.

“…Purpose : Caffeine (1,3,7-trimethyl xanthine), a dietary component, has been shown to have widely varying effects on DNA damage induced by UV and ionizing…”
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Differential modification by caffeine of oxygen-dependent and independent effects of γ-irradiation on rat liver mitochondria by KAMAT, J. P, BOLOOR, K. K, DEVASAGAYAM, T. P. A, JAYASHREE, B, KESAVAN, P. C

“…Purpose : Following the demonstration that caffeine effectively competes with oxygen for electrons and also scavenges hydroxyl radicals and singlet oxygen, the…”
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Differential microRNA editing may drive target pathway switching in human temporal lobe epilepsy by Lau, Kelvin E How, Nguyen, Ngoc T, Kesavan, Jaideep C, Langa, Elena, Fanning, Kevin, Brennan, Gary P, Sanz-Rodriguez, Amaya, Villegas-Salmerón, Javier, Yan, Yan, Venø, Morten T, Mills, James D, Rosenow, Felix, Bauer, Sebastian, Kjems, Jørgen, Henshall, David C

“…Abstract MicroRNAs have emerged as important regulators of the gene expression landscape in temporal lobe epilepsy. The mechanisms that control microRNA levels…”
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Green to evergreen revolution: ecological and evolutionary perspectives in pest management by Kesavan, P. C., Malarvannan, S.

“…The experience and lessons learnt from the green revolution make it imperative that sustainable productivity requires strict adherence to agricultural…”
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Protective effects of vitamins C and E against gamma-ray-induced chromosomal damage in mouse by Sarma, L, Kesavan, P C

“…The effects of vitamins C and E on bone marrow chromosomes of the mouse exposed to 1 Gy of whole-body gamma-irradiation were studied. These vitamins, dissolved…”
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Genetic Monitoring of the Human Population from High-Level Natural Radiation Areas of Kerala on the Southwest Coast of India. II. Incidence of Numerical and Structural Chromosomal Aberrations in the Lymphocytes of Newborns by Cheriyan, V. D., Kurien, C. J., Das, Birajalaxmi, Ramachandran, E. N., Karuppasamy, C. V., Thampi, M. V., George, K. P., Kesavan, P. C., Koya, P. K. M., Chauhan, P. S.

“…Cytogenetic studies using cord blood samples from newborns from high-level natural radiation areas of the Kerala coast in Southwest India have been in progress…”
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