Search Results - "Kershaw, Yvonne"

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA by Pooley, John R, Rivers, Caroline A, Kilcooley, Michael T, Paul, Susana N, Cavga, Ayse Derya, Kershaw, Yvonne M, Muratcioglu, Serena, Gursoy, Attila, Keskin, Ozlem, Lightman, Stafford L

“…Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation…”
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Circadian regulation of hippocampal function is disrupted with corticosteroid treatment by Birnie, Matthew T, Claydon, Matthew D B, Troy, Oliver, Flynn, Benjamin P, Yoshimura, Mitsuhiro, Kershaw, Yvonne M, Zhao, Zidong, Demski-Allen, Rebecca C R, Barker, Gareth R I, Warburton, E Clea, Bortolotto, Zuner A, Lightman, Stafford L, Conway-Campbell, Becky L

“…Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of circadian biological systems is adrenal glucocorticoid…”
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Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver by Flynn, Benjamin P, Birnie, Matthew T, Kershaw, Yvonne M, Pauza, Audrys G, Kim, Sohyoung, Baek, Songjoon, Rogers, Mark F, Paterson, Alex R, Stavreva, Diana A, Murphy, David, Hager, Gordon L, Lightman, Stafford L, Conway-Campbell, Becky L

“…Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we…”
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The origin of glucocorticoid hormone oscillations by Walker, Jamie J, Spiga, Francesca, Waite, Eleanor, Zhao, Zidong, Kershaw, Yvonne, Terry, John R, Lightman, Stafford L

“…Oscillating levels of adrenal glucocorticoid hormones are essential for optimal gene expression, and for maintaining physiological and behavioural…”
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ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion by Spiga, Francesca, Waite, Eleanor J, Liu, Ying, Kershaw, Yvonne M, Aguilera, Greti, Lightman, Stafford L

“…Pulsatile pattern of ACTH activation of the adrenal cortex is critical for corticosterone secretion and induces episodic transcription of proteins important…”
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Time of day influences stress hormone response to ketamine by Birnie, Matthew T., Eapen, Alen V., Kershaw, Yvonne M., Lodge, David, Collingridge, Graham L., Conway‐Campbell, Becky L., Lightman, Stafford L.

“…Over 50% of depressed patients show hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis. Conventional therapy takes weeks to months to improve…”
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Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo by George, Charlotte L., Birnie, Matthew T., Flynn, Benjamin P., Kershaw, Yvonne M., Lightman, Stafford L., Conway-Campbell, Becky L.

“…In this paper we report differential decoding of the ultradian corticosterone signal by glucocorticoid target tissues. Pulsatile corticosterone replacement in…”
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Ultradian corticosterone secretion is maintained in the absence of circadian cues by Waite, Eleanor J., McKenna, Mervyn, Kershaw, Yvonne, Walker, Jamie J., Cho, Kwangwook, Piggins, Hugh D., Lightman, Stafford L.

“…Plasma levels of corticosterone exhibit both circadian and ultradian rhythms. The circadian component of these rhythms is regulated by the suprachiasmatic…”
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Genome-Wide Identification of Basic Helix–Loop–Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus by Pooley, John R., Flynn, Ben P., Grøntved, Lars, Baek, Songjoon, Guertin, Michael J., Kershaw, Yvonne M., Birnie, Matthew T., Pellatt, Annie, Rivers, Caroline A., Schiltz, R. Louis, Hager, Gordon L., Lightman, Stafford L., Conway-Campbell, Becky L.

“…Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type…”
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Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression by Yoshimura, Mitsuhiro, Flynn, Benjamin P., Kershaw, Yvonne M., Zhao, Zidong, Ueta, Yoichi, Lightman, Stafford L., Conway-Campbell, Becky L.

“…Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered when circulating glucocorticoid rhythms are dissociated from lighting…”
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Adaptive Changes in Basal and Stress-Induced HPA Activity in Lactating and Post-Lactating Female Rats by Windle, Richard J, Wood, Susan A, Kershaw, Yvonne M, Lightman, Stafford L, Ingram, Colin D

“…Lactation represents a period of marked adaptation of the hypothalamo–pituitary–adrenal HPA axis. We characterized basal and stress-induced HPA activity during…”
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Oxytocin Attenuates Stress-Induced c-fos mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo-Pituitary-Adrenal Activity by Windle, Richard J, Kershaw, Yvonne M, Shanks, Nola, Wood, Susan A, Lightman, Stafford L, Ingram, Colin D

“…We reported previously that the neuropeptide oxytocin attenuates stress-induced hypothalamo-pituitary-adrenal (HPA) activity and anxiety behavior. This study…”
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis Circadian Rhythm by Endocannabinoids Is Sexually Diergic by Atkinson, Helen C, Leggett, James D, Wood, Susan A, Castrique, Emma S, Kershaw, Yvonne M, Lightman, Stafford L

“…We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB1) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA)…”
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Gonadal Steroid Modulation of Stress-Induced Hypothalamo-Pituitary-Adrenal Activity and Anxiety Behavior: Role of Central Oxytocin by Windle, Richard J, Gamble, Lisa E, Kershaw, Yvonne M, Wood, Susan A, Lightman, Stafford L, Ingram, Colin D

“…Intracerebroventricular administration of oxytocin reduces anxiety behavior and hypothalamo-pituitary-adrenal (HPA) responses to stress in female rats. Similar…”
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Reversal of the hypothalamo-pituitary–adrenal response to oestrogens around puberty by Evuarherhe, Obaro, Leggett, James, Waite, Eleanor, Kershaw, Yvonne, Lightman, Stafford

“…The neuroendocrine gender dimorphism that begins during perinatal development is completed during puberty. We have previously described how the perinatal…”
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Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor by Atkinson, Helen C, Wood, Susan A, Castrique, Emma S, Kershaw, Yvonne M, Wiles, Crispin C R, Lightman, Stafford L

“…The aim of this study was to investigate fast corticosteroid feedback of the hypothalamic-pituitary-adrenal (HPA) axis under basal conditions, in particular…”
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Reduced stress responsiveness in pregnancy: Relationship with pattern of forebrain c- fos mRNA expression by Windle, Richard J, Wood, Susan A, Kershaw, Yvonne M, Lightman, Stafford L, Ingram, Colin D

“…Abstract Stress-induced activation of the hypothalamo-pituitary-adrenal (HPA) axis is known to be attenuated during late pregnancy and throughout lactation. To…”
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ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion by Spiga, Francesca, Waite, Eleanor J, Liu, Ying, Kershaw, Yvonne M, Aguilera, Greti, Lightman, Stafford L

“…This article appears in Endocrinology, published February 8, 2011, 10.1210/en.2010-1209…”
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Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding by Spiga, Francesca, Knight, David M, Droste, Susanne K, Conway-Campbell, Becky, Kershaw, Yvonne, MacSweeney, Cliona P, Thomson, Fiona J, Craighead, Mark, Peeters, Bernard WMM, Lightman, Stafford L

“…The effects of RU486 and S-P, a more selective glucocorticoid receptor antagonist from Schering-Plough, were investigated on glucocorticoid receptor nuclear…”
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Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery by Gibbison, Ben, Spiga, Francesca, Walker, Jamie J, Russell, Georgina M, Stevenson, Kirsty, Kershaw, Yvonne, Zhao, Zidong, Henley, David, Angelini, Gianni D, Lightman, Stafford L

“…OBJECTIVES:To characterize the dynamics of the pituitary-adrenal interaction during the course of coronary artery bypass grafting both on and off pump. Since…”
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