Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation

Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation

Platelets were shown to be relevant for liver regeneration. In particular, platelet-stored serotonin (5-HT) proved to be a pro-regenerative factor in this process. The present study aimed to investigate the perioperative course of 5-HT and evaluate associations with patient and graft outcomes after...

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Bibliographic Details
Published in:Journal of clinical medicine Vol. 13; no. 9; p. 2640
Main Authors: Zott, Tobias, Pereyra, David, Kersten, Isabelle, Ortner, Max, Hüpper, Maria Noelle, Starlinger, Patrick, Berlakovich, Gabriela A, Silberhumer, Gerd R
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-05-2024
Subjects:
Blood platelets
Liver
Liver cancer
Liver transplants
Mortality
Patients
Plasma
Receptors
Serotonin
Transplantation
Austria
Romania
liver regeneration
serotonin
liver transplantation
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Summary:Platelets were shown to be relevant for liver regeneration. In particular, platelet-stored serotonin (5-HT) proved to be a pro-regenerative factor in this process. The present study aimed to investigate the perioperative course of 5-HT and evaluate associations with patient and graft outcomes after othotopic liver transplantation (OLT). 5-HT was quantified in plasma and serum of 44 OLT recipients perioperatively, and in their respective donors. Olthoff's criteria for early allograft dysfunction (EAD) were used to evaluate postoperative outcomes. Patients with higher donor intra-platelet 5-HT per platelet (IP 5-HT PP) values had significantly lower postoperative transaminases (ASAT POD1: = 0.006, ASAT POD5: = 0.006, ASAT POD10: = 0.02, ALAT POD1: = 0.034, ALAT POD5: = 0.017, ALAT POD10: = 0.04). No significant differences were seen between postoperative 5-HT values and the occurrence of EAD. A tendency was measured that donor IP 5-HT PP is lower in donor-recipient pairs that developed EAD ( = 0.07). Donor IP 5-HT PP might be linked to the postoperative development of EAD after OLT, as higher donor levels are correlated with a more favorable postoperative course of transaminases. Further studies with larger cohorts are needed to validate these findings.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13092640