Search Results - "Kervio, Eric"

The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA by Kervio, Eric, Sosson, Marilyne, Richert, Clemens

“…The template-directed incorporation of nucleotides at the terminus of a growing primer is the basis of the transmission of genetic information. Nature uses…”
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Ribonucleotides and RNA Promote Peptide Chain Growth by Griesser, Helmut, Tremmel, Peter, Kervio, Eric, Pfeffer, Camilla, Steiner, Ulrich E., Richert, Clemens

“…All known forms of life use RNA‐mediated polypeptide synthesis to produce the proteins encoded in their genes. Because the principal parts of the translational…”
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Templating efficiency of naked DNA by Kervio, Eric, Hochgesand, Annette, Steiner, Ulrich E., Richert, Clemens, Piccirilli, Joseph A

“…Template-directed synthesis of complementary strands is pivotal for life. Nature employs polymerases for this reaction, leaving the ability of DNA itself to…”
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The Effect of Pooling on the Detection of the Nucleocapsid Protein of SARS-CoV-2 with Rapid Antigen Tests by Berking, Tim, Lorenz, Sabrina G, Ulrich, Alexander B, Greiner, Joachim, Kervio, Eric, Bremer, Jennifer, Wege, Christina, Kleinow, Tatjana, Richert, Clemens

“…The COVID-19 pandemic puts significant stress on the viral testing capabilities of many countries. Rapid point-of-care (PoC) antigen tests are valuable tools…”
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High Fidelity Enzyme‐Free Primer Extension with an Ethynylpyridone Thymidine Analog by Han, Jianyang, Kervio, Eric, Richert, Clemens

“…High fidelity base pairing is important for the transmission of genetic information. Weak base pairs can lower fidelity, complicating sequencing, amplification…”
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Prolinyl Nucleotides Drive Enzyme-Free Genetic Copying of RNA by Welsch, Franziska, Kervio, Eric, Tremmel, Peter, Richert, Clemens

“…Proline is one of the proteinogenic amino acids. It is found in all kingdoms of life. It also has remarkable activity as an organocatalyst and is of structural…”
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Inside Back Cover: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. Int. Ed. 41/2023) by Welsch, Franziska, Kervio, Eric, Tremmel, Peter, Richert, Clemens

“…A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides,…”
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Amino Acid‐Specific, Ribonucleotide‐Promoted Peptide Formation in the Absence of Enzymes by Griesser, Helmut, Bechthold, Maren, Tremmel, Peter, Kervio, Eric, Richert, Clemens

“…Nucleic acids and polypeptides are at the heart of life. It is interesting to ask whether the monomers of these biopolymers possess intrinsic reactivity that…”
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Enzyme‐Free Copying of 12 Bases of RNA with Dinucleotides by Leveau, Gabrielle, Pfeffer, Daniel, Altaner, Bernhard, Kervio, Eric, Welsch, Franziska, Gerland, Ulrich, Richert, Clemens

“…The synthesis of complementary strands is the reaction underlying the replication of genetic information. It is likely that the earliest self‐replicating…”
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Inside Cover: Enzyme‐Free Copying of 12 Bases of RNA with Dinucleotides (Angew. Chem. Int. Ed. 29/2022) by Leveau, Gabrielle, Pfeffer, Daniel, Altaner, Bernhard, Kervio, Eric, Welsch, Franziska, Gerland, Ulrich, Richert, Clemens

“…Dinucleotides copy RNA in the absence of enzymes or ribozymes. Genetic copying, producing the complementary strand to a template, drives replication…”
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Innenrücktitelbild: Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA (Angew. Chem. 41/2023) by Welsch, Franziska, Kervio, Eric, Tremmel, Peter, Richert, Clemens

“…A new synergy between fundamental classes of biomolecules is reported by Clemens Richert et al. in their Research Article (e202307591). Prolinyl nucleotides,…”
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Prolinyl Nucleotides Drive Enzyme‐Free Genetic Copying of RNA by Welsch, Franziska, Kervio, Eric, Tremmel, Peter, Richert, Clemens

“…Proline is one of the proteinogenic amino acids. It is found in all kingdoms of life. It also has remarkable activity as an organocatalyst and is of structural…”
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The strength of the template effect attracting nucleotides to naked DNA by Kervio, Eric, Claasen, Birgit, Steiner, Ulrich E, Richert, Clemens

“…The transmission of genetic information relies on Watson-Crick base pairing between nucleoside phosphates and template bases in template-primer complexes…”
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Innentitelbild: Enzyme‐Free Copying of 12 Bases of RNA with Dinucleotides (Angew. Chem. 29/2022) by Leveau, Gabrielle, Pfeffer, Daniel, Altaner, Bernhard, Kervio, Eric, Welsch, Franziska, Gerland, Ulrich, Richert, Clemens

“…Dinukleotide kopieren RNA in Abwesenheit von Enzymen oder Ribozymen. Das genetische Kopieren, das den komplementären Strang zu einer Vorlage erzeugt, treibt…”
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Enzyme‐Free Copying of 12 Bases of RNA with Dinucleotides by Leveau, Gabrielle, Pfeffer, Daniel, Altaner, Bernhard, Kervio, Eric, Welsch, Franziska, Gerland, Ulrich, Richert, Clemens

“…The synthesis of complementary strands is the reaction underlying the replication of genetic information. It is likely that the earliest self‐replicating…”
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Cascade of Reduced Speed and Accuracy after Errors in Enzyme-Free Copying of Nucleic Acid Sequences by Leu, Kevin, Kervio, Eric, Obermayer, Benedikt, Turk-MacLeod, Rebecca M, Yuan, Caterina, Luevano, Jesus-Mario, Chen, Eric, Gerland, Ulrich, Richert, Clemens, Chen, Irene A

“…Nonenzymatic, template-directed synthesis of nucleic acids is a paradigm for self-replicating systems. The evolutionary dynamics of such systems depend on…”
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Chemical Primer Extension in Seconds by Röthlingshöfer, Manuel, Kervio, Eric, Lommel, Tanja, Plutowski, Ulrich, Hochgesand, Annette, Richert, Clemens

“…Rapid extention: Catalysis by pyridine accelerates template‐directed chemical primer extension to t1/2<1 min for all four nucleotides (A/C/G/T). For C and G,…”
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Amino Acid‐Specific, Ribonucleotide‐Promoted Peptide Formation in the Absence of Enzymes by Griesser, Helmut, Bechthold, Maren, Tremmel, Peter, Kervio, Eric, Richert, Clemens

“…Nucleic acids and polypeptides are at the heart of life. It is interesting to ask whether the monomers of these biopolymers possess intrinsic reactivity that…”
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Chemical Primer Extension: Efficiently Determining Single Nucleotides in DNA by Hagenbuch, Patrizia, Kervio, Eric, Hochgesand, Annette, Plutowski, Ulrich, Richert, Clemens

“…Rapid replication: Non‐enzymatic primer extension has previously been studied in the context of prebiotic chemistry, but not for practical applications…”
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Ribonucleotides and RNA Promote Peptide Chain Growth by Griesser, Helmut, Tremmel, Peter, Kervio, Eric, Pfeffer, Camilla, Steiner, Ulrich E., Richert, Clemens

“…All known forms of life use RNA‐mediated polypeptide synthesis to produce the proteins encoded in their genes. Because the principal parts of the translational…”
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